Pesticides and antibiotics have been frequently reported in the environment, but it remains unclear whether antibiotics affect the toxicity of pesticides to aquatic organisms. In this study, the acute, developmental and reproductive toxicity effects of the pesticide chlorantraniliprole on zebrafish at different developmental stages under pressure of ciprofloxacin and erythromycin at environmental concentration were explored. Chlorantraniliprole, ciprofloxacin, and erythromycin are all low toxic to zebrafish (LC > 100 mg/L), and environmental concentrations of antibiotics have no effect on the acute toxicity of chlorantraniliprole to zebrafish.
View Article and Find Full Text PDFThe reproductive and transgenerational effects of malathion, a widely utilized low-toxicity organophosphorus insecticide, were explored using zebrafish as model animal. Adult zebrafish (F0) were exposed to malathion at 0.1-1.
View Article and Find Full Text PDFThe bioaccumulation, metabolism, tissue-specific distribution and toxicity of the widely used organophosphorous pesticide malathion to zebrafish were investigated on an enantiomeric level for evaluating the environmental risks. The metabolites were also monitored and evaluated. Malathion was metabolized by zebrafish very fast with the half-life of 0.
View Article and Find Full Text PDFThere is a growing consensus that the appropriate microbiome abundant environment actuates microbiota changes to influence human health. Whether living environment reacts on the threat of contaminants and the underlying mechanism remain largely unknown. Therefore, we constructed microbiome abundant environment models, focusing on their regulatory effects on the obesity induced by the exogenous chemical chlorpyrifos (CPF) and the related mechanisms.
View Article and Find Full Text PDFPesticides are widely used and frequently detected in the environment. The evaluation on the toxic effects of the co-exposure of two or more pesticides or related metabolites could reflect the real situation of the exposing risks. In this study, zebrafish was used as a model to investigate the potential toxic interactions of chlorpyrifos and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on the survival rate, oxidative stress response and neurotoxicity, as well as their bioaccumulation and distribution in tissues.
View Article and Find Full Text PDFSurfactants and pesticides can be simultaneously detected in the environment by the reason of their widespread use and large amounts of emissions. Due to the special amphipathicity of surfactants, it may have special effects on the environmental behaviors and toxic effects of other substances in the environment. There are few relevant studies at present.
View Article and Find Full Text PDFPyriproxyfen is a juvenile hormone analogue insecticide used worldwide. At present, the potential threat of pyriproxyfen to aquatic organism has not been well explored. In this work, the bioaccumulation, metabolic profile and toxicity of pyriproxyfen and its metabolites to zebrafish were studied, and the enantioselectivity of pyriproxyfen and the major chiral metabolites were also determined.
View Article and Find Full Text PDFChiral fungicide prothioconazole has a wide range of antifungal spectrum; however, little research has been conducted to evaluate prothioconazole on an enantiomeric level. Five target pathogens and three common aquatic organisms were tested for the enantioselective bioactivity and toxicity of prothioconazole in this work. The antifungal activity of the enantiomers against wheat phytoalexin, rice blast fungus, exserohilum turcicum, Alternaria triticina, and Fusarium avenaceum was determined, and it was found that (-)-prothioconazole were 85 to 2768 times more active than (+)-prothioconazole toward these target organisms.
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