Publications by authors named "Yin Zheng"

Background Hypertrophic scarring is an abnormal condition involving excessive fibroblast activation, aberrant extracellular matrix deposition, and persistent inflammation. Current treatments have limited efficacy and potential adverse effects, necessitating the development of new approaches. Purpose In this study, we investigated the effects of artesunate (ART) on hypertrophic scar (HS) formation and explored the underlying cellular and molecular mechanisms.

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Subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells has demonstrated therapeutic potential in macular degeneration. However, its efficiency is limited in wet age-related macular degeneration (wet AMD) due to choroidal neovascularization (CNV). To investigate the feasibility of hESC-RPE cell transplantation, we employed a surgical approach to induce retinal detachment, which allowed the removal of CNV lesions.

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Introduction: Policy reforms in drug regulation and reimbursement have encouraged drug research and development in China. However, there is a lack of insights on industry trends for dermatology research. We aim to describe trends and features of clinical trials for dermatology drugs in China, understand recent achievements, and forecast development trends.

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The subventricular zone (SVZ) is a region surrounding the lateral ventricles that contains neural stem cells and neural progenitor cells, which can proliferate and differentiate into various neural and glial cells. SVZ cells play important roles in neurological diseases like neurodegeneration, neural injury, and glioblastoma multiforme. Investigating the anatomy, structure, composition, physiology, disease associations, and related mechanisms of SVZ is significant for neural stem cell therapy and treatment/prevention of neurological disorders.

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This study evaluates the effects of hydroxytyrosol (HT), a component of olive oil, on mammographic breast density reduction. We explored effects of HT on Wnt -catenin and other pathways involved in cancer stem cell renewal, DNA repair, cell proliferation, and differentiation. Twenty-five milligrams per day oral dose of HT was given for 12 months in pre- and postmenopausal women at increased risk of breast cancer.

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This retrospective study evaluated the efficacy of large language models (LLMs) in improving the accuracy of Chinese ultrasound reports. Data from three hospitals (January-April 2024) including 400 reports with 243 errors across six categories were analyzed. Three GPT versions and Claude 3.

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Background: Adjusting thickening agent proportions in nanoemulsion gel (NG) balances its transdermal and topical delivery properties, making it more effective for dermatophytosis treatment.

Methods: Carbomer 940 and α-pinene were used as model thickening agent and antifungal, respectively. A series of α-pinene NGs (αNG1, αNG2, αNG3) containing 0.

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Nonalcoholic fatty liver disease (NAFLD) is a metabolic liver disorder with severe complications. Mitochondrial dysfunction due to over-opening of the mitochondrial permeability transition pore (mPTP) in liver cells plays a central role in the development and progression of NAFLD. Restoring mitochondrial function is a promising strategy for NAFLD therapy.

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A strategically designed ternary nanohybrid (TNS-PDA/CNT), consisting of titanate nanosheet (TNS) and polydopamine-modified multiwalled carbon nanotube (PDA/CNT composite), was synthesized by the facile hydrothermal method and wet impregnation method for removal of U(VI) from aqueous solution and were characterized by transmission electron microscopy (TEM), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), Raman spectroscopy, Brunauer-Emmett-Teller (BET), and X-ray photoelectron spectroscopy (XPS). TNSs were introduced into the PDA/CNT composite, which effectively averted the agglomeration of the CNT and further exposed more adsorption sites. PDA thin layer exposing more active sites was conducive to enhance adsorption capacity and kinetic.

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Delayed wound healing in patients with diabetes remains a major health challenge worldwide. Uncontrolled bacterial infection leads to excessive production of reactive oxygen species (ROS) and persistent inflammatory responses, which seriously hinder conventional physiological healing processes after injury. Biofilms, as protective barriers for bacteria, pose a critical obstacle to effective bacterial eradication.

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Background: With the increasing demand for total hip arthroplasty (THA) and the inevitable trend of orthopedic robots and artificial intelligence in the future, it is necessary to explore the safety and effectiveness of orthopedic robots in THA. Currently, most orthopedic robots are in the early stages of development, and evaluating their clinical efficacy can assist in making informed decisions for practical use.

Objective: To explore the advantages of 7 types of robot-assisted THA with respect to 5 indicators.

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Introduction: Whether double filtration plasmapheresis (DFPP) is effective in the patients who do not response to the initial immunotherapy is uncertain. This retrospective study aimed to evaluate the efficacy and safety of DFPP in the treatment of patients who had no improvement after initial immunotherapy (steroids and/or immunoglobulin (IVIG)), and moreover, to investigate the factors associated with the efficacy of DFPP.

Methods: From January 1st, 2014, to December 30th,2018, a total of 26 patients who were diagnosed autoimmune encephalitis (AE) and were received the treatment of DFPP after unsuccessful or incomplete recovery from their early immune therapy (including intravenous high-dose cortisone, IVIG and or immunosuppressant) for at least 21 days were investigated.

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Article Synopsis
  • The study investigates the relationship between psoriasis and degenerative valvular heart disease (VHD), finding that both share common risk factors and inflammatory conditions.
  • Utilizing data from the UK Biobank, researchers analyzed the incidence of various types of VHD among participants with and without psoriasis over a median follow-up period of around 13.7 years.
  • Results showed that participants with psoriasis had a higher risk of developing aortic stenosis (AS), particularly among women, whereas no significant links were found for other forms of degenerative VHD.
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  • Cuproptosis is a newly discovered form of programmed cell death influenced by copper, and this research aims to investigate its relationship with Wilms tumor (WT) and related genes, ultimately creating a predictive model for WT.
  • Researchers analyzed four gene expression datasets from the GEO database to assess the expression of Cuproptosis-related genes (CRGs), uncover clusters of WT, and examine immune cell infiltration patterns in WT samples.
  • The study identified 13 significant CRGs associated with WT, discovered differences in immune cell presence compared to normal tissue, and determined that a support vector machine (SVM) model performed best in predicting WT risk using five specific genes, with validation through calibration and decision curve analyses.
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Accumulating evidence has revealed that chronic unresolved inflammation can cause significant tissue damage and can be a key mediator of advanced heart failure (HF). Resolvin (Rv) D2, a member of specialized pro-resolving lipid mediators (SPMs), plays a protective role in various diseases by facilitating resolution. However, whether RvD2 participates in the pathogenesis of HF is still unclear.

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The metabolism of arsenic (As) plays a crucial role in its health effects. However, the impact of arsenic methylation during early pregnancy on gestational diabetes mellitus (GDM) remains unclear. This study aimed to investigate the associations between As methylation in the first and second trimesters and the incidence of GDM by conducting a prospective cohort study in Chongqing, China.

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Organic cocrystals formed through multicomponent self-assembly have attracted significant interest owing to their clear structure and tunable optical properties. However, most cocrystal systems suffer from inefficient long-wavelength emission and low phosphorescence efficiency due to strong non-radiative processes governed by the energy gap law. Herein, an efficient long-lived red afterglow is achieved using a pyrene (Py) cocrystal system incorporating a second component (NPYC4) with thermally activated delayed fluorescence (TADF) and ultralong organic phosphorescence (UOP) properties.

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  • Precision oncology relies on biomarkers, with MGMT gene promoter methylation being a critical clinical biomarker for glioblastoma multiforme (GBM).
  • Time-consuming preanalytical processes like biospecimen storage and intratumor methylation variability can affect data reproducibility, but research showed that standard processing techniques do not significantly alter MGMT methylation assessment.
  • Despite consistent methods yielding reliable results, a significant portion of GBM specimens (26%-34%) displayed intratumor methylation heterogeneity, highlighting the necessity for multiple biopsies to accurately evaluate MGMT status.
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  • * Ferroptosis, a form of cell death tied to iron buildup and lipid damage, is linked to poor healing in diabetic wounds, as seen in studies on diabetic rat models and cultured macrophages.
  • * Treatment with ferrostatin-1 (Fer-1) has been shown to reduce ferroptosis and inflammation, boost cell growth, and facilitate new blood vessel formation, thereby improving diabetic wound healing, with effects linked to the activation of a protective factor called Nrf2.
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Background: Membranous nephropathy (MN) has not yet been fully elucidated regarding its relationship with Type I and II Diabetes. This study aims to evaluate the causal effect of multiple types of diabetes and MN by summarizing the evidence from the Mendelian randomization (MR) study.

Methods: The statistical data for MN was obtained from a GWAS study encompassing 7979 individuals.

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The high nitrogen content and diverse reactivity of malononitrile are widely harnessed to access nitrogen-rich fine chemicals. Although the facile substitutions of malononitrile can give structurally diverse quaternary carbons, their access to enantioenriched molecules, particularly chiral amines that are prevalent in bioactive compounds, remains rare. Here we report a cobalt-catalysed desymmetric reduction of disubstituted malononitriles to give highly functionalized β-quaternary amines.

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Article Synopsis
  • Recent studies show that fewer than two medications can help reach intensive blood pressure (BP) targets, focusing on a study involving 4,991 individuals from the Majiapu community.
  • The study found that 54% of participants had hypertension, and among those treated, 55.7% achieved BP control, with only 23.15% maintaining levels below 130/80 mm Hg.
  • Key factors affecting BP control included age, sex, obesity, and smoking history, indicating that patients on fewer medications for stricter targets might have a lower risk profile.
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Aims: Interleukin (IL)-12p40 is a common subunit of the bioactive cytokines IL-12 and IL-23, and it also has its own intrinsic functional activity. However, its role in doxorubicin-induced chronic cardiomyopathy (DICCM) as well as the underlying mechanisms are still unknown.

Methods And Results: In this study, we used IL-12p40-knockout mice, IL-23p19-knockout mice, Rag1-knockout mice, a ferroptosis inhibitor, recombinant IL-12 (rIL-12), rIL-23, rIL-12p40, rIL-12p80, and anti-IL17A to investigate the effects of IL-12p40 on DICCM and elucidate the underlying mechanisms.

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Article Synopsis
  • Obesity is a widespread issue linked to various metabolic disorders, and browning white adipose tissue (WAT) is seen as a potential treatment to help with weight loss and metabolic health.
  • Researchers developed a nanocomplex called pTSL@(P+I), which uses temperature-sensitive liposomes that target adipocytes and carry agents that promote browning and harness photothermal properties.
  • In studies with diet-induced obesity mice, this nanocomplex showed significant weight loss (14.4% reduction) and improved fat/lean mass ratio without major side effects, highlighting its potential as a targeted therapy for obesity.
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  • The research presents a comprehensive study on the transformations of metal-organic frameworks (MOFs), detailing their transition from crystalline to glassy states through various phases.
  • It highlights an innovative method of achieving MOF glasses via a self-perturbation strategy without melting the material, starting from a specific crystalline framework.
  • The findings demonstrate the successful selective separation of hydrocarbon gases using the resultant amorphous and glassy MOFs, achieving high purity levels, which has significant implications for gas separation technologies.
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