LCN2 Regulates Microglia Polarization Through the p38MAPK-PGC-1α-PPARγ Pathway to Alleviate Traumatic Brain Injury.

Traumatic brain injury (TBI) is a common traumatic event that imposes a significant burden on families and society. Lipocalin (LCN) is a class of multifunctional secreted lipoprotein molecules. This study aimed to explore the role and possible mechanism of LCN2 in TBI.

Sustainable production of organic acids from chitin biomass catalyzed by Keggin-type heteropolyacid under hydrothermal condition.

The "shell biorefinery," which valorizes the shell waste chitin into fine chemicals, has developed rapidly in recent years. Herein, we present a novel base-free heteropolyacid-catalyzed oxidation method for the transformation of chitin biomass into organic acid. After a series of optimization experiments, a 5.

Exploration of Lasmiditan 200 mg Versus 100 mg for the Treatment of Migraine: A Meta-analysis Based on Aggregate Data.

Objectives: Lasmiditan holds important potential in treating migraine, but its ideal dose remains elusive. This meta-analysis is conducted based on aggregate data and aims to compare the efficacy of lasmiditan 200 mg versus 100 mg for acute treatment of migraine attack.

Methods: PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases were systematically searched, and we included the randomized controlled trials comparing the efficacy of lasmiditan 200 mg versus 100 mg for migraine patients.

Direct conversion of chitin derived N-acetyl-D-glucosamine into 3-acetamido-5-acetylfuran in deep eutectic solvents.

3-Acetylamino-5-acetylfuran (3A5AF) is an important nitrogen-containing fine chemical with broad application prospects and high research value. Herein, we report a novel method for the conversion of N-acetyl-d-glucosamine (NAG) to 3A5AF in the choline chloride-based deep eutectic solvents (DESs). The catalytic activities of various DESs have been smoothly screened, and DES 2 (choline chloride/PEG-200/boronic acid = 1/1/0.

The Efficacy and Safety of Adjuvant Lomustine to Chemotherapy for Recurrent Glioblastoma: A Meta-analysis of Randomized Controlled Studies.

Introduction: Lomustine is regarded as 1 common anti-vascular endothelial growth factor agent. The efficacy of adjuvant lomustine to chemotherapy remains controversial for recurrent glioblastoma. We conduct this meta-analysis to explore the influence of adjuvant lomustine on treatment efficacy of recurrent glioblastoma.

Valorization of chitin biomass into N-containing chemical 3-acetamido-5-acetylfuran catalyzed by simple Lewis acid.

3-Acetamido-5-acetylfuran(3A5AF) is a nitrogen-containing fine chemical and has broad application prospects and high research value. Herein, we report a mild and efficient method for the synthesis of 3A5AF from N-acetyl-d-glucosamine (NAG). The influence of solvent, temperature and additive on the catalytic performance was also studied.

Tranexamic acid for subarachnoid hemorrhage: A systematic review and meta-analysis.

Background: The efficacy of tranexamic acid for subarachnoid hemorrhage remains controversial. Thus, we conduct this meta-analysis to explore the efficacy of tranexamic acid for subarachnoid hemorrhage.

Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched.

Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation.

Glioblastoma (GBM) is a deadly brain tumor with a bleak prognosis. In recent years, the copine III (CPNE3) protein was discovered to be associated to metastasis across various types of malignancies. Nevertheless, its function has not been well documented in glioma.

The efficacy and safety of radiotherapy with adjuvant temozolomide for glioblastoma: A meta-analysis of randomized controlled studies.

The efficacy of radiotherapy with adjuvant temozolomide for glioblastoma remains controversial. We conduct a systematic review and meta-analysis to explore the influence of radiotherapy with adjuvant temozolomide on treatment efficacy for glioblastoma.We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 24, 2019 for randomized controlled trials (RCTs) assessing the efficacy and safety of adjuvant temozolomide to radiotherapy for glioblastoma.