Publications by Yin-Chu Zhu

Publications by authors named "Yin-Chu Zhu"

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High expression of the classical swine fever virus (CSFV) envelope protein E2 by a single amino acid mutation and its embedded in the pseudorabies virus (PRV) vector for immunization.

Yang-Yang Sun Ke-Shu Liu Tao Yun Zheng Ni Yin-Chu Zhu

Virus Res

July 2023

Article Synopsis

* Researchers have developed recombinant pseudorabies virus (PRV) that can express a full-length E2 protein, which is crucial for creating effective vaccines.
* The study shows that a modified full-length E2 protein can stimulate stronger immune responses in mice and rabbits, indicating potential for a new bivalent vaccine that protects against both PR and CSF.

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Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV.

Yang-Yang Sun Ke-Shu Liu Cun Zhang Zheng Ni Yin-Chu Zhu

Antiviral Res

March 2023

Pseudorabies (PR) and classical swine fever (CSF) are economically important infectious diseases of pigs. Most pig farms in China are immunized against these two diseases. Here, we describe a stabilized E2 protein as an immunogen inserted into the PRV genome as a bivalent live virus-vectored vaccine.

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