The BS/BSOB Ratio in Aneuploidy Fetuses at 11-13 Weeks Gestation.

Objective: The posterior fossa of normal fetuses was evaluated and compared with those having chromosomal abnormalities at 11-13+6 weeks' gestation in Chinese population.

Methods: In 518 normal fetuses referred to first trimester screening, fetal brain stem (BS) and brain stem to occipital bone distance (BSOB) were measured prospectively. The BS and BSOB were also measured on stored images in fetuses with confirmed trisomy 21 (n = 38), Trisomy 18 (n = 26), Trisomy 13 (n = 8), and monosomy X (n = 8).

Extended first-trimester screening using multiple sonographic markers and maternal serum biochemistry: a five-year prospective study.

Objective: To examine the performance of first-trimester screening test combining several fetal sonographic and maternal biochemical markers for major aneuploidy in a Chinese population.

Methods: This was a prospective study performed over 5 years between January 2005 and December 2010 in Taiwan, with 20,586 cases that had a combination of a variety of sonographic markers and maternal serological β-human chorionic gonadotropin and pregnancy-associated plasma protein-A levels assessed at first trimester screening between 11(+0) and 13(+6) weeks of gestation. The risk of aneuploidy was calculated using algorithm software developed by Fetal Medicine Foundation, London.

The fetal frontomaxillary facial angle in normal and trisomy 21 ultrasounds at 11-13(+6) weeks of gestation: findings among the ethnic Chinese compared with Caucasian.

Objective: The aim of this research was to compare the fetal frontomaxillary facial (FMF) angle between normal and trisomy 21 fetuses at 11(+0) -13(+6)  weeks gestation in a Chinese population.

Methods: A prospective observational study was performed that included 640 euploid and 45 trisomy 21 singleton pregnancies undergoing first trimester ultrasound screening between 11 and 13(+6)  weeks of gestation. The FMF angle was measured in the midsagittal plane using the standard technique.

Nonlinear analysis of heart rate dynamics in hyperthyroidism.

Studies on the physiology of the cardiovascular system suggested that the generation of the heart rate signal is governed by nonlinear chaotic dynamics. No study investigated the nonlinear dynamics of heart rate in hyperthyroidism. We examined whether the heart rate dynamics of hyperthyroid patients is different from normal controls by the nonlinear analysis of heart rate variability (HRV) with correlation dimension (CD).

Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability.

Objective: The clinical manifestations of hyperthyroidism resemble those of the hyperadrenergic state. This study was designed to evaluate the impact of hyperthyroidism on the autonomic nervous system (ANS) and to investigate the relationship between serum thyroid hormone concentrations and parameters of spectral heart rate variability (HRV) analysis in hyperthyroidism.

Design And Patients: Thirty-two hyperthyroid Graves' disease patients (mean age 31 years) and 32 sex-, age-, and body mass index (BMI)-matched normal control subjects were recruited to receive one-channel electrocardiogram (ECG) recording.