Publications by authors named "Yimou Du"
Background: Aspergillus niger is an important industrial filamentous fungus used to produce organic acids and enzymes. A wide dynamic range of promoters, particularly strong promoters, are required for fine-tuning the regulation of gene expression to balance metabolic flux and achieve the high yields of desired products. However, the limited understanding of promoter architectures and activities restricts the efficient transcription regulation of targets in strain engineering in A.
View Article and Find Full Text PDFGenome-wide transcription landscape of citric acid producing in response to glucose gradient.
Front Bioeng Biotechnol
October 2023
Article Synopsis
- * Researchers analyzed genome-wide changes in gene expression when the fungus was exposed to different glucose concentrations, revealing significant transcriptional reprogramming in genes related to cellular functions like ribosome production and glucose transport.
- * Findings indicate that certain glucose transporters' expression levels adapt based on glucose availability, which significantly influences citric acid production, providing insights into the fungus's metabolic responses and evolutionary adaptations.