A Luminescent Cd-MOF Used as a Chemosensor for High-Efficiency Sensing of Fe, Cr(IV), Trinitrophenol, and Colchicine.

A Cd-MOF was constructed based on 3,5-bis(4-carboxyphenyl) pyridine under solvothermal conditions. Its structure and phase purity were verified by single-crystal X-ray diffraction. Thereafter, some studies on the morphology, structure, and luminescent properties of the compound were carried out.

LncRNA DGUOK-AS1 facilitates non-small cell lung cancer growth and metastasis through increasing TRPM7 stability via m6A modification.

Background: N6-methyladenosine (m6A) modification plays key roles in tumor progression. LncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) has been reported as a promoter in tumors, but its role and mechanism in non-small cell lung cancer (NSCLC) development remain uncertain.

Methods: Cell proliferation, migration, invasion and angiogenesis were investigated via CCK-8, colony formation, transwell, and tube formation assays, respectively.

A Water-Stable Zn-MOF Used as Multiresponsive Luminescent Probe for Sensing Fe/Cu, Trinitrophenol and Colchicine in Aqueous Medium.

A water-stable Zn-MOF was constructed based on HPBA and 1, 10-phenanthroline under solvothermal conditions. The compound exhibited a 3D (2,3,8)-connected (4)(4.6.

IL-35 enhances angiogenic effects of small extracellular vesicles in breast cancer.

As an indispensable process for breast cancer metastasis, tumour angiogenesis requires a tight interaction between cancer cells and endothelial cells in tumour microenvironment. Here, we explored the participation of small extracellular vesicles (sEVs) derived from breast cancer cells in modulating angiogenesis and investigated the effect of IL-35 in facilitating this process. Firstly, we characterized breast cancer cells-derived sEVs untreated or treated with IL-35 and visualized the internalization of these sEVs by human umbilical vein endothelial cells (HUVECs).

Role of extracellular polymeric substances on the behavior and toxicity of silver nanoparticles and ions to green algae Chlorella vulgaris.

The effect of extracellular polymeric substances (EPS), vital organic matters and nutrient elements in the natural environment, on the behavior and toxicology of silver nanoparticles (AgNPs) and ions remains ambiguous. In this study, the role of EPS on the toxicity of AgNPs and dissolved silver ions (from AgNO) to a green algae Chlorella vulgaris was investigated. After the removal of EPS, algae accumulated more silver, about 7.

Correlations of Galectin-3 Gene Polymorphisms with Risk and Prognosis of Cervical Cancer in Chinese Populations: A Case-Control Study.

Background: This study explores correlations of galectin-3 gene polymorphisms (rs4644, rs4652, and rs11125) with cervical cancer risk and prognosis in Chinese populations.

Methods: A total of 126 patients with cervical cancer were selected to form the case group, and 102 healthy people were selected for the control group following a physical examination. 3 polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

The Mechanism of Proinflammatory HDL Generation in Sickle Cell Disease Is Linked to Cell-Free Hemoglobin via Haptoglobin.

In sickle cell disease (SCD), the inflammatory properties of high-density lipoprotein (HDL) can be changed by cell-free hemoglobin (Hb), which is released into the blood during hemolysis. Hb in the plasma of SCD patients or mice can bind with HDL specifically inducing an inflammatory reaction. In our study, we found increased amounts of inflammatory factor proteins in the chronic oxidative state of SCD with higher levels of Hb, haptoglobin (Hp) and hemopexin (Hx) in the apolipoprotein A-I (ApoA-1) particles of HDL and the role of HDL is changed from being anti-inflammatory to proinflammatory.

Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.

Aim: This study investigated P21-activated kinase 1 (PAK1) and cell division control protein 42 homolog (CDC42) expression and their correlation with clinicopathological features and prognosis in cervical carcinoma.

Methods: Cervical carcinoma (n = 55), cervical intraepithelial neoplasias (CIN, n = 93), and normal cervix (n = 26) tissues were sampled. PAK1 and CDC42 expressions were determined using real-time quantitative polymerase chain reaction, Western blot and immunohistochemistry.

β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Protein.

Recent studies reveal that multifunctional protein β-arrestin 2 (Arrb2) modulates cell apoptosis. Survival and various aspects of liver injury were investigated in WT and Arrb2 KO mice after bile duct ligation (BDL). We found that deficiency of Arrb2 enhances survival and attenuates hepatic injury and fibrosis.

Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6.

Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects including immunosuppression. However, the mechanisms are unclear. TLRs and acetylcholine are widely expressed in the immune and nervous systems, and play critical roles in immune responses.

β-arrestin2/miR-155/GSK3β regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes.

Stem-cell antigen 1-positive (Sca-1+) cardiac stem cells (CSCs), a vital kind of CSCs in humans, promote cardiac repair in vivo and can differentiate to cardiomyocytes with 5'-azacytizine treatment in vitro. However, the underlying molecular mechanisms are unknown. β-arrestin2 is an important scaffold protein and highly expressed in the heart.

FoxM1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370.

Unlabelled: Helicobacter pylori (H. pylori) infections are strongly implicated in human gastric mucosa-associated diseases. Forkhead box M1 (FoxM1), a key positive regulator of cell proliferation, is overexpressed in gastric cancer.

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients.

Background: Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM patients. Deregulation of microRNAs (miRNAs or miRs) is involved in GBM.

Penta-aqua-bis[4-(2-hydroxy-benzyl-idene-amino)benzene-sulfonato]lead(II).

In the structure of the title compound, [Pb(C(13)H(10)NO(4)S)(2)(H(2)O)(5)], two S-O bonds and one C-N bond have lengths of 1.421 (9), 1.425 (8) and 1.

Hexaaqua-nickel(II) bis-[4-(2-hydroxy-benzyl-ideneamino)benzene-sulfonate].

In the title compound, [Ni(H(2)O)(6)](C((C(13) )H(10)NO(4)S)(2), the nickel(II) atom, lying on a center of symmetry, is six-coordinated by six aqua O-atom donors. The dihedral angle between the two benzene rings is 33.1 (3)°.

4-Amino-2-methyl-quinoline monohydrate.

The crystal structure of the title compound, C(10)H(10)N(2)·H(2)O, is stabilized by inter-molecular O-H⋯N, N-H⋯O and N-H⋯N hydrogen bonds.

2,2'-(1,1'-Azinodiethyl-idyne)diphenol.

In the title mol-ecule, C(16)H(16)N(2)O(2), the C-N bond lengths are 1.295 (5) and 1.300 (5) Å, which suggests that they are double bonds.

N'-[1-(2-Hydroxy-phen-yl)ethyl-idene]benzene-sulfonohydrazide.

In the title compound, C(14)H(14)N(2)O(3)S, the conformation is stabilized by an intra-moleclar O-H⋯N hydrogen bond and the dihedral angle between the aromatic ring planes is 79.55 (18)°. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds lead to [100] chains of mol-ecules.

4-(Diethyl-amino)salicylaldehyde phenyl-sulfonyl-hydrazone.

In the title compound, C(17)H(21)N(3)O(3)S, the dihedral angle between the aromatic ring planes is 84.2 (2)°. The pendant ethyl groups of the -N(C(2)H(5))(2) group are disordered over two sets of positions in a 0.

2-Acetyl-3-methyl-pyrazine phenyl-sulfonyl-hydrazone.

In the title compound, C(13)H(14)N(4)O(2)S, the dihedral angle between the aromatic rings is 55.42 (14)°. In the crystal structure, an N-H⋯O hydrogen bond leads to chains of mol-ecules along [001].

Hexaaqua-cadmium(II) bis-[4-(2-hydroxy-benzyl-ideneamino)benzene-sulfonate] dihydrate.

In the title compound, [Cd(H(2)O)(6)](C(13)H(10)NO(4)S)(2)·2H(2)O, the Cd atom (site symmetry ) adopts a regular octa-hedral coordination and the anion is stabilized by an intra-molecular O-H⋯N hydrogen bond. O-H⋯O hydrogen bonds involving the coordinated and uncoordinated water mol-ecules lead to a three-dimensional network.

Bis[2-acetyl-3-methyl-pyrazine (2-hydroxy-benzo-yl)hydrazonato]zinc(II) monohydrate.

In the title compound, [Zn(C(14)H(13)N(4)O(2))(2)]·H(2)O, the Zn(II) centre is six-coordinated by four N and two O donors of two 2-acetyl-3-methyl-pyrazine (2-hydroxy-benzo-yl)hydrazonate ligands, and forms a distorted octa-hedral structure.

Hexaaqua-cobalt(II) bis-[4-(2-hydroxy-benzyl-ideneamino)-benzene-sulfonate].

In the cation of the title compound, [Co(H(2)O)(6)](C(13)H(10)NO(4)S)(2), the Co atom lies on a centre of symmetry and its coordination geometry is octahedral. The crystal structure is stabilized by water-anion O-H⋯O hydrogen bonds. An intra-molecular O-H⋯N hydrogen bond occurs in the anion.

1-Hydroxymethyl-3,12-dioxa-14-aza-tetracyclo[9.2.1.0.0]tetradecane.

In the title fused-ring compound, C(12)H(13)NO(3), the two five-membered C(3)NO rings both approximate to envelope conformations with C atoms in the flap positions. The OH group of the pendant CH(2)OH unit is disordered over two positions in a 0.528 (5):0.

N'-(3-Ethoxy-2-hydroxybenzylidene)-benzenesulfonohydrazide.

There are two mol-ecules in the asymmetric unit of the title compound, C(15)H(16)N(2)O(4)S, both of which are stabilized by an intra-molecular O-H⋯N hydrogen bond. Inter-molecular N-H⋯O hydrogen bonds lead to [101] chains of mol-ecules in the crystal structure.