Intellectual property protection as catalyst for radical technological innovation in national research program teams through innovation milieu and group potentials.

Based on the innovation-driven theory and the ability-motivation-opportunity (AMO) perspective, we explore the role of intellectual property protection (IPP) in enhancing the radical technological innovation (RTI) of national research project teams (NRPT). Survey data from 336 national research project team members from universities and enterprises were used to analyze the theoretical model of this study, bringing in the chain-mediated effects of innovation milieu (IM) and group potential (GP) for analysis, as well as two-stage hybrid partial least squares structural equation modeling (PLS-SEM) and artificial neural network techniques (ANN) to evaluate the hypotheses. The empirical findings of this paper show that the strength of IPP has a positive relationship with RTI of NRPT, and that IPP is the most important predictor of this.

Study examining the significant role of intellectual property protection in driving radical technological innovation among national research project teams, employing PLS-SEM and ANN modeling.

This study examines the role of intellectual property protection (IPP) in enhancing radical technological innovation (RTI) within national research project teams, using an innovation-driven theory and an ability-motivation-opportunity (AMO) perspective. This study utilizes a sample of 336 national research project team members from various Chinese universities, research institutes, and corporations to analyze the theoretical model. Additionally, a two-stage hybrid partial least squares structural equation modeling (PLS-SEM) approach, combined with artificial neural network techniques (ANN), is employed to evaluate the hypotheses.

Non-linear ground deformation detection and monitoring using time series InSAR along the coastal urban areas of Pakistan.

Conventional geodetic methods rely on point measurements, which have drawbacks for detecting and tracking geologic disasters at specific locations. In this study, the time series Interferometric Synthetic Aperture Radar (InSAR) approach was incorporated to estimate non-linear surface deformation caused by tectonic, shoreline reclamation, and other anthropogenic activities in economically important urban regions of Pakistan's southern coast, which possesses around 270 km. The shoreline is extended from the low-populated area on the premises of the Hub River in the west to the highly populated Karachi City and Eastern Industrial Zone, where we collected the Sentinel-1A C-band data from 2017 to 2023 to address urban security and threats to human life and property.

Efficient Functionalization of Organosulfones via Photoredox Catalysis: Direct Incorporation of -Carbonyl Alkyl Side Chains into -Allyl--Ketosulfones.

A novel and efficient method for functionalizing organosulfones has been established, utilizing a visible-light-driven intermolecular radical cascade cyclization of -allyl--ketosulfones. This process employs -Ir(ppy) as the photoredox catalyst and -carbonyl alkyl bromide as the oxidizing agent. Via this approach, the substrates experience intermolecular addition of -carbonyl alkyl radicals to the alkene bonds, initiating a sequence of C-C bond formations that culminate in the production of organosulfone derivatives.

Analysis of 16s rRNA Gene Sequencing in Feces: The Impact of Bariatric Surgery on the Gut Microbiota in Patients with Obesity.

Purpose: Obesity is a risk factor for many chronic diseases. This study aimed to investigate the effect of bariatric surgery on the gut microbiota from patients with obesity.

Materials And Methods: The microbiota composition from stool samples before and after bariatric surgery were identified using bacterial 16S rRNA gene sequencing.

Study on Dynamic Crack Expansion and Size Effect of Back-Filling Concrete under Uniaxial Compression.

With the continuous expansion of the application range of gob-side entry retaining technology, the depth, height, and advancing speed of coal seams also increase, which brings great problems to the stability control of surrounding rock structures of gob-side entry retaining. As one of the main bearing structures of the surrounding rock, the stability of the roadway-side support body is a key factor for the success of gob-side entry retaining. In order to study the deformation characteristics and instability mechanism of roadway-side support body, based on the roadway-side support materials of gob-side entry retaining, the dynamic expansion test of back-filling concrete cracks under uniaxial compression was carried out.

Elucidating performance failure in the use of an Anaerobic-Oxic-Anoxic (AOA) plug-flow system for biological nutrient removal.

The Anaerobic-oxic-anoxic (AOA) process is a carbon-saving and high-efficiency way to treat municipal wastewater and gets more attention. Recent reports suggest that in the AOA process, well-performed endogenous denitrification (ED), conducted by glycogen accumulating organisms (GAOs), is crucial to advanced nutrient removal. However, the consensuses about starting up and optimizing AOA, and in-situ enriching GAOs, are still lacking.

Investigating the change in gene expression profile of blood mononuclear cells post-laparoscopic sleeve gastrectomy in Chinese obese patients.

Background: Laparoscopic sleeve gastrectomy (LSG) is a sustainable technique that effectively treats morbid obesity. However, the molecular mechanisms underlying the improvement of metabolic health following this process warrants more investigation. This study investigates LSG-related molecules and uses bulk RNA-sequencing high-throughput analysis to unravel their regulatory mechanisms.

Metal-Free Photochemical Radical Cyclization for the Synthesis of Pyrrolo[3,2-c]-quinolines with One-Carbon Unit.

An efficient and environmentally-friendly method for carbon-centered radical cyclization of olefins via visible light photoredox catalysis to afford pyrrolo[3,2-c]-quinolines, oxindoles and quinoline-2,4-diones is described. This novel reaction successfully activated the α C-H bonds in one-carbon units such as esters, chlorinated hydrocarbons and cyano compounds via HAT (hydrogen atom transfer) process by means of aryldiazonium salts. The transformation features good functional group tolerance, broad substrate scope, high atom economy, no need for transition metal or high temperature.

Recent advances in aptamer-based targeted drug delivery systems for cancer therapy.

The past decade has become an important strategy in precision medicine for the targeted therapy of many diseases, expecially various types of cancer. As a promising targeted element, nucleic acid aptamers are single-stranded functional oligonucleotides which have specific abilities to bind with various target molecules ranging from small molecules to entire organisms. They are often named 'chemical antibody' and have aroused extensive interest in diverse clinical studies on account of their advantages, such as considerable biostability, versatile chemical modification, low immunogenicity and quick tissue penetration.

Damage Evolution Characteristics of Back-Filling Concrete in Gob-Side Entry Retaining Subjected to Cyclical Loading.

The back-filling body in the gob-side entry retaining is subject to continuous disturbance due to repeated mining. In this study, uniaxial and cyclical loading tests of back-filling concrete samples were carried out under laboratory conditions to study damage evolution characteristics with respect to microscopic hydration, deformation properties, and energy evolution. The results showed that, due to the difference in the gradation of coarse and fine aggregates, the cemented structure was relatively loose, and the primary failure modes under cyclical loading were tensile and shearing failure, which significantly decreased its strength.

Various unique coordination patterns of Hg and DFT calculations to determine the formation of a 3-D supramoleculer framework by covalent and noncovalent interactions.

By combining a large pi-conjugated bidentate ligand L: 3,6-dipyrazole-N-ethylcarbazole with HgI(2), an extraordinary supramolecular coordination polymer, [Hg(4)L(2)I(8)](infinity), has been prepared. The crystal structures of the ligand and its coordination polymer were determined by X-ray crystallography, which shows three varied coordination modes especially the rare asymmetric quadruply bridged trinuclear moieties in [Hg(4)L(2)I(8)](infinity). Density functional theory (DFT) calculations (ADF) performed on model dimers show the roles of covalent and noncovalent interactions in establishing the three-dimensional architecture.