Three Prognostic Biomarkers Correlate with Immune Checkpoint Blockade Response in Bladder Urothelial Carcinoma.

Aim: We aim to develop a signature that could accurately predict prognosis and evaluate the response to immune checkpoint blockade (ICB) in bladder urothelial carcinoma (BLCA).

Methods: Based on comprehensive analysis of public database, we identified prognosis-related hub genes and investigated their predictive values for the ICB response in BLCA.

Results: Among 69 common DEGs, three genes (AURKA, BIRC5, and CKS1B) were associated with poor prognosis, and which were related to histological subtypes, TP53 mutation status, and the C2 (IFN-gamma dominant) subtype.

[Prediction on spatial migration of suitable distribution of Elaeagnus mollis under climate change conditions in Shanxi Province, China].

The impacts of climate change on biodiversity and its adaptation will directly affect the efficiency of biodiversity conservation. Predicting spatial variation of suitable habitats of threatened species under future climate change has important theoretical and practical significance for biodiversity conservation. In this study, we predicted the suitable distribution of Elaeagnus mollis, an endemic endangered plant in China, under climate change at regional scales.

[Prediction of the suitable distribution and responses to climate change of Elaeagnus mollis in Shanxi Province, China].

Understanding the responses of the habitats of endangered species to climate change is of great significance for biodiversity conservation and the maintenance of the integrity of ecosystem function. In this study, the potential suitable distribution habitats of Elaeagnus mollis in Shanxi Province was simulated by the maximum entropy model, based on 73 occurrence field records and 35 environmental factors under the current climate condition. Moreover, with the Fifth Assessment Report of Intergovernmental Panel on Climate Change, the dynamics of distribution pattern was analyzed for E.

Protective effects of IL-4 on Bacillus Calmette-Guerin and lipopolysaccharide induced immunological liver injury in mice.

Objective: Mice injected with Bacillus Calmette-Guérin (BCG) were challenged with lipopolysaccharide (LPS) to induce inflammatory liver injury. This study was performed to explore the protective effects of interleukin (IL)-4 against liver injury induced by BCG and LPS in mice.

Materials And Methods: Mice injected with BCG (125 mg/kg) were challenged with LPS (10 μg/kg) to induce the model of inflammatory liver injury.