Publications by authors named "Yin Qiang"

A straightforward, versatile, and efficient method for the asymmetric synthesis of 3-substituted isoindolinones is described. In this method, a series of ()-2-(-butylsulfinyl)-isoindolin-1-ones were synthesized from the corresponding methyl 2-formylbenzoates in two steps with overall yields of 71-78%. Deprotonation of these compounds using LDA and the subsequent alkylation of the resulting carbanions with various alkylating agents afforded a series of 3-substituted isoindolinones in excellent yields and high diastereomeric ratios.

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Background: Steroid-resistant asthma (SRA) is a form of asthma resistant to corticosteroid therapy, which is characterized by the presence of neutrophil-predominant inflammatory response and neutrophil extracellular traps (NETs) formation. Hyssopus cuspidatus Boriss., a traditional Uyghur medicine, is known for its efficacy in treating inflammatory lung conditions such as asthma.

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A novel analytical method was designed and developed that exhibited ultraviolet-visible (UV-Vis), fluorescence (FL), and resonance Rayleigh scattering (RRS) signals for straightforward and comprehensive determination of monoamine oxidase B (MAO-B) using polyethylenimine-functionalized silver nanoparticles (PEI-Ag NPs). Through a facile one-step experiment, and NaOH assisted, in an aqueous solution of 100 ℃ for 40 min PEI reacted with AgNO to generate PEI-Ag NPs with a yellow color and weak blue fluorescence. Interestingly, phenylacetaldehyde (PAA), a specific product of MAO-B, causes significant enhancement of the three optical signals of UV-Vis, FL, and RRS.

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Hirschsprung's disease (HSCR) is a congenital enteric neuropathic disorder characterized by high heritability (>80%) and polygenic inheritance (>20 genes). The previous genome-wide association studies (GWAS) identified several common variants associated with HSCR and demonstrated increased predictive performance for HSCR risk in Europeans using a genetic risk score, there remains a notable gap in knowledge regarding Chinese populations. We conducted whole exome sequencing in a HSCR case cohort in Chinese.

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Proteolysis Targeting Chimeras (PROTACs) are bifunctional compounds that have been extensively studied for their role in targeted protein degradation (TPD). The capacity to degrade validated or undruggable targets provides PROTACs with significant potency in cancer therapy. However, the clinical application of PROTACs is limited by their poor potency and unfavorable pharmacokinetic properties.

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Introduction: Aerobic composting is an effective method for utilizing chicken manure. However, its low carbon to nitrogen (C/N) ratio leads to slow heating and short high-temperature phases, which reduce composting efficiency and product quality.

Methods: To address this issue, splinted mushroom cultivation residues were added to adjust the C/N ratio, and exogenous thermophilic composting strains were introduced to increase composting temperature.

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Terpenoids derived from phytopathogenic fungi are major participants in interactions among microorganisms, plants, and animals. The modifications catalyzed by cytochrome P450s significantly influence the structural and bioactivity diversity of the terpenoids. To conduct genome mining of P450s in pathogenic fungi, in this study, we developed a new software called atural roducts iloring Enzymes enome ining (NPtagM).

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Enhancing the structural stability of an enzyme and maintaining its catalytic activity are effective ways to improve enzyme utilization and reduce the cost of drug screening. However, immobilized enzyme activity tends to decrease in existing immobilization techniques due to conformational changes and microenvironmental restrictions. In this paper, we present a facile approach to prepare immobilized acetylcholinesterase (AChE) with high activity by a ZIF-8 in situ immobilization and citric acid (CA) etching strategy.

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Article Synopsis
  • Psoriasis is a chronic skin disease linked to an abnormal immune reaction and oxidative stress, which can worsen due to sleep disturbances.
  • The Xiaoyin-Anshen formula (XYAS), a traditional Chinese medicine, shows promise in treating psoriasis, especially for patients suffering from sleep issues, but its exact effects are not fully understood.
  • A study using a mouse model aimed to investigate how XYAS influences melatonin levels, reduces oxidative stress, and mitigates psoriasis-like inflammation through a series of treatments and tests.
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Vegetation restoration has an important remodelling effect on near-surface characteristics, and consequent changes in land surface roughness (LSR) are key influences on soil wind erosion processes. However, the effects of vegetation restoration types and ages on LSR and the underlying mechanisms are not fully understood. In this study, the sand-fixing vegetation restoration area of the Hobq Desert was examined in comparison to a bare sand control area.

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Article Synopsis
  • - China's new urbanization strategy (NUPP) aims to boost sustainable urban development and has shown a significant positive impact on urban green total factor productivity (GTFP) across 276 cities from 2011 to 2019.
  • - Key factors that aid in enhancing GTFP are the coordination between population, land, and industry (PLICCD), as well as the relationship between industry, environment, and economy (IEECCD). These findings hold true even after thorough statistical analyses.
  • - The study recommends promoting new urbanization efforts, focusing on coordinated development in planning, and tailoring strategies to fit the unique characteristics of different cities to maximize GTFP improvements and guide sustainable urban policies.
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  • - Nonalcoholic fatty liver disease (NAFLD), particularly nonalcoholic steatohepatitis (NASH), is a common chronic liver condition, and the Yanxiao Di'naer formula (YXDNE) from Uyghur traditional medicine has been used historically to treat liver issues, though its effectiveness and mechanisms in NASH remain poorly defined.
  • - This study aimed to evaluate the effectiveness of YXDNE for treating NASH using a high-fat, high-cholesterol diet and carbon tetrachloride in mice, alongside detailed analysis of its components and mechanisms involving various metabolic pathways.
  • - Results indicated that YXDNE significantly improved NASH in mice by influencing fatty acid metabolism and activating key signaling
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Sesquiterpenoids served as an important source for natural product drug discovery. Although genome mining approaches have revealed numerous novel sesquiterpenoids and biosynthetic enzymes, the comprehensive landscape of fungal sesquiterpene synthases (STSs) remains elusive. In this study, 123 previously reported fungal STSs were subjected to phylogenetic analysis, resulting in the identification of a fungi-specific STS family known as trichodiene synthase-like sesquiterpene synthases (TDTSs).

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Background: Oxidative Balance Score (OBS) is a tool for assessing the oxidative stress-related exposures of diet and lifestyle. The study aimed to investigate the association between OBS and low muscle mass.

Methods: Overall, 6,307 individuals over the age of 18 were assessed using data from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES).

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Article Synopsis
  • The study focused on analyzing the molecular characteristics of the Omicron variant BA.2.76 of SARS-CoV-2 in Jining City, China, using whole-genome sequencing on 87 infected cases.
  • The results revealed that all sequences belonged to the BA.2.76 branch with minor differences from the original Wuhan strain, showing numerous amino acid variations, particularly in the spike protein.
  • The findings emphasize the ongoing evolution of SARS-CoV-2, highlighting the importance of genomic analysis for understanding the virus's transmission, immune evasion, and implications for COVID-19 prevention strategies.
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Vascular diseases, such as vascular malformations and hemangiomas, are often classified into "fast-flow" and "slow-flow" based on their internal blood velocity. Fast-flow vascular diseases of maxillofacial regions are a kind of complicated and dangerous pathological changes originating from or containing arteries, their treatment is often complex and different from disease to disease, and large amounts of intraoperative blood loss and poor operation field may cause side injury or other problems without a detailed map of the lesion. The authors use the combination of color Doppler ultrasound and three-dimensional computed tomography angiography to diagnose and classify 36 cases of maxillofacial fast-flow vascular diseases, from January 2018 to December 2022 presented in the authors' department.

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Background: Morgagni hernias are rare anomalies that are easily misdiagnosed or missed.

Aim: To summarize the ultrasound (US) imaging characteristics of Morgagni hernias through a comparison of imaging and surgical results.

Methods: The records of children with Morgagni hernias who were hospitalized at two hospitals between January 2013 and November 2023 were retrospectively reviewed in terms of clinical findings, US features, and operative details.

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  • The study focuses on the complex cellular microenvironment of colonic polyps in children, including solitary juvenile polyps (SJPs) and those associated with Peutz-Jeghers syndrome (PJS).
  • Researchers used single-cell RNA sequencing and immunohistochemistry to analyze tissue samples, revealing distinct cell types and expression patterns linked to each polyp type.
  • Key findings include increased presence of specific immune and epithelial cell types in the different polyp subtypes, with unique gene expression changes and enhanced cell communication indicative of disease-specific microenvironments.
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  • The study aimed to evaluate and compare the effectiveness of different treatments for laryngeal contact granulomas (LCG) by analyzing 45 patients from Xi'an Jiaotong University.
  • Three treatment groups were analyzed: acid suppression alone, hormone injection with acid suppression, and surgery with acid suppression, focusing on treatment effectiveness and healing time.
  • Results showed that hormone injection combined with acid suppression significantly improved healing rates and reduced healing time compared to acid suppression alone, while granuloma size was larger in patients with hoarseness.
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Objective: Three-dimensional (3D) printed models are used in the medical field. This study aimed to evaluate the feasibility and safety of a 3D-printed guide plate for use in brain biopsy.

Methods: Twelve patients with intracranial lesions were retrospectively reviewed to determine clinical outcomes and technical procedural operability.

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Background: Hugan Buzure Granule (HBG) is a traditional prescription of Uygur nationality in China mainly used to treat liver cold, stomachache, spleen and rib pain, arthralgia, rheumatism and urinary system diseases. Its mechanism of action in treating acute kidney injury (AKI) continues to remain unconfirmed. This study's objective was to investigate the pharmacodynamics and mechanism of HBG in the management of AKI.

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The Fe-based Fischer-Tropsch synthesis (FTS) catalyst shows a rich phase chemistry under pre-treatment and FTS conditions. The exact structural composition of the active site, whether iron or iron carbide (FeC), is still controversial. Aiming to obtain an insight into the active sites and their role in affecting FTS activity, the swarm intelligence algorithm is implemented to search for the most stable Fe(100), Fe(110), Fe(210) surfaces with different carbon ratios.

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The unique magnetic field environment during electromagnetic launch imposes higher requirements on the design and protection of the internal electronic system within the launch load. This low-frequency, Tesla-level extreme magnetic field environment is fundamentally distinct from the Earth's geomagnetic field. The excessive change rate of magnetic flux can readily induce voltage within the circuit, thus disrupting the normal operation of intelligent microchips.

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Reuterin can be produced from glycerol dehydration catalyzed by glycerol dehydratase (GDHt) in and has broad application prospects in industry, agriculture, food, and other fields as it is active against prokaryotic and eukaryotic organisms and is resistant to proteases and lipases. However, high concentrations of glycerin inhibit reuterin production, and the mechanism behind this phenomenon is not clear. To elucidate the inhibitory mechanism of glycerol on reuterin synthesis in and provide reference data for constructing an culture system for highly effective 3-hydroxypropionaldehyde synthesis, we used transcriptome-sequencing technology to compare the morphologies and transcriptomes of cultured in a medium with or without 600 mM of glycerol.

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We aimed to examine impacts and functional mechanism of circular RNA forkhead box N2 (FOXN2) in tacrolimus (TAC)- and dexamethasone (Dex)-induced lipid metabolism disorders. RNA level and protein contents in TAC, Dex, or combined TAC- plus Dex-treated patients and Huh-7 cells were measured utilizing quantitative real-time (qRT)-PCR and western blotting assays measured the formation of lipid droplet. Total cholesterol (TC) and triglyceride (TG) levels were determined using corresponding commercial kits and Oil red O staining.

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