Introduction: Difamilast has proven to be an effective treatment for the treatment of atopic dermatitis (AD) in Japan, but its cost-effectiveness remains unknown. Therefore, the objective of the current study was to determine the cost-effectiveness of difamilast 1% compared with delgocitinib 0.5% in Japanese adult patients with moderate-to-severe AD and compared with placebo in Japanese adult patients with all-severity AD from a Japanese public health-care perspective.
View Article and Find Full Text PDFIntroduction: Acne vulgaris, one of the most common skin conditions, affects up to 85% of late adolescents, currently no universally accepted assessment system. The biomechanical properties of skin provide valuable information for the assessment and management of skin conditions. Wave-based optical coherence elastography (OCE) quantitatively assesses these properties of tissues by analyzing induced elastic wave velocities.
View Article and Find Full Text PDFIn covariate-adaptive or response-adaptive randomization, the treatment assignment and outcome can be correlated. Under this situation, the re-randomization test is a straightforward and attractive method to provide valid statistical inferences. In this paper, we investigate the number of repetitions in tests.
View Article and Find Full Text PDFFront Bioeng Biotechnol
September 2024
Background: Atopic dermatitis (AD) is a chronic condition with an increasing incidence in Japan. Difamilast and delgocitinib are both new topical drugs for AD proven to be efficacious and safe in phases 2 and 3 clinical trials in Japan. However, there are no head-to-head trials comparing their efficacy and safety.
View Article and Find Full Text PDFOptical Coherence Tomography (OCT)-based angiography (OCTA) is a high-resolution, high-speed, and non-invasive imaging method that can provide vascular mapping of subcutaneous tissue up to approximately 2 mm. In dermatology applications of OCTA, handheld probes are always designed with a piece of transparent but solid contact window placed at the end of the probe to directly contact the skin for achieving better focusing between the light source and the tissue, reducing noise caused by minor movements. The pressure between the contact window and the skin is usually uncontrollable, and high external pressure affects the quality of microvascular imaging by compressing the vessels and obstructing the underlying blood flow.
View Article and Find Full Text PDFElectrophysiological monitoring is a commonly used medical procedure designed to capture the electrical signals generated by the body and promptly identify any abnormal health conditions. Wearable sensors are of great significance in signal acquisition for electrophysiological monitoring. Traditional electrophysiological monitoring devices are often bulky and have many complex accessories and thus, are only suitable for limited application scenarios.
View Article and Find Full Text PDFThe current methods to generate projections for structural and angiography imaging of Fourier-Domain optical coherence tomography (FD-OCT) are significantly slow for prediagnosis improvement, prognosis, real-time surgery guidance, treatments, and lesion boundary definition. This study introduced a robust ultrafast projection pipeline (RUPP) and aimed to develop and evaluate the efficacy of RUPP. RUPP processes raw interference signals to generate structural projections without the need for Fourier Transform.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Developing nanozymes for cancer therapy has attracted great attention from researchers. However, enzymes-loaded magnetic particles triggered by both a low-frequency vibrating magnetic field (VMF) and laser for inhibiting tumor growth have never been reported. Herein, we developed a magnetic nanozyme with 3D flower-like nanostructures for cancer therapy.
View Article and Find Full Text PDFDecne. (Family Rhamnaceae Juss.) leaf is commonly prepared as a anti-inflammatory herbal medicine and used for tea production.
View Article and Find Full Text PDFThe development of electrochemical energy storage devices has a decisive impact on clean renewable energy. Herein, novel ultrafast rechargeable hybrid sodium dual-ion capacitors (HSDICs) were designed by using ultrathin carbon film (UCF) as the cathode material. The UCF is synthesized by a simple low temperature catalytic route followed by an acid leaching process.
View Article and Find Full Text PDFStat Theory Relat Fields
September 2023
Missing data is unavoidable in longitudinal clinical trials, and outcomes are not always normally distributed. In the presence of outliers or heavy-tailed distributions, the conventional multiple imputation with the mixed model with repeated measures analysis of the average treatment effect (ATE) based on the multivariate normal assumption may produce bias and power loss. Control-based imputation (CBI) is an approach for evaluating the treatment effect under the assumption that participants in both the test and control groups with missing outcome data have a similar outcome profile as those with an identical history in the control group.
View Article and Find Full Text PDFBackground And Objectives: Fremanezumab is an effective treatment for episodic (EM) and chronic migraine (CM) patients in Japan, but its cost effectiveness remains unknown. The objective of this study was to determine the cost effectiveness of fremanezumab compared with standard of care (SOC) in previously treated EM and CM patients from a Japanese healthcare perspective.
Methods: Estimated regression models were implemented in a probabilistic Markov model to inform effectiveness and health-related quality-of-life data for fremanezumab and SOC.
The mining of the protective coal seam usually produces different pressure relief effects on the different areas of protected coal seam, the reason is that the stress paths of protected seam coal body in different areas caused by mining effect are different. In order to explore the differential pressure relief damage effect of coal body under different pressure relief conditions, the stress evolution path of coal body in different areas of the protected coal seam is obtianed by using theoretical analysis and the macro-micro damage characteristics of coal body under different stress paths by using numerical simulation in this paper. The results show that: The damage characteristics of the sample models are basically the same in the in-situ stress recovery stage and the mining disturbance stage of the two stress paths.
View Article and Find Full Text PDFLongitudinal studies are often subject to missing data. The recent guidance from regulatory agencies, such as the ICH E9(R1) addendum addresses the importance of defining a treatment effect estimand with the consideration of intercurrent events. Jump-to-reference (J2R) is one classical control-based scenario for the treatment effect evaluation, where the participants in the treatment group after intercurrent events are assumed to have the same disease progress as those with identical covariates in the control group.
View Article and Find Full Text PDFNitrate, which poses a serious threat to the drinking water supply, is one of the most prevalent anthropogenic groundwater contaminants worldwide. With the development of the chemical industry, the nitrate pollution of groundwater in the Piedmont strong runoff zone of the Hohhot Basin, which is the main groundwater extraction area, is becoming increasingly severe. The special hydrogeological and complex pollution conditions in the study area make it difficult to identify nitrate sources and transformation processes.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
April 2024
External fingerprints (EFs) based only on epidermal information are vulnerable to spoofing attacks and non-ideal skin conditions. To solve such shortcomings, internal fingerprints (IFs) collected using optical coherence tomography (OCT) have been proposed and widely researched. However, the development of IF is limited by the lack of in-depth researches on the IF and the EF-IF interoperability, which is partially caused by the lack of public OCT database.
View Article and Find Full Text PDFHigh-intensity ultrasound was used as a means to promote maturation of soy sauce. The optimal conditions for ultrasound treatment were 90℃ at an ultrasound intensity of 39.48 W/cm for 60 min.
View Article and Find Full Text PDFOptical coherence tomography angiography (OCTA) is a non-invasive imaging modality for analyzing skin microvasculature, enabling non-invasive diagnosis and treatment monitoring. Traditional OCTA algorithms necessitate at least two-repeated scans to generate microvasculature images, while image quality is highly dependent on the repetitions of scans (e.g.
View Article and Find Full Text PDFMulti-segmental lumbar degenerative disease, including intersegmental disc degeneration, is found in clinical practice. Controversy still exists regarding the treatment for cross-segment degeneration. Oblique Lateral Interbody Fusion (OLIF) with several internal fixations was used to treat cross-segment lumbar degenerative disease.
View Article and Find Full Text PDFOptical coherence tomography (OCT) is a noninvasive high-resolution imaging technology that can accurately acquire the internal characteristics of tissues within a few millimeters. Using OCT technology, the internal fingerprint structure, which is consistent with external fingerprints and sweat glands, can be collected, leading to high anti-spoofing capabilities. In this paper, an OCT fingerprint anti-spoofing method based on a 3D convolutional neural network (CNN) is proposed, considering the spatial continuity of 3D biometrics in fingertips.
View Article and Find Full Text PDFBackground: There are some cases of Klippel-Feil syndrome with spinal cord injury in clinical work. However, there is no literature report on Brown-Sequard syndrome after trauma. We report a case of Brown-Sequard syndrome following minor trauma in a patient with KFS type III.
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