Adipose tissue inflammation is now considered to be a key process underlying metabolic diseases in obese individuals. However, it remains unclear how adipose inflammation is initiated and maintained or the mechanism by which inflammation develops. We found that () expression in adipose tissue is progressively increased with the development of dietary obesity in obese mice and humans.
View Article and Find Full Text PDFThe purpose of the study is to investigate the effect of ternary systems consisting of meloxicam with cyclodextrins (HP-β-CD or SBE-β-CD) and different polymers (HA, HPMC and PVP) on the stability of meloxicam. The values of meloxicam were determined within all the aforementioned systems and the influence of various polymers on the alteration in meloxicam's stability was evaluated. All three polymers altered the stability of meloxicam to varying degrees, with the extent of the effect being related to hydrophilicity, concentration of components, and the interaction of the newly formed ternary system.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2023
Rapid implementation of renewable energy technologies has exacerbated the potential for economic loss and safety concerns caused by ice and frost accretion, which occurs on the surfaces of wind turbine blades, photovoltaic panels, and residential and electric vehicle air-source heat pumps. The past decade has seen advances in surface chemistry and micro- and nanostructures that can promote passive antifrosting and enhance defrosting. However, the durability of these surfaces remains the major obstacle preventing real-life applications, with degradation mechanisms remaining poorly understood.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2023
Millions of years of evolution have allowed animals to develop unusual locomotion capabilities. A striking example is the legless-jumping of click beetles and trap-jaw ants, which jump more than 10 times their body length. Their delicate musculoskeletal system amplifies their muscles' power.
View Article and Find Full Text PDFDroplet transport on, and shedding from, surfaces is ubiquitous in nature and is a key phenomenon governing applications including biofluidics, self-cleaning, anti-icing, water harvesting, and electronics thermal management. Conventional methods to achieve spontaneous droplet shedding enabled by surface-droplet interactions suffer from low droplet transport velocities and energy conversion efficiencies. Here, by spatially confining the growing droplet and enabling relaxation rationally designed grooves, we achieve single-droplet jumping of micrometer and millimeter droplets with dimensionless jumping velocities * approaching 0.
View Article and Find Full Text PDFOral hydroxycamptothecin nanosuspension (HCPT-Nano) with high supersaturated dissolution level, high permeation and well physical stability, was manufactured by microprecipitation-high press homogenization method. Its pharmaceutical properties were investigated, such as size and distribution, zeta potential, particle shape, physical existence condition, supersaturated dissolution level and so on. Particle size was measured by laser diffraction, and the mean diameters before and after lyophilization were 138 +/- 11.
View Article and Find Full Text PDFTo improve the encapsulation efficiency and oral bioavailability of vincristine sulfate (VCR), novel self-assembled dextran sulphate-PLGA hybrid nanoparticles (DPNs) were successfully developed using self-assembly and nanoprecipitation method. By introducing the negative polymer of dextran sulphate sodium (DS), VCR was highly encapsulated (encapsulation efficiency up to 93.6%) into DPNs by forming electrostatic complex.
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