Publications by authors named "Yimin Cai"

Toxin-antitoxin (TA) modules are important mediators of persister cell formation in response to environmental stresses. However, the mechanisms through which persistence is controlled remain poorly understood. , a novel probiotic, can enter a persistent state upon exposure to tetracycline stress.

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  • - The study investigates the 17p13.3 genomic locus linked to colorectal cancer (CRC) risk, specifically focusing on the single nucleotide polymorphism (SNP) rs12603526 identified in Asian populations, with the aim of uncovering the causal gene and its regulatory mechanisms.
  • - Researchers conducted large-scale analyses with thousands of participants from Chinese and UK populations to validate associations and used functional experiments to identify a key oncogene that drives CRC cell proliferation, linked to the variant rs526835, which increases CRC risk significantly.
  • - The findings reveal that the rs526835 variant enhances the interaction between a promoter and an enhancer, regulated by the transcription factor JUN, leading to increased expression of the identified oncogene, thereby shedding light on
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Lung carcinoma, predominantly manifested as non-small cell lung cancer (NSCLC), significantly contributes to oncological mortality, underscoring an imperative for novel therapeutic paradigms. Amidst this context, the present investigation delineates the synergistic potentiation of doxorubicin (DOX)-a canonical chemotherapeutic-by Ursodeoxycholic acid (UDCA), a compound with a historical pedigree in hepatobiliary medicine, now repositioned within oncological pharmacotherapy due to its dichotomous cellular modulation-affording cytoprotection to non-malignant epithelia whilst eliciting apoptotic cascades in neoplastic counterparts. This study, through a rigorous methodological framework, elucidates UDCA's capacity to inhibit NSCLC cellular proliferation and induce apoptosis, thereby significantly amplifying DOX's chemotherapeutic efficacy.

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Achieving light-induced manipulation of controlled self-assembly in nanosized structures is essential for developing artificially dynamic smart materials. Herein, we demonstrate an approach using a non-photoresponsive hydrogen-bonded (H-bonded) macrocycle to control the self-assembly and disassembly of nanostructures in response to light. The present system comprises a photoacid (merocyanine, 1-MEH), a pseudorotaxane formed by two H-bonded macrocycles, dipyridinyl acetylene, and zinc ions.

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Microplastics and antibiotics are emerging contaminants in agricultural soil that can have negative effects on crops. However, limited research has been conducted on the effects of the polypropylene (PP) microplastic and sulfamethoxazole (SMX) co-exposure on crops, specifically regarding the impact of PP microplastics on SMX uptake and transport in crops. In this study, hydroponic experiments were carried out using lettuce (Lactuca sativa L.

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  • The hippocampus is important for various neuropsychiatric traits, and understanding its subfields' genetic relationships is vital as it has high heritability and could serve as biomarkers for these conditions.
  • Researchers examined MRI data from over 41,000 UK participants to conduct genome-wide association studies on 24 hippocampal and subfield volume traits and assessed their genetic correlations with 10 neuropsychiatric traits.
  • They identified 352 genetic variants related to these traits and found specific genes associated with various conditions, concluding that changes in hippocampal structures are linked to an increased risk of Parkinson's disease.
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Palladium (Pd) capture from high-level liquid waste for subsequent photocatalytic applications is desirable for the development of nuclear energy and the reutilization of valuable resources. Herein, we approach our design with a unique porous organic polymer containing thiazolo[5,4-]thiazole units (denoted as TzPOP-OH). It possesses two potential soft-hard (N-O and S-O) combined coordination sites for Pd(II) coordination and features strong donor-acceptor repeating units and high planarity of linkage enforced by hydrogen bonds for subsequent photocatalysis.

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Antibiotics are widely used in the breeding production of Bamei pigs, affecting the quality and safety of pork and causing enormous harm to human health, the environment, and public health. The use of probiotic fermented feed to replace antibiotic feed is one of the solutions, which has the potential to improve the intestinal microbiota, promote animal growth, and enhance immunity. The purpose of this study was to evaluate the effect of fermented feed with (L.

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Deciphering the composition of the tumor microenvironment (TME) is critical for understanding tumorigenesis and to design immunotherapies. In the present study, we mapped genetic effects on cell-type proportions using single-cell and bulk RNA sequencing data, identifying 3,494 immunity quantitative trait loci (immunQTLs) across 23 cancer types from The Cancer Genome Atlas. Functional annotation revealed regulatory potential and we further assigned 1,668 genes that regulate TME composition.

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This study investigated the causal enhancing effect of transcranial photobiomodulation (tPBM) over the left inferior frontal gyrus (LIFG) on syntactically complex Mandarin Chinese first language (L1) and second language (L2) sentence processing performances. Two (L1 and L2) groups of participants (thirty per group) were recruited to receive the double-blind, sham-controlled tPBM intervention via LIFG, followed by the sentence processing, the verbal working memory (WM), and the visual WM tasks. Results revealed a consistent pattern for both groups: (a) tPBM enhanced sentence processing performance but not verbal WM for linear processing of unstructured sequences and visual WM performances; (b) Participants with lower sentence processing performances under sham tPBM benefited more from active tPBM.

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Biomolecular machines autonomously convert energy into functions, driving systems away from thermodynamic equilibrium. This energy conversion is achieved by leveraging complex, kinetically asymmetric chemical reaction networks that are challenging to characterize precisely. In contrast, all known synthetic molecular systems in which kinetic asymmetry has been quantified are well described by simple single-cycle networks.

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The structure of human language is inherently hierarchical. The left posterior inferior frontal gyrus (LpIFG) is proposed to be a core region for constructing syntactic hierarchies. However, it remains unclear whether LpIFG plays a causal role in syntactic processing in Mandarin Chinese and whether its contribution depends on syntactic complexity, working memory, or both.

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  • The study focuses on creating a risk prediction model for early detection of colorectal neoplasms, specifically targeting high-risk individuals in the East Asian population to reduce cancer burden through timely interventions.
  • Researchers developed three polygenic risk scores (PRS) using previous CRC risk loci, SNP selection from large data, and a Bayesian prediction approach, validating their effectiveness in large sets of patients and normal individuals from different studies.
  • The optimized PRS showed improved risk assessment across various stages of neoplasm development and confirmed a significant dose-response effect in both East Asian and European cohorts, indicating its potential for personalized screening.
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  • Dysregulation of enhancer transcription and the role of enhancer RNAs (eRNAs) in cancer is explored, aiming to identify genetic factors influencing eRNA expression to better understand cancer mechanisms.! -
  • Researchers conducted a detailed analysis of eRNA quantitative trait loci (eRNAQTLs) in colorectal cancer samples from China, integrating epigenomic and genetic data from over 154 CRC cases to establish the first eRNAQTL profiles.! -
  • A total of 300,112 eRNAQTLs were identified across various cancers, highlighting their connection to cancer risk and potential therapeutic targets, with a specific focus on an eRNAQTL variant (rs3094296-T) that reduces colorectal cancer risk in Chinese
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Rice anaerobic fermentation is a significant source of greenhouse gas (GHG) emissions, and in order to efficiently utilize crop residue resources to reduce GHG emissions, rice straw anaerobic fermentation was regulated using lactic acid bacteria (LAB) inoculants (FG1 and TH14), grass medium (GM) to culture LAB, and (AC). Microbial community, GHG emission, dry matter (DM) loss, and anaerobic fermentation were analyzed using PacBio single-molecule real-time and anaerobic fermentation system. The epiphytic microbial diversity of fresh rice straw was extremely rich and contained certain nutrients and minerals.

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Due to the similar sources of swage irrigation, organic fertilizer, and sludge application, microplastics (MPs) and antibiotics coexist inevitably in the agriculture soils. However, the impacts of MPs with different polymer types and aging status on the bio-accessibility of co-existing antibiotics in soils remained unclear. Therefore, we using the diffusive gradients films for organic compounds devices (o-DGT) to evaluated the distribution of sulfadiazine (SDZ) in both paddy soil and saline soil amended with 0.

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Objective: This study aims to investigate the relationship between psychological resilience, thriving at work, and work performance among nurses, as well as analyse the mediating role of thriving at work in the relationship between psychological resilience and the work performance of nurses. The findings are intended to serve as a reference for nursing managers to design tailored work performance intervention programs.

Method: Using convenience sampling, 308 clinical nurses were selected from a tertiary hospital in Changsha City, Hunan Province, China, from February to April 2023.

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  • Purebred Bamei piglets face challenges like slow growth and respiratory issues, prompting this study to explore how fermented feed (QP28-1 and QB8) impacts their growth, immunity, and gut health.*
  • The experiment involved 48 piglets divided into four diet groups over 28 days, with those consuming the mixed fermented feed showing significant improvements in weight gain, feed efficiency, and immune factor levels compared to the control group.*
  • Findings revealed that fermented feed enhanced gut microbiota diversity and increased beneficial bacteria, which correlated with improved immunity, ultimately indicating that this feed type effectively supports healthier growth in Bamei piglets.*
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Heparin is one of the most widely used natural drugs, and has been the preferred anticoagulant and antithrombotic agent in the clinical setting for nearly a century. Heparin also shows increasing therapeutic potential for treating inflammation, cancer, and microbial and viral diseases, including COVID-19. With advancements in synthetic biology, heparin production through microbial engineering of heparosan offers a cost-effective and scalable alternative to traditional extraction from animal tissues.

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Root exudates are pivotal in plant stress responses, however, the impact of microplastics (MPs) on their release and characteristics remains poorly understood. This study delves into the effects of 0.05 % and 0.

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The development of efficient and selective organic synthetic approaches for complex molecules has garnered significant attention due to the need for precise control over molecular structures and functions. Rotaxanes, a type of mechanically interlocked molecules (MIMs), have shown promising applications in various fields including sensing, catalysis, and material science. However, the highly selective synthesis of oligo[n]rotaxanes (mostly n≥3) through controlling host-guest complexation and supramolecular threading assembly process still remains an ongoing challenge.

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Feed shortage in the tropics is a major constraint to the production of livestock products such as milk and meat. In order to effectively utilize of local feed resources, the selected lactic acid bacteria (LAB) strain was used to prepare Napier grass and sugarcane top silage. The results showed that the two silages inoculated with LAB formed a co-occurrence microbial network dominated by during the fermentation process, regulated the microbial community structure and metabolic pathways, and improved the silage fermentation quality.

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Background: Dietary patterns have been associated with several cancers, especially gastrointestinal cancer (GIC). However, whether a healthy dietary pattern could modify the risk of GIC among people with different genetic backgrounds is not clear.

Objective: The objective of the study was to investigate how dietary patterns and genetic susceptibility contribute to the risk of GIC independently and jointly.

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  • Left ventricular regional wall thickness (LVRWT) is a key factor influencing health outcomes in cardiovascular diseases (CVDs), and researchers developed a deep learning method to measure it in over 42,000 individuals using cardiac imaging.
  • Genome-wide studies found 72 genetic loci related to various LVRWT measurements, suggesting their involvement in heart development and function.
  • The study also linked certain LVRWT traits to hypertrophic cardiomyopathy (HCM), indicating that genetic factors can help identify individuals at higher risk for this condition.
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