Publications by authors named "Yiming Lu"

Sepsis, a condition of significant clinical concern, is characterized by life-threatening organ dysfunction that arises from an infection and is exacerbated by a dysregulated host response. Targeting immune modulation, particularly against tumor necrosis factor-alpha (TNF-α), has emerged as a promising anti-inflammatory therapeutic strategy. However, approaches such as blood purification to eliminate inflammatory mediators or the use of anti-TNF-α therapies have shown limited efficacy in clinical practice.

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To identify genomic regions subject to positive selection that might contain genes involved in high-altitude adaptation (HAA), we performed a genome-wide scan by whole-genome sequencing of Tibetan highlanders and Han lowlanders. We revealed a collection of candidate genes located in 30 genomic loci under positive selection. Among them, MCUR1 at 6p23 was a novel pronounced candidate.

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Introduction: Smoking is associated with significant alterations in sleep architecture. Previous studies have revealed changes in the subjective sleep of young smokers, but research on objective sleep assessment using polysomnography (PSG) is limited. This study aims to explore electroencephalography (EEG) power and sleep spindle activity during the sleep of young smokers, as well as to assess the relationship between sleep and smoking variables.

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Background: Aphids are significant agricultural pests, causing extensive crop damage and transmitting plant viruses. Conventional insecticide-based pest control faces challenges such as human and environmental toxicity and resistance. As alternative solutions, pheromone-based repellents have emerged as a promising approach.

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This review seeks to elucidate the therapeutic potential of tumor necrosis factor receptor 1 (TNFR1) and enhance our comprehension of its role in disease mechanisms. As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK), which are associated with pro-inflammatory responses and cell death. The intricate regulatory mechanisms of TNFR1 signaling and its involvement in various diseases, including inflammatory disorders, infectious diseases, cancer, and metabolic syndromes, have attracted increasing scholarly attention.

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Iron deficiency is prevalent among pregnant women because of the increased maternal iron requirements. Uncorrected maternal iron deficiency can lead to adverse neurodevelopmental outcomes in neonates. Therefore, the aim of this study was to assess serum ferritin concentration and prevalence of iron deficiency among pregnant women in Jiangsu, China.

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Birds use their claws to perch on branches, which helps them to recover energy and observe their surroundings; however, most biomimetic flapping-wing aircraft can only fly, not perch. This study was conducted on the basis of bionic principles to replicate birds' claw and wing movements in order to design a highly biomimetic flapping-wing aircraft capable of perching. First, a posture conversion module with a multi-motor hemispherical gear structure allows the aircraft to flap, twist, swing, and transition between its folded and unfolded states.

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Purpose: The completely degloving injury of multiple fingers is a challenging clinical problem. Based on our technical experience, a novel two-stage surgery of abdominal hypodermal pocket followed by separation and full thickness skin grafting was conducted.

Methods: From January 2017 to August 2020, 7 cases (17 fingers) of degloving injury of multiple whole fingers who were treated in a two-stage fashion; an emergency first stage surgery of abdominal hypodermal pocket embedding and a second stage surgery (4 weeks later) of full thickness skin grafting, were retrospectively studied.

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  • - The Chinese government aims to boost the five-year cancer survival rate by 15% by 2030, emphasizing the need for better medical knowledge and public awareness about cancer prevention and treatment.
  • - A survey conducted from January to May 2023 collected responses from 2,711 participants across various groups, indicating that many medical professionals and the public are engaged in learning about cancer health, but face significant challenges such as time constraints and misinformation.
  • - While there is a strong interest in cancer education among both healthcare providers and the public, there is a pressing need for improved quality and accuracy of information in cancer prevention and treatment resources.
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  • Targeted immunotherapies improve cancer treatment by countering tumors' ability to suppress the immune system, leveraging advanced biomimetic technologies for precise drug delivery.
  • * The use of dendritic cell (DC) membranes on nanoparticles enhances immune activation by targeting tumor environments and activating T cells effectively.
  • * This review discusses the methods for creating DC membranes, their applications in cancer therapy, and how they could enhance treatment outcomes when combined with other therapies like chemotherapy and photodynamic treatments.
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  • * A compound based on the 1,2,4-oxadiazole structure demonstrated strong antifungal properties against rice sheath blight disease in both lab tests and real-world situations, indicating its effectiveness.
  • * Further optimizations of these 1,2,4-oxadiazole compounds led to new analogues that significantly improved control of rice blast disease, highlighting their potential as promising antifungal agents in pesticide development.
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  • Online platforms share scientific facts about risks and influence audience emotions by structuring narratives around past, present, and future events.
  • A study of 210 TED talks from 2002 to 2018 shows that focusing on the past evokes negative emotions, the present evokes less positive emotions, and the future promotes more positive feelings.
  • Using concrete examples in these narratives enhances audience awareness and emotional responses, highlighting how focusing on time can help manage reactions to risks.
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Cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths every year. Immune checkpoint blockade approaches have changed the therapeutic landscape for many tumor types. However, current immune checkpoint inhibitors PD-1 or CTLA-4 are far from satisfactory, due to high immune-related adverse event incident (up to 60%) and the inefficiency in cases of "cold" tumor microenvironment.

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  • Electron spin qubits are gaining attention in quantum computing, but their development is hampered by quantum decoherence, leading to short coherence times.
  • Few qubits operate at room temperature, but studies suggest that radicals may be ideal candidates due to their longer coherence times.
  • The research highlights a photogenerated radical based on tpt, which exhibits a remarkable coherence time of 1.1 μs at temperatures above 20 K and can maintain stability at room temperature, with enhancements observed in tpt films created through vacuum evaporation.
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  • - The text discusses the issue of cellular senescence, where aging cells accumulate in tissues, hindering the body's ability to heal and regenerate after injury.
  • - Recent research highlights that clearing these senescent cells and improving the tissue environment using biomaterials can enhance the body's regenerative capabilities.
  • - The review aims to shed light on the characteristics of senescent cells and their impact on tissue repair, ultimately suggesting a combined approach of targeting cellular senescence and utilizing biomaterials for better regenerative medicine strategies.
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  • * The protein Trf2, which protects telomeres, is shown to decrease in mice experiencing post-hypoxic stress, and lowering its expression in healthy brain cells can mimic excitotoxic symptoms.
  • * Conversely, boosting Trf2 levels can mitigate brain damage and oxidative stress related to glutamate in neurons, suggesting that enhancing Trf2 expression might help reduce damage after hypoxic events.
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  • Reactive astrogliosis is a key factor in secondary spinal cord injuries and biomaterials can inhibit astrocyte activation, but the underlying mechanisms are not fully understood.
  • The study identifies the VIM gene as a crucial regulator in reactive astrocytes using whole transcriptome sequencing on a mouse spinal cord injury model, highlighting the role of differentially expressed genes (DEGs) in the extracellular matrix (ECM).
  • The research demonstrates that 3D injectable electrospun fibers effectively reduce reactive astrogliosis by downregulating the VIM gene and disrupting the NF-κB signaling pathway, thus promoting recovery of spinal cord function by preventing further inflammation and neuronal apoptosis.
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  • Immune-related adverse events, especially colitis, hinder the progress of immune checkpoint therapies, leading researchers to explore strategies like blocking TNF-α and modifying gut microbiota.
  • A mouse model demonstrated that combining Infliximab with DICB reduced colitis and improved therapeutic effectiveness, while also revealing changes in gut microbiota linked to the condition.
  • The study indicates that a complex feedback loop involving DICB, TNF-α, and gut microbiota plays a crucial role in irAE-colitis, with Infliximab showing promise in treating its toxicity.
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Sentrin/small ubiquitin-like modifier (SUMO)-specific proteases (SENPs) perform pivotal roles in SUMO maturation and recycling, which modulate the balance of SUMOylation/de-SUMOylation and spatiotemporal functions of SUMOylation targets. The malfunction of SENPs often results in cellular dysfunction and various diseases. However, studies rarely investigated the correlation between SENP2 and lung cancer.

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  • Strokes are really dangerous, especially for older people, and they can lead to serious problems or even death.
  • Doctors usually use CT and MRI scans to find strokes, but these scans can take a long time and are expensive, making it hard to detect strokes quickly.
  • A new computer program (an AI model) was made to look at 2D pictures of people's faces to find out if they might have had a stroke, helping doctors give faster care before doing more tests.
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Background: Whiteflies are major pests in agriculture, causing damage to crops and transmitting plant viruses. Using Volatile Organic Compounds (VOCs) as semiochemicals offers a sustainable approach for combating whiteflies. One such group of compounds, represented by β-ionone, has been found to possess repellent/attractant properties.

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Purpose: To investigate the clinical effect of posterior perforator tibial artery flaps on repairing soft tissue defects of limbs.

Methods: From June 2012 to June 2021, 14 cases of soft tissue defects of limbs were repaired with pedicled or free flaps of posterior perforator tibial artery. Among them, there were 9 cases of pedicled flaps and 5 cases of free flaps.

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Background: Gastric signet ring cell carcinoma (GSRCC) is a rare and highly malignant disease with a poor prognosis. To assess the overall survival (OS) and cancer-specific survival (CSS) of patients with GSRCC, prognostic nomograms were developed and validated using common clinical factors.

Methods: This retrospective cohort study included patients diagnosed with GSRCC between 2011 and 2018 from the National Cancer Center (n = 1453) and SEER databases (n = 2745).

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  • Lung cancer is often diagnosed too late, making it harder to treat and more dangerous.
  • Scientists found that certain tiny bacteria's DNA in the blood can help detect lung cancer earlier and predict if it might come back after treatment.
  • A new method they created is really good at spotting early-stage lung cancer, with a success rate of around 87%, which could improve survival chances.
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Most recurrences of lung cancer (LC) occur within 3 years after surgery, but the underlying mechanism remains unclear. Here, we collect LC tissues with shorter (<3 years, recurrence group) and longer (>3 years, non-recurrence group) recurrence-free survival. By using 16S sequencing, we find that intratumor microbiome diversity is lower in the recurrence group and butyrate-producing bacteria are enriched in the recurrence group.

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