[Progress of researches on acupuncture treatment of spinal cord injury by regulating programmed cell death].

Spinal cord injury (SCI) is a highly disabling disease of the central nervous system, and seriously affects the patients' quality of life. A large number of studies have shown that programmed cell death (PCD) is an important pathological mechanism of secondary injury in SCI. As a non-drug therapy, acupuncture therapy has the characteristics of bidirectional, holistic and multi-level actions, which can target PCD pathways to play a neuroprotective effect, and has great potential in regulating PCD in the treatment of SCI.

[Electroacupuncture of "Jiaji" (EX-B2) inhibits inflammatory response by regulating HMGB1/TLR4/NF-κB signaling pathway in rats with spinal cord injury].

Objectives: To observe the effect of electroacupuncture (EA) of "Jiaji" (EX-B2) on expression of high mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) related proteins and inflammation-related factors in spinal cord injury (SCI) rats, so as to explore the dynamic process of inhibiting inflammatory response in rats with SCI, and to provide a new idea and theoretical basis of molecular biology for the treatment of SCI.

Methods: Fifty-four SD rats were randomly divided into sham operation, model, and EA groups (=18 in each group), which were further divided into 3 d, 7 d and 14 d subgroups, with 6 rats at each time point. The SCI model was established according to the Allen's method.

['s experience in treatment of cerebral infarction in the recovery period with "brain electric field" therapy].

The "brain electric field" therapy is a novel electroacupuncture method created by Professor to treat cerebral infarction in the recovery period. This therapy is suitable for the treatment of motor disorders, sensory disorders, cognitive disorders, hemianopsia and bulbar paralysis during the recovery period of cerebral infarction. Based on the different symptoms, the corresponding brain functional areas are selected, supplemented with Taiyang 2, Tunyan 2, Tiyan, Gongxue and Xiatianzhu.

From apoptosis to pyroptosis: A two-decade analysis of spinal cord injury systematic review.

Background: Spinal cord injury has a significant impact on patients' physical and mental health, with cell death playing a key role in the pathology.

Methods: The Web of Science Core Collection database was searched and screened according to inclusion criteria for publications between January 1, 2000 and December 31, 2023. Bibliometric analysis was conducted using bibliomatrix R-package, CiteSpace, and VOSviewer software.

[Neuro-endocrine-immune network mechanism of acupuncture for post-stroke depression].

The nervous, endocrine and immune systems are interconnected through neurotransmitters, endocrine hormones and cytokines, forming a neuro-endocrine-immune (NEI) network that outputs effect information to target organs in a multi-level and multi-system manner. The effects of acupuncture can be amplified through the NEI network, causing local microenvironment responses at acupoints to treat post-stroke depression (PSD). This paper systematically elucidates the mechanisms of acupuncture treatment for PSD from three aspects: nervous, endocrine and immune, and reveals the potential mechanisms and biological pathways of acupuncture treatment for PSD from an overall perspective based on the NEI network, aiming to provide a reliable theoretical basis for fundamental research on acupuncture treatment for PSD.

Research progress on the mechanism of acupuncture on type Ⅱ diabetes mellitus.

Acupuncture is an effective measure for treating type 2 diabetes mellitus (T2DM). Many studies have shown that acupuncture can reduce blood glucose in patients with T2DM, but its mechanism is still unclear. This review summarized the mechanism of acupuncture on T2DM, the mechanisms of acupuncture in treating T2DM is related to improving insulin resistance, regulating inflammation, promoting insulin secretion, improving lipid metabolism disorders, resisting oxidative stress, improving obesity, controlling intestinal flora, and regulating the nervous system.

Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis.

A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation therapy has shown great potential in the reconstruction of damaged spinal cords and promoting functional recovery. However, there is a lack of frontiers and futures analysis in the study of cell transplantation in TSCI.

Exploring the role of gut microbiota in migraine risk: a two-sample Mendelian randomization study.

Objectives: The presence of intestinal flora in the gut has been linked to migraines in recent studies, but whether the association is causal or due to bias remains to be clarified. We aimed to explore whether there is a potential causal relationship between gut microbiota and migraine risk with this study.

Materials And Methods: We conducted a two-sample Mendelian randomized analysis study to explore whether gut microbiota has a causal relationship with migraine using publicly available data from large-scale genome-wide association studies.

Professor 's clinical experience of using electroacupuncture for dry eye.

The academic thoughts of professor regarding the use of electroacupuncture in the treatment of dry eye are introduced. Professor believes that the occurrence of dry eye is mainly related to the stagnation of and blood in the eye meridians, leading to inadequate nourishment of the eyes. The acupuncture treatment principle focuses on promoting blood circulation, clearing and benefiting the eye orifices.

Trends and hotspots of acupuncture for allergic rhinitis: A bibliometric analysis from 2002 to 2022.

Objective: The study aims to investigate and visualize the hotspots of acupuncture for Allergic rhinitis (AR) over the past two decades and pinpoint future trends in this field.

Method: We conducted a systematic search of English-language articles or reviews on acupuncture for AR in the Web of Science Core Collection from 2002 to 2022. Using Citespace, VOSviewer, and Bibliometrix, we analyzed and visualized the publications, countries, institutions, authors, journals, and keywords from various angles.

[Research progress on the effect mechanism of acupuncture-moxibustion for pressure injuries].

Evidence shows that acupuncture-moxibustion could promote the healing of pressure injuries (PI), but its action mechanism is not fully understood. This review summarizes the basic research literature of acupuncture-moxibustion for PI and identifies that the mechanism of acupuncture-moxibustion for PI is related with regulation of related signaling pathway target proteins, improvement of inflammatory response, modulation of vascular microenvironment, attenuation of oxidative stress damage, and inhibition of cell apoptosis. The review also points out the current limitations and future research directions.

Efficacy of acupuncture on acute pharynx infections: A systematic review and meta-analysis.

Background: Several clinical reports have focused on acupuncture for the treatment of acute pharyngeal infections. However, the efficacy and safety of acupuncture for the treatment of acute pharyngeal infections are controversial. To systematically assess the efficacy and safety of acupuncture in treating acute pharynx infections, thus providing a reference for clinical decision-making.

[Progress of researches on acupuncture treatment of allergic rhinitis].

Acupuncture therapy has been widely used in clinical treatment of allergic rhinitis (AR), and can induce a positive therapeutic effect through multi-targets and multi-aspects. In recent 10 years, the research on the mechanisms of acupuncture in treating AR mainly focused on humoral immunity, cellular immunity, cell apoptosis, inflammatory mediators and factors, neuropeptides, etc. By regulating the level of immunoglobulin in the blood, acupuncture intervention can restore the relative balance of cellular immune response, reduce the accumulation of eosinophils and promote apoptosis, down-regulate the expression of related inflammatory mediators and factors, regulate the excitability of related nerves, modulate the release of neuropeptides and other ways to diminish the inflammatory reaction of nasal mucosa, and enhance the repair and protection of nasal mucosa, relieve the nasal symptoms at last.

Efficacy of different acupuncture therapies on postherpetic neuralgia: A Bayesian network meta-analysis.

Background: Postherpetic neuralgia (PHN) is a common, complex, and refractory type of neuropathic pain. Several systematic reviews support the efficacy of acupuncture and related treatments for PHN. Nevertheless, the efficacy of various acupuncture-related treatments for PHN remains debatable.

['s clinical experience of electric eye acupuncture and stagnant-moving needling for ophthalmopathy].

Professor 's clinical experience of electric eye acupuncture and stagnant-moving needling for ophthalmopathy was introduced. The indications of electric eye acupuncture and stagnant-moving needling include external ophtalmoplegia and visual impairment. Professor has proposed new acupoints at the ocular muscles attachment of eyeball, and put forward five experience points: Shangming point, Neiming point, Xiaming point, Waiming point and Tijian point.

Poststroke Cognitive Impairment Research Progress on Application of Brain-Computer Interface.

Brain-computer interfaces (BCIs), a new type of rehabilitation technology, pick up nerve cell signals, identify and classify their activities, and convert them into computer-recognized instructions. This technique has been widely used in the rehabilitation of stroke patients in recent years and appears to promote motor function recovery after stroke. At present, the application of BCI in poststroke cognitive impairment is increasing, which is a common complication that also affects the rehabilitation process.

Gamma delta (γδ) T cells in cancer immunotherapy; where it comes from, where it will go?

Cancer immunotherapy is a field of interest in the recent treatment approaches against cancer cells, as it could use the assets of the host's immune system against the invading tumor cells. In cancer immunotherapy, for a while, αβT cells play fundamental roles; however, their dependence on major histocompatibility complex (MHC), their ability to only recognize mutated peptides, as well as their low tropism to the tumor sites, especially in solid tumors, have put an obstacle on their way into the clinical settings. Currently, a renewed interest has focused on γδT cells -cells that act as a bridge between the innate and adaptive arm of the immune system- in cancer immunotherapy.

Does electroacupuncture benefit mixed urinary incontinence? A systematic review and meta-analysis with trial sequential analysis.

Introductin And Hypothesis: Mixed urinary incontinence (MUI) comprises a combination of urgency and stress. The efficacy and safety of electroacupuncture (EA) for the treatment of MUI remain unclear.

Objective: To assess the efficacy and safety of EA in treating MUI.

[Progress of researches on mechanisms of acupuncture in treatment of Parkinson's disease].

Parkinson's disease (PD) is a common neurodegenerative disease, and acupuncture has shown potential advantages in the treatment. By analyzing the experimental researches on acupuncture therapy of PD over the past 10 years, the authors find that acupuncture can play a therapeutic role by regulating multiple targets such as basal ganglia neurotransmitter disorder, oxidative stress, abnormal protein folding, immune inflammatory response, apoptosis, neural stem cells and calcium homeostasis. Although the mechanism of acupuncture in the treatment of PD is widely studied, there is still a lack of systematic, in-depth and high-quality research, and the mechanism of acupuncture therapy has not reached a consensus.

[Network Meta-analysis of acupuncture and moxibustion for allergic rhinitis].

Objective: To review the therapeutic effect of acupuncture and moxibustion on allergic rhinitis based on the network Meta-analysis.

Methods: The randomized controlled trials of acupuncture and moxibustion for allergic rhinitis were retrieved from the databases, starting from the date of establishment to August 17, 2020, i.e.

Development and Application of Medicine-Engineering Integration in the Rehabilitation of Traumatic Brain Injury.

The rapid progress of the combination of medicine and engineering provides better chances for the clinical treatment and healthcare engineering. Traumatic brain injury (TBI) and its related symptoms have become a major global health problem. At present, these techniques has been widely used in the rehabilitation of TBI.

[Research progress in the integration of machine learning and acupunctology].

Machine learning is a newly emerged discipline. It develops rapidly and has been penetrated into all walks of life and made great achievements in medical field. The introduction of machine learning in the field of acupuncture and moxibustion should fully play the advantages of targeted therapy of acupuncture and moxibustion, optimize the resource allocation of traditional Chinese medicine and accurately serve the clinic rather than only limited to data mining and analysis.

Jia-Ji Electro-Acupuncture Improves Locomotor Function With Spinal Cord Injury by Regulation of Autophagy Flux and Inhibition of Necroptosis.

Jia-Ji electro-acupuncture (EA) has been widely applied in clinic to exhibit curative effects on spinal cord injury (SCI). However, its underlying mechanisms leading to improvement of motor function after SCI remain unclear. Allen's method was made by NYU Impactor M-III equipment to create the SCI rats model.

Risk factors of postoperative low back pain for low-grade isthmic spondylolisthesis: a retrospective study.

Objective: To investigate the risk factors of postoperative low back pain (LBP) following posterior lumbar interbody fusion (PLIF) surgery for low-grade isthmic spondylolisthesis (IS).

Methods: This retrospective study enrolled patients with IS that underwent PLIF between January 2011 and January 2016. Demographic, clinical, surgical and radiological characteristics were analysed to determine associations between these characteristics and LBP as measured using a visual analogue scale (VAS) pain score.