Publications by authors named "Yilmaz Tabel"
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare, mostly complement-mediated thrombotic microangiopathy. The majority of patients are infants. In contrast to infantile-onset aHUS, the clinical and genetic characteristics of adolescence-onset aHUS have not been sufficiently addressed to date.
View Article and Find Full Text PDFObjective: Natural disasters cause enormous environmental, economic, and human losses. Children are the most vulnerable group and face severe consequences. While the primary cause of post-traumatic death is direct injury, the secondary cause is crush syndrome (CS).
View Article and Find Full Text PDFPediatric kidney care experience after the 2023 Türkiye earthquake.
Nephrol Dial Transplant
August 2024
Article Synopsis
- Two devastating earthquakes in Türkiye on February 6, 2023, resulted in significant injuries to 903 children, with a focus on crush syndrome-related acute kidney injury (Crush-AKI) and mortality.
- The study tracked various factors, including the time under rubble, treatment protocols, and patient outcomes, revealing that Crush-AKI developed in 36% of the patients, and over half required dialysis.
- Key findings included that serum levels of creatine phosphokinase above 20,950 U/L and inadequate initial intravenous fluid volume were linked to Crush-AKI, and most deaths occurred among those with Crush-AKI within the first four days of admission.
Article Synopsis
- Myelomeningocele (MMC) is a condition that affects many kids in developing countries like Turkey, and it can lead to kidney problems known as chronic kidney disease (CKD).
- A study in Turkey looked at children with MMC to find out how many had different stages of CKD and what factors made their kidney health worse.
- The results showed that 5.3% of the kids had CKD stage 5, and certain medical conditions were linked to an increased risk of serious kidney problems. To help these kids, doctors suggest taking early action in managing their bladder issues to prevent kidney failure.
Uroflowmetry parameters in healthy children between 5 and 15 years old.
Low Urin Tract Symptoms
November 2023
Objectives: Uroflowmetry (UFM) is the first-line noninvasive screening test employed in the diagnosis of lower urinary tract dysfunction (LUTD). The purpose of this study was to determine normal UFM values in healthy Turkish children among our local population.
Methods: A total of 100 healthy girls and 62 healthy boys aged 5-15 years, who applied to İnönü University Turgut Özal Medical Center Pediatrics Polyclinic between February 2021 and January 2022, were included in the present study.
Article Synopsis
- The study focuses on urinary tract infections (UTIs) in children and investigates the potential use of soluble Toll-like receptors (sTLR4, sTLR5) and interleukin 8 (IL-8) as biomarkers for diagnosing UTIs.
- It involved 520 children, including those with UTIs, non-UTI infections, and healthy controls, measuring urine and serum levels of the biomarkers before and after treatment.
- Results show that urine sTLR4 levels are higher in UTI patients, with a cut-off level identified to predict UTIs, especially higher in cases of pyelonephritis compared to cystitis, and decreasing post-treatment.
Background: Alport syndrome (AS) is characterized by progressive kidney disease. There is increasing evidence that renin-angiotensin-aldosterone system (RAAS) inhibition delays chronic kidney disease (CKD) while the effectiveness of immunosuppressive (IS) therapy in AS is still uncertain. In this study, we aimed to analyze the outcomes of pediatric patients with X-linked AS (XLAS) who received RAAS inhibitors and IS therapy.
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- * Common neuropsychiatric symptoms included headaches (50.3%), seizures (38.3%), and acute confusional states (33.6%), with five distinct clusters of symptoms identified based on their clinical and laboratory findings.
- * Key factors associated with increased risk of neurologic issues included positivity for antiphospholipid antibodies, history of plasmapheresis treatment, and higher SLEDAI scores, providing insights for better diagnosis and management.
Article Synopsis
- A new study looked at a special urine test called uHSP70 to help tell if kids have a urinary tract infection (UTI) instead of just using regular tests that might not be very reliable.
- The study involved 802 kids and found that uHSP70 levels were much higher in kids with UTI compared to those with other infections or who were healthy.
- Using uHSP70 could help doctors correctly diagnose UTIs and might stop about 80% of kids from getting unnecessary antibiotics.
Purpose: The presence and degree of hydronephrosis is very important in the management of many diseases of the urinary tract. In this study, we aim to compare the sensitivity and specificity of 2 classification systems that are used for hydro-nephrosis grading in ultrasound, for reflux and scar detection. The classification systems were the Society of Fetal Urology (SFU) and Urinary Tract Dilatation (UTD).
View Article and Find Full Text PDFBackground: Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by abdominal and chest pain and recurrent fever due to inflammation in the serosal membranes such as peritoneum, pleura and synovia. In FMF, recurrent inflammatory cytokine production may lead to cirrhosis. The aim of this study was to determine the prevalence of FMF in children with cryptogenic cirrhosis and it was found to be high, to add FMF among the etiological causes of cirrhosis.
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- The study investigated the kidney disease profiles of Syrian refugee children in Turkey, highlighting their vulnerability and specific health issues within conflict zones.
- Data from 633 children revealed that congenital anomalies of the kidney and urinary tract (CAKUT), glomerular disease, and chronic kidney disease (CKD) were the most common conditions, with significant demographic factors like parental consanguinity and familial history of kidney disease noted.
- Challenges faced during follow-up included language barriers, lack of medical records, and disruptions in care, which emphasize the need for improved treatment options and preventive measures for these children.
Objective: Many cardiovascular complications, including hypertension, are seen in pediatric liver transplantation. The purpose of this study was to analyze the frequency of arterial hypertension of pediatric liver transplant recipients and also to determine the related risk factors.
Methods: Thirty-six pediatric liver transplant recipients aged 8-17 years were prospectively studied by manual and ambulatory blood pressure measurement (ABPM) technique.
In this study, our aim was to evaluate the significance of the change in renal pelvis anterior-posterior diameter (RPAPD) before and after micturition between vesicoureteral reflux (VUR)-positive and -negative patients to whom had voiding cystourethrography (VCUG) was performed.In this study, 69 children, age ranging from 0 to 12 years, were included. Before the VCUG imaging, the RPAPD was measured first with a full bladder and then after urination via ultrasound (US).
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- C3 glomerulopathy (C3G) is a rare kidney disease impacting children, characterized by C3 protein buildup in the glomeruli and marked by variable clinical outcomes and symptoms.
- In a study of 60 pediatric patients in Turkey, findings showed common symptoms like hematuria and hypertension, with nephritic-nephrotic syndrome being the most frequent presentation.
- Key predictors of progression to chronic kidney disease stage 5 (CKD5) include lower baseline kidney function (eGFR) and serum albumin levels, highlighting the need for close monitoring in affected children.
Prevalence estimates of voiding disorders in Turkish school-age children.
Low Urin Tract Symptoms
April 2021
Objectives: This study aims to investigate the prevalence of voiding disorders and identify the associated risk factors for school-age children in East Anatolia, Turkey.
Methods: We randomly selected six primary schools in Malatya in East Anatolia, and 907 students from 6 to 14 years old were involved. Data were obtained using the dysfunctional voiding and incontinence scoring system (DVISS) scale, and children who scored 8.
Acute kidney injury and peritoneal dialysis in extremely low birth weight newborns.
Minerva Pediatr (Torino)
October 2023
Background: In 12.5-56% of extremely low birth weight (ELBW) infants treated in newborn units, acute kidney injury (AKI) develops. Some of these infants may need renal replacement therapy for several reasons including hyperkalemia, hypovolemia and resistant acidosis.
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- Urinary epidermal growth factor (uEGF) has been identified as a potential biomarker for predicting the progression of chronic kidney disease (CKD) in both adults and children, particularly reflecting kidney damage.
- In a study of children with CKD, higher levels of uEGF relative to creatinine (uEGF/Cr) were linked to a reduced risk of CKD progression, even after accounting for other factors like age and kidney function.
- The findings indicate that measuring uEGF could enhance the prediction of CKD progression in pediatric patients, making it a valuable tool for better management of the disease.
Background: There is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients.
Methods: Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography.