Gibberellin regulates the synthesis of stone cells in 'Nanguo' pear via the PuMYB91-PuERF023 module.

Stone cells are one of the limiting factors affecting pear fruit quality and commodity value. The formation of stone cell is highly correlated with lignin deposition. However, the molecular mechanism of stone cell formation and regulation is still unclear.

Optimizing Post-activation Performance Enhancement in Athletic Tasks: A Systematic Review with Meta-analysis for Prescription Variables and Research Methods.

Background: Post-activation performance enhancement (PAPE) has demonstrated efficacy in acutely improving athletic performance. However, its distinction from general warm-up (GW) effects remains ambiguous, and experimental designs adopted in most PAPE studies exhibit important limitations.

Objectives: The aims of this work are to (i) examine the effects of research methodology on PAPE outcomes, (ii) explore PAPE outcomes in relation to comparison methods, performance measures, GW comprehensiveness, recovery duration, participants' characteristics, conditioning activity (CA) parameters, and (iii) make recommendations for future PAPE experimental designs on the basis of the results of the meta-analysis.

Construction and Development of an Enhanced Recovery After Surgery Program for the Surgical Management of Patients With Spinal Metastasis: A Modified Delphi Study.

Objective: As an effective treatment for spinal metastasis (SM), ERAS protocol can significantly reduce the length of hospital stay and complications in patients. Establishing an ERAS program for perioperative care after SM surgery is a clinical problem that needs to be addressed urgently. We aimed to develop an Enhanced Recovery After Surgery (ERAS) program and Surgical Safety Checklist (SSC) that conferred clinical benefit to patients with SM and made it relatively easy to manage the condition.

The piR-31115-PIWIL4 complex promotes the migration of the triple-negative breast cancer cell lineMDA-MB-231 by suppressing HSP90AA1 degradation.

Background: P-element-induced wimpy testis (PIWI) proteins bind to PIWI-interactingRNAs (piRNAs) to form the piRNA/PIWI complex, which affects protein regulation. PIWIL4, a member of the PIWI family, has been demonstrated in recent studies to promote the migration of triple-negative breast cancer (TNBC) cell line MDA-MB-231. However, the molecular mechanisms underlying cell migration remain obscure.

A meta-analysis of the effects of nitrogen fertilizer application on maize ( L.) yield in Northwest China.

Nitrogen fertilizer application is an important method for the production of high-quality maize. However, nitrogen fertilizer addition patterns vary according to regional climate, field management practices, and soil conditions. In this study, a meta-analysis was used to quantify the yield effects of nitrogen addition on maize, and meta-regression analysis and a random forest model were used to study the main factors affecting the yield effects of nitrogen addition on maize.

Narcolepsy in early childhood: a case report and a Mini review.

Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.

Genome mining of albocandins A-E from sp. YINM00030.

The natural products of 2,5-diketopiperazines have attracted considerable attention due to their potent pharmacological activities. Guided by genome mining techniques, five albonoursin analogues, designated as albocandins A-E (1-5), were isolated from sp. YINM00030, an actinomycete sourced from the rhizosphere soil of medicinal plants.

Administration of non-national immunization program vaccines for children under six in a rural county, Henan Province: Did costs matter?

This study aimed to investigate caregivers' administration of non-National Immunization Program (NIP) vaccines in rural China, and examine health system, individual, and social determinants. A cross-sectional survey ( = 1051) was conducted from July to October in 2022 in a rural county of Henan Province. Caregivers of children under six who came to township health centers for child vaccination were interviewed.

FLOWERING LOCUS C-like mediates low-ambient-temperature-induced late flowering in chrysanthemum.

The flowering time of Chrysanthemum morifolium predominantly depends on day length but is also sensitive to ambient temperature. However, the mechanisms underlying the response of chrysanthemum to ambient temperature are mainly unknown. This study identified a MADS-box transcription factor called CmFLC-like, a representative low ambient temperature-responsive factor induced in chrysanthemum leaves and shoot apical meristems at 15°C.

Comparative Study of Frailty Assessment Measures in Predicting All-Cause Mortality: Insights From NHANES.

Objectives: The 3 most frequently utilized frailty assessment measures are the Fried criteria, FRAIL scale, and Frailty Index (FI). This study aimed to compare predictive capabilities of these 3 measures regarding all-cause mortality in the United States and to identify the key predictive variables.

Design: Cross-sectional study.

An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord.

Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. Gene reprogramming and tissue remodeling in the dorsal root ganglia (DRG) and spinal cord (SC) drive the development and maintenance of neuropathic pain (NP). However, our understanding of the NP-associated spatial molecular processing landscape of SC and the non-synaptic interactions between DRG neurons and SC cells remains limited.

Preparation of a Self-Assembled Nanoantiviral Pesticide with Strong Adhesion Performance for Efficiency Control of Destructive .

In this context, we reported for the first time the design and development of a self-assembled nanoantiviral pesticide based on the star polycation (SPc) and the broad-spectrum fungicide/antiviral agent seboctylamine for field control of (SMV), a highly destructive plant virus in soybean crops. The SPc could self-assemble with seboctylamine through hydrogen bonds and van der Waals forces, and the complexation with SPc reduced the particle size of seboctylamine to form a spherical seboctylamine/SPc complex. In addition, the contact angle of seboctylamine decreased, and its retention increased with the aid of SPc, indicating excellent wetting properties and strong leaf surface adhesion performance.

First-principles study of CO and HO adsorption on the anatase TiO(101) surface: effect of Au doping.

Photocatalytic reduction of CO will play a major role in future energy and environmental crisis. To investigate the adsorption mechanisms of CO and HO molecules involved in the catalytic process on the surface of anatase titanium dioxide 101 (TiO(101)) and the influence of Au atom doping on their adsorption, first-principles density functional theory calculations were used. The results show that 1.

Dectin-2 depletion alleviates osteoclast-induced bone loss in periodontitis via Syk/NOX2/ROS signaling.

Periodontitis is the sixth most common disease worldwide and is closely associated with various systemic diseases, impacting overall health. It is characterized by the over-differentiation and activity of osteoclasts, leading to increased bone resorption and subsequent bone loss. Current treatments for bone loss are not ideal, highlighting the need for new targeted therapeutic strategies.

Combining metagenomic sequencing and molecular docking to understand signaling molecule degradation characteristics of quorum quenching consortia.

Quorum quenching consortia (QQC) enriched by special substrates for bioaugmentation is a promising QQ technology to reduce biofouling, sludge yield, and sludge bulking. However, the effect of substrate type on the performance of QQC is still a research gap. This study selected three different substrates, regular AHLs (N-octanoyl-l-homoserine lactone, C8), 3-oxo-AHLs (3-oxo-octanoyl)-l-homoserine lactone, 3-oxo-C8), and AHLs analogs (γ-caprolactone, GCL) to enrich three QQC (C8-QQC, 3OC8-QQC, GCL-QQC).

Comparative Analysis of Biochemical Parameters, Thermal Behavior, Rheological Features, and Gelling Characteristics of Thai Ligor Hybrid Chicken and Broiler Meats.

Genetic differences typically cause differences in the structure and function of proteins in meat. The objective of this research was to examine the biochemical characteristics and functional behavior of proteins in fresh composite meat from Thai Ligor hybrid chicken (LC) and commercial broiler chicken (BC). The composite meat samples, which comprise minced breast and thigh without skin from 20 chicken carcasses in a 1:1 (/) ratio, were randomly selected for analysis using the completely randomized design (CRD).

All-perovskite tandem solar cells achieving >29% efficiency with improved (100) orientation in wide-bandgap perovskites.

Monolithic all-perovskite tandem solar cells present a promising approach for exceeding the efficiency limit of single-junction solar cells. However, the substantial open-circuit voltage loss in the wide-bandgap perovskite subcell hinders further improvements in power-conversion efficiency. Here we develop wide-bandgap perovskite films with improved (100) crystal orientation that suppress non-radiative recombination.

Changes in flavor quality of marinated Chinese mitten crab (Eriocheir sinensis) with vacuum pack during cold storage.

In order to study the pattern of changes in quality of marinated Chinese mitten crabs (Eriocheir sinensis) during cold storage, three aspects of sensory, taste and odor were investigated. Sensory evaluation and total volatile basic nitrogen (TVB-N) were measured in viscera and abdomen muscle at 0, 7, 15 and 30 days of storage at 4°C. Sensory scores significantly declined at 15 d, coinciding with TVB-N levels exceeding 25 mg N/100 g.

Advanced Imaging Techniques for Assessing Fat, Iron, and Fibrosis in Chronic Liver Disease.

Imaging plays a critical role in the management of chronic liver disease (CLD) because it is a safe and painless method to assess liver health. The widely used imaging techniques include ultrasound, computed tomography and magnetic resonance imaging. These techniques allow the measurement of fat deposition, iron content, and fibrosis, replacing invasive liver biopsies in many cases.

Folic Acid-Targeted Mixed Pluronic Micelles for Delivery of Triptolide.

The present study aimed to explore an ideal delivery system for triptolide (TPL) by utilizing the thin-film hydration method to prepare drug-loaded, folate-modified mixed pluronic micelles (FA-F-127/F-68-TPL). Scanning electron microscopy and atomic force microscopy showed that the drug-loaded micelles had a spherical shape with a small particle size, with an average of 30.7 nm.

Effect of Heat Treatment on the Microstructure and Property of Metastable β Titanium Alloy.

TB18 is a newly developed high-strength metastable β-titanium alloy, commonly used in aerospace structural materials, which demands high mechanical performance. By altering the alloy's microstructure, heat treatment can affect its mechanical characteristics. The alloy was solution treated for one to four hours at 870 °C in order to examine the impact of solution treatment duration.

Development of a prognostic nomogram model for predicting outcomes in benign esophagogastric anastomotic stenosis treated with fluoroscopic balloon dilation.

Objective: This study aims to evaluate the clinical utility and effectiveness of a nomogram model in predicting outcomes for patients with benign esophagogastric anastomotic stenosis (BES) undergoing fluoroscopic balloon dilation (FBD).

Methods: The clinical data of 428 patients with BES who received FBD treatment at our hospital between January 2013 and June 2023 were retrospectively analyzed. The patients were divided into training and validation cohorts in a 7:3 ratio.

Characterizing progenitor cells in developing and injured spinal cord: Insights from single-nucleus transcriptomics and lineage tracing.

Various mature tissue-resident cells exhibit progenitor characteristics following injury. However, the existence of endogenous stem cells with multiple lineage potentials in the adult spinal cord remains a compelling area of research. In this study, we present a cross-species investigation that extends from development to injury.

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis.

Acupuncture Point Embedding Therapy is a comprehensive treatment method that combines modern biomaterials with acupuncture techniques. Acupoint catgut embedding (ACE) not only avoids the adverse reactions associated with Western medicine but also incorporates the benefits of traditional acupuncture, extending the duration of its therapeutic effects. Allergic rhinitis (AR) is a condition known for its challenging treatment and tendency to persist.