Rhoptry proteins affect the placental barrier in the context of Toxoplasma gondii infection: Signaling pathways and functions.

Toxoplasma gondii is an opportunistic and pathogenic obligate intracellular parasitic protozoan that is widespread worldwide and can infect most warm-blooded animals, seriously endangering human health and affecting livestock production. Toxoplasmosis caused by T. gondii infection has different clinical manifestations, which are mainly determined by the virulence of T.

The Role of Metabolomics and Microbiology in Urinary Tract Infection.

One of the common illnesses that affect women's physical and mental health is urinary tract infection (UTI). The disappointing results of empirical anti-infective treatment and the lengthy time required for urine bacterial culture are two issues. Antibiotic misuse is common, especially in females who experience recurrent UTI (rUTI).

Preparation of Budesonide-Loaded Liposomal Nanoparticles for Pulmonary Delivery and Their Therapeutic Effect in OVA-Induced Asthma in Mice.

Purpose: Inhaled corticosteroids, including budesonide (BUD), are widely employed for the treatment of asthma. However, the frequent use of corticosteroids is associated with numerous adverse effects and poses challenges to ongoing drug therapy and patient adherence. Budesonide liposomal nanoparticles (BUD-LNPs) were developed to improve the bioavailability of the drug and thereby improve the effectiveness of asthma treatment.

Toxoplasma rhoptry proteins that affect encephalitis outcome.

Toxoplasma gondii, a widespread obligate intracellular parasite, can infect almost all warm-blooded animals, including humans. The cellular barrier of the central nervous system (CNS) is generally able to protect the brain parenchyma from infectious damage. However, T.

Integration of gut microbiome and serum metabolome revealed the effect of Qing-Wei-Zhi-Tong Micro-pills on gastric ulcer in rats.

Ethnopharmacological Relevance: Qing-Wei-Zhi-Tong Micro-pills (QWZT) is herbal compound used in the treatment of GU, whose functions include clearing the stomach and fire, softening the liver and relieving pain. However, its mechanistic profile on host intestinal microbiota and metabolism has not been determined.

Aim Of The Study: The present study aimed to observe the healing effect of QWZT on acetic acid-induced gastric ulcer in a rat model and to preliminarily elucidate its possible therapeutic mechanism from the perspective of host intestinal microbiota and metabolism.

Efferocytosis and Respiratory Disease.

Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis.

Corrosion protection properties of tetraphenylethylene-based inhibitors toward carbon steel in acidic medium.

Four novel corrosion inhibitors (1, 2, 3 and 4) integrating different tetraphenylethylene (TPE) cations and thiocyanate (SCN) anions were developed. Weight-loss and electrochemical measurements were employed to assess their protective properties toward carbon steel in 0.5 M HSO, revealing them as effective corrosion inhibitors in the order of 3 > 4 > 2 > 1, with the inhibition efficiencies of 2, 3 and 4 all exceeding 97%.

FTO mediates LINE1 mA demethylation and chromatin regulation in mESCs and mouse development.

-methyladenosine (mA) is the most abundant internal modification on mammalian messenger RNA. It is installed by a writer complex and can be reversed by erasers such as the fat mass and obesity-associated protein FTO. Despite extensive research, the primary physiological substrates of FTO in mammalian tissues and development remain elusive.

Anomalous Photoinduced Reconstructing and Dark Self-Healing Processes on BiOS Nanoplates.

We report an anomalous photoinduced reconstructing and dark self-healing process on BiOS nanoplates by monitoring the time profile of open-circuit potential (OCP). When the light was switched on and off on the nanoplates, we observed pronounced and repeatable decrement-recovery cycles of the OCP signal, which are inexplicable by a rapid electron-hole separation-recombination process only as in a conventional semiconductor. It is proposed that upon irradiation, accumulation of photogenerated holes at the electrode surface caused oxidation of the S layers of BiOS nanoplates into certain intermediates, which, when the light was turned off, were then reduced back to the original state by the electron back flow.

In situ growth of FeWO on WO nanosheets to fabricate heterojunction arrays for boosting solar water splitting.

We demonstrate the construction of heterojunction arrays for boosting solar water splitting by combining in situ guided growth of heterointerfaces and energy band tuning. By directly growing an ultrathin FeWO layer on a preformed WO nanosheet array in full coverage, a uniform and dense array of intimately contacted WO/FeWO heterojunction was created. The heterojunction array shows not only a largely broadened visible light absorption range but also a built-in interface polarization to accelerate hole transfer from WO to FeWO.

From One to Two: In Situ Construction of an Ultrathin 2D-2D Closely Bonded Heterojunction from a Single-Phase Monolayer Nanosheet.

Despite the many attempts to build ultrathin 2D-2D heterojunctions via wet chemical methods, the resulting composite materials reported to date suffer from poor interfacial bonding and/or complexity of the synthetic protocols. Encouraged by the structural compatibility of BiWO and BiOS, both of which are 2D semiconductors sharing a rather similar structural unit of a [BiO] slice in their crystal structures, we have successfully fabricated an ultrathin nanosheet with a tightly bonded 2D-2D heterojunction between the two components by facilely joining the [BiO] and [S] slices using a simple two-step hydrothermal method. Such a BiWO-BiOS 2D-2D heterojunction has a five-alternating-layer (BiOS-BiWO-BiOS-BiWO-BiOS) sandwich structure and a thickness down to ca.

Three-Dimensional Decoupling Co-Catalyst from a Photoabsorbing Semiconductor as a New Strategy To Boost Photoelectrochemical Water Splitting.

A cocatalyst is normally deposited on a photoabsorbing semiconductor (PAS) for photoelectrochemical (PEC) water splitting, but with drawbacks of limited loading, reduced light absorption, and tendency of charge recombination. To tackle these problems, a scheme of three-dimensional (3D) decoupling cocatalysts from the PAS with a pore-spanning crisscross conducting polymer host is proposed in this work. To demonstrate the concept, a facile method was developed for the in situ cogrowth of FeO nanoparticles and conducting polymer (CP) network in various PAS with different microstructures such as a TiO nanorod array, WO nanosheet array, and planar TiO nanoparticle film, generating the bespoke photoanodes.

Exploratory Study of Zn PbO Photoelectrodes for Unassisted Overall Solar Water Splitting.

A complete photoelectrochemical (PEC) water splitting system requires a photocathode and a photoanode to host water oxidation and reduction reactions, respectively. It is thus important to search for efficient photoelectrodes capable of full water splitting. Herein, we report on an exploratory study of a new photoelectrode family of Zn PbO -ZnPbO and ZnPbO-similarly synthesized by a simple and economical method and shown to be a promising photocathode (p-type semiconductor) and photoanode (n-type semiconductor), respectively.

Constructing three-dimensional porous Ni/NiS nano-interfaces for hydrogen evolution electrocatalysis under alkaline conditions.

It is still a challenging issue to design earth-abundant electrocatalysts with low cost, high activity and long-term stability for the hydrogen evolution reaction (HER) based on water splitting in alkaline solutions. Here, we report a facile synthetic route for a three-dimensional, porous Ni/NiS nano-network on carbon cloth for the efficient catalysis of HER. This unique structure exposes a high proportion of Ni/NiS hetero-interfaces to the electrolyte, creating a synergetic effect between Ni and NiS that enhances HER.

Co(II)1-xCo(0)x/3Mn(III)2x/3S Nanoparticles Supported on B/N-Codoped Mesoporous Nanocarbon as a Bifunctional Electrocatalyst of Oxygen Reduction/Evolution for High-Performance Zinc-Air Batteries.

Rechargeable Zn-air battery is an ideal type of energy storage device due to its high energy and power density, high safety, and economic viability. Its large-scale application rests upon the availability of active, durable, low-cost electrocatalysts for the oxygen reduction reaction (ORR) in the discharge process and oxygen evolution reaction (OER) in the charge process. Herein we developed a novel ORR/OER bifunctional electrocatalyst for rechargeable Zn-air batteries based on the codoping and hybridization strategies.