Preclinical evaluation and first-in-human study of [F]AlF-FAP-NUR for PET imaging cancer-associated fibroblasts.

Background: Fibroblast activation protein (FAP) has gained attention as a promising molecular target with potential utility for cancer diagnosis and therapy. [Ga]Ga-labeled FAP-targeting peptides have been successfully applied to positron emission tomography (PET) imaging of various tumor types. To meet the applicable demand for peptide-based FAP tracers with high patient throughput, we herein report the radiosynthesis, preclinical evaluation, and the first-in-human imaging of a novel [F]F-labeled FAP-targeting peptide.

Water use efficiency in China is impacted by climate change and land use and land cover.

A crucial physiological indicator known as water use efficiency (WUE) (Foley et al.) assesses the trade-off between water loss and carbon uptake. The carbon and water coupling mechanisms, energy balance, and hydrological cycle processes in the ecosystem are impacted by climate change, vegetation dynamics, and land use change.

The diagnostic value of [F]FAPI-42 PET/CT for pulmonary artery masses: comparison with [F]FDG PET/CT.

Objectives: To investigate the potential utility of [F]fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) for evaluating pulmonary artery (PA) masses, and compare it with [F]fluorodeoxyglucose (FDG) PET/CT.

Methods: Participants with clinically suspected PA malignancy were prospectively enrolled and underwent dual-tracer PET/CT ([F]FAPI-42 and [F]FDG) imaging. Visual analysis and semi-quantitative parameters were compared between the two types of radiotracers.

PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway.

Background: Mitochondrial dysregulation in skeletal myocytes is considered a major factor in aged sarcopenia. In this study, we aimed to study the effects of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) on Sestrin2-mediated mechanistic target of rapamycin complex 1 (mTORC1) in aged skeletal muscles.

Methods: C2C12 myoblasts were stimulated by 50 μM 7β-hydroxycholesterol (7β-OHC) to observe the changes of DNA damage, mitochondrial membrane potential (Δψm), mitochondrial ROS and PGC-1α protein.

Orientational Distribution Learning With Hierarchical Spatial Attention for Open Set Recognition.

Open set recognition (OSR) aims to correctly recognize the known classes and reject the unknown classes for increasing the reliability of the recognition system. The distance-based loss is often employed in deep neural networks-based OSR methods to constrain the latent representation of known classes. However, the optimization is usually conducted using the nondirectional euclidean distance in a single feature space without considering the potential impact of spatial distribution.

Black corn (Zea mays L.) soluble extract showed anti-inflammatory effects and improved the intestinal barrier integrity in vivo (Gallus gallus).

Black corn (Zea mays L.) is a pigmented type of this cereal whose color of the kernels is attributed to the presence of the anthocyanins. In this study, we assessed the black corn soluble extract (BCSE) effects on the intestinal functionality, morphology, and microbiota composition using an in vivo model (Gallus gallus) by an intra-amniotic administration.

LncRNA RP5-857K21.7 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells through the miR-508-3p/PI3K/AKT/mTOR axis.

The continuous increase in the prevalence of asthma poses a threat to human health. Despites numerous researches, the understanding of asthma development still remain elusive, hindering the development of effective treatment. Here, we explored the role of lncRNA RP5-857K21.

From State-controlled to Polycentric Governance in Forest Landscape Restoration: The Case of the Ecological Forest Purchase Program in Yong'an Municipality of China.

Forest landscape restoration is emerging as an effective approach to restore degraded forests for the provision of ecosystem services and to minimize trade-offs between conservation and rural livelihoods. Policy and institutional innovations in China illustrate the governance transformation of forest landscape restoration from state-controlled to polycentric governance. Based on a case study of the Ecological Forest Purchase Program in Yong'an municipality, China's Fujian Province, this paper explores how such forest governance transformation has evolved and how it has shaped the outcomes of forest landscape restoration in terms of multi-dimensionality and actor configurations.

Effects of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis.

Background: Olmesartan is a type of angiotensin II receptor inhibitor that can reduce the incidence of cardiovascular events. However, its role in the function of endothelial progenitor cells in atherosclerosis patients is still unclear. Our study aimed to explore the effects and mechanism of olmesartan on endothelial progenitor cell mobilization and function in carotid atherosclerosis.