Hydrogen Sulfide in Musculoskeletal Diseases: Molecular Mechanisms and Therapeutic Opportunities.

Musculoskeletal diseases seriously affect global health, but their importance is greatly underestimated. These diseases often afflict the elderly, leading to disability, paralysis, and other complications. Hydrogen sulfide (HS) plays an important role in the occurrence and development of musculoskeletal diseases, which may have potential therapeutic significance for these diseases.

Emerging roles of hydrogen sulfide in colorectal cancer.

Hydrogen sulfide (HS), an endogenous gasotransmitter, plays a key role in several critical physiological and pathological processes in vivo, including vasodilation, anti-infection, anti-tumor, anti-inflammation, and angiogenesis. In colorectal cancer (CRC), aberrant overexpression of HS-producing enzymes has been observed. Due to the important role of HS in the proliferation, growth, and death of cancer cells, HS can serve as a potential target for cancer therapy.

Phase-Sensitive Quantum Measurement without Controlled Operations.

Many quantum algorithms rely on the measurement of complex quantum amplitudes. Standard approaches to obtain the phase information, such as the Hadamard test, give rise to large overheads due to the need for global controlled-unitary operations. We introduce a quantum algorithm based on complex analysis that overcomes this problem for amplitudes that are a continuous function of time.

The application of a medium-chain fatty diet and enteral nutrition in post-operative chylous leakage: analysis of 63 patients.

Background: Post-operative chylous leakage (CL) is the pathologic leakage of chylomicron fluid after surgery. This retrospective study was performed to evaluate a uniform oral nutrition management strategy on the post-operative CL.

Methods: We retrospectively reviewed patients who developed post-operative CL and received consultation from a clinical nutritionist in seven departments of the Second Affiliated Hospital of Dalian Medical University from May 2020 to April 2022.

Effect of Deposition Temperature on Long-Term Residual Stress Evolution of Au Films.

To increase the residual stress stability of Au films while reducing the residual stress level, the effect of deposition temperature on long-term residual stress evolution of Au films under different conditions were studied. Au films with a thickness of 360 nm were deposited using e-beam evaporation on fused silica under different temperatures. Observations and comparisons were made of the microstructures of Au films deposited under different temperatures.

The Role of Hydrogen Sulfide in the Development and Progression of Lung Cancer.

Lung cancer is one of the 10 most common cancers in the world, which seriously affects the normal life and health of patients. According to the investigation report, the 3-year survival rate of patients with lung cancer is less than 20%. Heredity, the environment, and long-term smoking or secondhand smoke greatly promote the development and progress of the disease.

Characteristics of Gastric Microbiota in GK Rats with Spontaneous Diabetes: A Comparative Study.

Background: The Goto-Kakizaki (GK) rat, developed from repeated inbreeding of glucose-intolerant Wistar rats, has been widely used to explore the development of spontaneous type-2 diabetes mellitus (T2DM). However, the gastric microbiota of GK and Wistar rats are still unclear. This study aimed to understand the gastric microbiota characteristics of GK rats by comparing it with non-diabetic Wistar rats.

Probing Thermalization through Spectral Analysis with Matrix Product Operators.

We combine matrix product operator techniques with Chebyshev polynomial expansions and present a method that is able to explore spectral properties of quantum many-body Hamiltonians. In particular, we show how this method can be used to probe thermalization of large spin chains without explicitly simulating their time evolution, as well as to compute full and local densities of states. The performance is illustrated with the examples of the Ising and PXP spin chains.

Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis.

Background: Whether to conduct enteral nutrition in patients with severe acute pancreatitis (SAP) during the active phase of intestinal stress or to feed during remission remains controversial. This study was aimed to evaluate the efficacy and safety of enteral nutrition within 48 hours after admission in the patients with SAP or predicted severe acute pancreatitis (pSAP).

Methods: We searched PubMed, EMBASE, Web of Science, and the Cochrane Library before December 2017.

Dai-Huang-Fu-Zi-Tang Alleviates Intestinal Injury Associated with Severe Acute Pancreatitis by Regulating Mitochondrial Permeability Transition Pore of Intestinal Mucosa Epithelial Cells.

Objective: The aim of the present study was to examine whether Dai-Huang-Fu-Zi-Tang (DHFZT) could regulate mitochondrial permeability transition pore (MPTP) of intestinal mucosa epithelial cells for alleviating intestinal injury associated with severe acute pancreatitis (SAP).

Methods: A total of 72 Sprague-Dawley rats were randomly divided into 3 groups (sham group, SAP group, and DHFZT group, = 24 per group). The rats in each group were divided into 4 subgroups ( = 6 per subgroup) accordingly at 1, 3, 6, and 12 h after the operation.

Automatic characterization of classic choroidal neovascularization by using AdaBoost for supervised learning.

Purpose: To provide a computer-aided visualization tool for accurate diagnosis and quantification of choroidal neovascularization (CNV) on the basis of fluorescence leakage characteristics.

Methods: All image frames of a fluorescein angiography (FA) sequence are first aligned and mapped to a global space. To automatically determine the severity of each pixel in the global space and hence the extent of CNV, the system matches the intensity variation of each set of spatially corresponding pixels across the sequence with the targeted leakage pattern, learned from a sampled population graded by a retina specialist.