Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2.

Free fatty acid receptors (FFARs) play critical roles in metabolic regulation and are potential therapeutic targets for metabolic and inflammatory diseases. A comprehensive understanding of the activation mechanisms and endogenous ligand selectivity of FFARs is essential for drug discovery. Here, we report two cryoelectron microscopy structures of the human FFAR1 bound to the endogenous ligand docosahexaenoic acid (DHA) and G protein as well as FFAR2 in complex with butyrate and G at 3.

Anti-Blast Performance of Polyurea-Coated Concrete Arch Structures.

With the increasing number of violent terrorist attacks around the world, it is quite a common to improve the anti-blast performance of structures by reinforcing the exterior of the structure. In order to explore the dynamic performance of polyurea reinforced concrete arch structures, a three-dimensional finite element model was established by LS-DYNA software in this paper. Under the condition of ensuring the validity of the simulation model, the dynamic response of the arch structure under the blast load is investigated.