Publications by authors named "Yin-Fei Feng"
J Chem Inf Model
May 2024
Article Synopsis
- - Developing new drugs is expensive and risky, and understanding drug-protein interactions is crucial for effective treatment, a task being revolutionized by advances in deep learning (DL).
- - Two main challenges in this area are preventing gradient disappearance while capturing detailed local characteristics and understanding the overall interactions between drugs and proteins, both of which are essential for drug development.
- - The proposed DL network, MolLoG, features two key components—a local feature encoder to extract detailed characteristics and a global interactive learning module to combine these features effectively, outperforming existing models in predicting drug-target interactions across multiple datasets.
