Publications by authors named "Yin Pu Shi"
Dysregulation of glucose homeostasis contributes to insulin resistance and type 2 diabetes. Whilst exercise stimulated activation of AMP-activated protein kinase (AMPK), an important energy sensor, has been highlighted for its potential to promote insulin-stimulated glucose uptake, the underlying mechanisms for this remain largely unknown. Here we found that AMPK positively regulates the activation of Rab5, a small GTPase which is involved in regulating Glut4 translocation, in both myoblasts and skeletal muscles.
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- Rab5a is essential for muscle regeneration and is upregulated during myogenesis, indicating its critical role in skeletal muscle development.
- Rab5a promotes myoblast differentiation by interacting with insulin receptor substrate 1 (IRS1), particularly upon activation of IGF-1, and this interaction is crucial for effective signaling.
- The study reveals that Rab5a regulates the AKT-mTOR signaling pathway through its interaction with IRS1, highlighting its importance in coordinating muscle regeneration processes.
The regenerative process of injured muscle is dependent on the fusion and differentiation of myoblasts derived from muscle stem cells. Hsp70 is important for maintaining skeletal muscle homeostasis and regeneration, but the precise cellular mechanism remains elusive. In this study, we found that Hsp70 was upregulated during myoblast differentiation.
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