Edgeworthia gardneri (Wall.) Meisn Mitigates CCL4-induced liver injury in mice by modulating gut microbiota, boosting antioxidant defense, and reducing inflammation.

Herbal medicine has become an area of growing global scientific interest. The prime objective of this study was to investigate the protective role of Edgeworthia gardneri (Wall.) Meisn (EGM polysaccharide) against carbon tetrachloride (CCl)-induced liver injury in mice.

Lactated Ringer's solution versus saline fluid resuscitation for reducing PROGRESSION TO moderate-to-severe acute pancreatitis: a systematic review and meta-analysis.

Background: Fluid resuscitation represents a pivotal early therapeutic intervention in the management of acute pancreatitis (AP), yet a consensus on the optimal fluid type remains elusive. The present study endeavors to elucidate the differential effects of lactated Ringer's solution (LR) and normal saline (NS) in the initial treatment of AP.

Methods: A comprehensive literature search was conducted through the PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases, spanning from inception until July 2024.

Giant Capacitive Energy-Storage in BaTiO-Based Fine-Grained Relaxors via Local Polarization Enhancement.

Pb-free dielectric energy storage capacitors are core components in advanced pulse-power electronic systems and devices. However, the relatively low energy density (W) for the industrial pillar BaTiO (BT)-based capacitors remains a significant obstacle for their cutting-edge applications, due to their low intrinsic polarization and breakdown strength (E). Herein, through chemical composition and local structure design, a giant W of 15.

Design of a fragment crystallizable-engineered tetravalent bispecific antibody targeting programmed cell death-1 and vascular endothelial growth factor with cooperative biological effects.

Clinical studies have shown that combination therapy of PD-1 and VEGF antibodies significantly improves clinical benefit over PD-1 antibody alone in certain settings. Ivonescimab, an on-market tetravalent anti-PD-1/VEGF bispecific antibody, was designed to improve efficacy and safety over combo therapy. In this study, the mechanism of action is investigated.

Carbon dioxide alleviates platelet storage lesions via stimulating fatty acid metabolism and reducing platelet glucose consumption.

Background: The timely administration of platelet transfusions is critical for patient survival, and the clinical demand for platelet transfusions has been steadily increasing. However, platelet storage lesions (PSLs) that develop during preservation exacerbate these shortages. The PSL is significantly influenced by various factors, including temperature, gas composition, and buffering systems.

Electronic Localization Enables Long-Cycling Sulfides-Based All-Solid-State Lithium Batteries.

Argyrodite-based sulfide electrolytes have received considerable attention in all-solid-state lithium metal batteries owing to their high ionic conductivity and good mechanical property. However, the reactivity between sulfide electrolytes and lithium anode leads to continuous interfacial reactions and dendrites growth, which severely hinders their practical applications. We propose an electron localization strategy by modulating the d-p orbital hybridization within the PS tetrahedral structure of LiPSCl through homogeneous incorporation of yttrium (Y) and oxygen (O).

First Result for Dark Matter Search by WINERED.

The identity of dark matter has been a mystery in astronomy, cosmology, and particle theory for about a century. We present the first dark matter search with a high-dispersion spectrograph by using WINERED at the 6.5 m Magellan Clay telescope to measure the photons from the dark matter decays.

Rhamnogalacturonan-I domains from red dragon fruit pectin promote the proliferation of Bifidobacterium animalis.

Pectin-derived oligosaccharides, an important source of the new generation of prebiotics, have aroused widespread research. As per our previous study report, the rhamnogalacturonan-I (RG-I) type pectin of dragon fruit positively affects the proliferation of Bifidobacterium animalis subsp. Lactis 3296.

Similarities and differences in the response and molecular characteristics of peripheral sensory neurons associated with pain and itch.

Dorsal root ganglion (DRG) neurons are responsible for the primary detection and transmission of peripheral noxious stimuli, mainly pain and itch. However, as two distinct noxious sensations, how DRG neurons respond differently to and code pain and itch is still an attractive topic. Here, we investigate the response and activation spectrum of DRG neurons under peripheral pain and itch stimuli using two-photon calcium imaging and find differences in the response intensity to pain and itch between multisensory neurons (both pain and itch) and single-sensory neurons (either pain or itch).

Regulation of lipid metabolism: a new strategy for platelet storage.

Transfusions of platelets are often used as prophylaxis in patients with hematologic malignancies and as treatment for active bleeding. However, platelets are in short supply due to the fact that they could only be kept for 5-7 days in vitro and they lose some of their functionality as a result of platelet storage lesions. To address this issue, refrigeration, cryopreservation and platelet additive solutions have been researched to determine their abilities to extend platelet storage duration.

Comparison between arm port and chest port: A systematic review and meta-analysis.

Objective: This meta-analysis aimed to compare the efficacy and safety of arm ports (APs) and chest ports (CPs) in clinical practice.

Methods: Randomized controlled trials (RCTs), controlled clinical trials, and retrospective studies were searched in both English and Chinese databases, encompassing PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Database, and SinoMed up to November 27, 2023. Data analysis was performed using Stata 15.

Black Phosphorus Nanosheet-Based Composite Biomaterials for the Enhanced Repair of Infectious Bone Defects.

Infectious bone defects pose significant challenges in orthopedic practice, marked by persistent bacterial infection and ongoing inflammatory responses. Recent advancements in bone tissue engineering have led to the development of biomaterials with both antibacterial properties and the ability to promote bone regeneration, offering new solutions to these complex issues. Black phosphorus nanosheets (BPNS), a unique two-dimensional material, demonstrate exceptional biocompatibility, bioactivity, and antibacterial properties.

Regulating Chemical Bonds in Halide Frameworks for Lithium Superionic Conductors.

Developing solid-state electrolytes (SSEs) is a critical task for advancing all-solid-state batteries (ASSBs) that promise a high energy density and improved safety. The dominant strategy in engineering advanced SSEs has been substitutional doping, where foreign atoms are introduced into the atomic lattice of a host material to enhance ionic conduction. This enhancement is typically attributed to optimized charge carriers' concentration or lattice structure alterations.

Cooperative mechanisms of oxide ion conduction in tellurites with secondary bond interactions and Grotthuss-like processes.

Oxide-ion conducting materials are gaining considerable attention in various applications ranging from oxide fuel cells to oxygen permeation membranes. The oxide ion migration mechanisms are the basis for designing oxide-ion conducting materials. Here, enlightened by proton diffusion in hydrogen-bond networks, we report the coordination polyhedra cooperative mechanism with similar Grotthuss process of oxide ion migration in tellurites.

Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.

Reactive oxygen species exacerbate nonalcoholic steatohepatitis (NASH) by oxidizing macromolecules; yet how they promote NASH remains poorly understood. Here, we show that peroxidase activity of global hepatic peroxiredoxin (PRDX) is significantly decreased in NASH, and palmitic acid (PA) binds to PRDX1 and inhibits its peroxidase activity. Using three genetic models, we demonstrate that hepatic PRDX1 protects against NASH in male mice.

Extremely low lattice thermal conductivity in light-element solid materials.

Lattice thermal conductivity ( ) is of great importance in basic sciences and in energy conversion applications. However, low- crystalline materials have only been obtained from heavy elements, which typically exhibit poor stability and possible toxicity. Thus, low- materials composed of light elements should be explored.

Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer.

Inflammation can influence the development of CRC as well as immunotherapy and plays a key role in CRC. Therefore, this study aimed to investigate the potential of inflammation-related genes in CRC risk prediction. Inflammation gene models were constructed and validated by combining transcriptomic and single-cell data from TCGA and GEO databases, and the expression of inflammation-related genes was verified by RT-qPCR.

All-solid-state batteries designed for operation under extreme cold conditions.

A pressing need for enhancing lithium-ion battery (LIB) performance exists, particularly in ensuring reliable operation under extreme cold conditions. All-solid-state batteries (ASSBs) offer a promising solution to the challenges posed by conventional LIBs with liquid electrolytes in low-temperature environments. In this study, leveraging the benefits of amorphous solid-state electrolytes (SSEs) xLiN-TaCl (1 ≤ 3x ≤ 2), we develop ASSBs capable of functioning effectively under extreme cold conditions.

Helical dislocation-driven plasticity and flexible high-performance thermoelectric generator in α-MgBi single crystals.

Inorganic plastic semiconductors play a crucial role in the realm of flexible electronics. In this study, we present a cost-effective plastic thermoelectric semimetal magnesium bismuthide (α-MgBi), exhibiting remarkable thermoelectric performance. Bulk single-crystalline α-MgBi exhibits considerable plastic deformation at room temperature, allowing for the fabrication of intricate shapes such as the letters "SUSTECH" and a flexible chain.

Hemodynamic evaluation of symptomatic and asymptomatic intracranial atherosclerotic stenosis using cerebral angiographic images: an exploratory study.

Background: Previous studies suggest that it may be inappropriate to determine treatment strategies solely based on the degree of stenosis for patients with intracranial atherosclerotic stenosis (ICAS). In order to better risk stratify patients with ICAS, we developed a novel non-invasive fractional flow (FF) calculation technique based on intracranial angiography (Angio-FF) to assess the hemodynamics for patients with ICAS. This study aims to investigate the difference in FF between symptomatic and asymptomatic patients with ICAS and its potential optimal threshold.

Imaging observation of intervertebral disc degeneration in patients with old thoracolumbar fracture-related kyphotic deformity.

Old thoracolumbar fracture with kyphosis (OTLFK) often results in low back pain, with intervertebral disc degeneration being a significant contributor. We hypothesized that patients with OTLFK exhibit distinct patterns of disc degeneration compared to those with chronic low back pain without kyphotic deformity. This study aimed to investigate the characteristics of disc degeneration in OTLFK patients and explore its association with sagittal spinal parameters and endplate injury.

Kawasaki disease involving both the nervous system and cardiovascular system: a case report and literature review.

Background: Kawasaki disease (KD), an acute self-limiting vasculitis, is the main cause of acquired heart disease. Timely diagnosis and treatment can mitigate the occurrence of complications and improve patient prognosis. Facial nerve paralysis (FNP) and ptosis are rare complications of KD and are rarely reported, but FNP is considered a high risk factor for coronary aneurysms.

Regulating the Intralayer Cation Disorder in Layered Lithium-Rich Cathodes to Improve Cycle Performance.

The Li/Mn ordered structure of lithium-rich (LR) cathodes leads to the heterogeneous LiMnO and LiTMO components, readily triggering structural degeneration and performance degradation in long-term cycling. However, the lack of guiding principles for promoting cation disorder within the transition metal (TM) layers has posed a persistent challenge in designing homogeneous layered LR cathodes. Herein, the (Li + Mn) content in the TM layer as a criterion for the design of cation-disordered layered LR cathodes is proposed.

Ratiometric fluorescent paper chip for monitoring the freshness of high protein foods.

Accurately monitoring the freshness of high-protein foods has significant implications for both food safety and public welfare. Since a large amount of hydrogen sulfide (HS) is produced during spoilage-related processes, abnormal HS levels are often considered an important indicator of food spoilage. Therefore, we synthesized novel nanoparticles (NPs) containing Silicon (Si) dots and CdTe quantum dots to accurately assess the amount of sulfide ions (S) and thus the quality of high-protein foods in the early stage of storage.