Prolonged respiratory failure responds to conventional therapy in isolated homocysteine remethylation defects.

Isolated remethylation defects are rare inherited diseases caused by a defective remethylation of homocysteine to methionine, preventing various essential methylation reactions to occur. Patients present with a systemic phenotype, which can especially affect the central and peripheral nervous systems leading to epileptic encephalopathy, developmental delay and peripheral neuropathy. Respiratory failure has been described in some cases, caused by both central and peripheral neurological involvement.

Assessment of the oxidative damage and apoptotic pathway related to furan cytotoxicity in cultured mouse Leydig cells.

Research on heat-induced food contamination is being given more attention as a result of the health risks that have been publicly revealed in recent years. Furan is known as a colorless, combustible, heterocyclic aromatic organic molecule and is formed when food products are processed and stored. It has been established that furan, which is inevitably ingested, has a deleterious impact on human health and causes toxicity.

How does exercise affect energy metabolism? An approach for cardiac muscle.

We explored an model of muscle energy metabolism and demonstrated its theoretical plausibility. Results indicate that energy metabolism triggered by activation can capture the muscle condition, rest, or exercise, and can respond accordingly adjusting the rates of their respiration and energy utilization for efficient use of the nutrients. Our study demonstrated during exercise higher respiratory activity causes a substantial increase in exergy release with an increase in exergy destruction, and entropy generation rate.

D-Lactate: Implications for Gastrointestinal Diseases.

D-lactate is produced in very low amounts in human tissues. However, certain bacteria in the human intestine produce D-lactate. In some gastrointestinal diseases, increased bacterial D-lactate production and uptake from the gut into the bloodstream take place.

Influence of occlusal collision corrections completed by two intraoral scanners or a dental design program on the accuracy of the maxillomandibular relationship.

Statement Of Problem: Occlusal collisions of articulated intraoral digital scans can be corrected by intraoral scanners (IOSs) or dental design software programs. However, the influence of these corrections on the accuracy of maxillomandibular relationship is unclear.

Purpose: The purpose of this clinical investigation was to measure the effect of occlusal collision corrections completed by the IOSs or dental design software programs on the trueness and precision of maxillomandibular relationship.

Effect of layer thickness, build angle, and viscosity on the mechanical properties and manufacturing trueness of denture base resin for digital light processing.

Objectives: To investigate effects of layer thickness, build angle, and viscosity on the mechanical properties and trueness of denture base resins used for digital light processing (DLP).

Methods: Two denture base resins for DLP in different viscosity (high and low) were tested by using two manufacturing parameters:1) layer thickness (LT) (50- or 100-μm) and 2) build angle (BA) (0-, 45-, and 90-degree). disk- and bar-shaped specimens were used to evaluate hardness and flexural strength, respectively.

Vaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkey.

Objective: Vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-2) prevents the development of serious diseases has been shown in many studies. However, the effect of vaccination on outcomes in COVID-19 patients requiring intensive care is not clear.

Methods: This is a retrospective multicenter study conducted in 17 intensive care unit (ICU) in Turkey between January 1, 2021, and December 31, 2021.

Cervical Dysplasia Distress Questionnaire: Turkish validity and reliability study.

The aim of this study was to determine the validity and reliability of the Turkish adaptation of the Cervical Dysplasia Distress Questionnaire (CDDQ) in women with abnormal Pap smear results. This validation study was conducted using a cross-sectional research design. A total of 115 patients who were being followed up in the obstetrics and gynecology outpatient clinic of a university hospital due to an abnormal Pap smear test were included.

Efficacy of BNT162b2 and CoronaVac in patients diagnosed with COVID-19.

This retrospective observational study is aimed to determine the efficacy of BNT162b2 (Pfizer-BioNTech) and CoronaVac (Sinovac) vaccines against symptomatic or severe disease in COVID-19-diagnosed patients. The secondary aim was to define the differences between vaccinated and un-vaccinated patients in terms of age, comorbidities and course of the disease, and to determine the survival rates. Of the 1463 PCR-positive patients, 55.

Acquired changes in thickness and length of patellar tendon after primary total knee arthroplasty: a prospective ultrasonographic study with over 4 years of follow-up.

Previous literature has reported changes in the length or thickness of the patellar tendon (PT) following primary total knee arthroplasty (TKA). This study aims to determine the structural changes in both the length and thickness of the PT after primary TKA using ultrasound (US) and to investigate the association between these changes and clinical outcomes after a minimum follow-up of 48 months. This prospective study used the US on 60 knees of 32 patients (aged 54-80, mean 64.

Nociceptive flexion reflex in small fibers neuropathy and pain assessments†.

Background: The nociceptive flexion reflex (NFR) is a polysynaptic and multisegmental spinal reflex that develops in response to a noxious stimulus and is characterized by the withdrawal of the affected body part. The NFR possesses two excitatory components: early RII and late RIII. Late RIII is derived from high-threshold cutaneous afferent A-delta fibers, which are prone to injury early in the course of diabetes mellitus (DM) and may lead to neuropathic pain.

Determination of the degree of conversion, the diffuse reflectance, and the color stability after different aging processes of gingiva-colored composite resins.

Purpose: To determine the degree of conversion (DC) and spectral diffuse reflectance of four different gingiva-colored composites and to evaluate their color stability after various aging processes.

Materials And Methods: The gingiva-colored composites were assigned to four experimental groups (Anaxgum (AG), Crea.lign paste Gum (CB), Gradia Gum (GR), SR Nexco Gum (NC)).

The Effect of the Meditation Based Mandala Programme on Distress, Anxiety and Depression in the Caregivers of Cancer Patients in Palliative Care Unit.

Mental health problems were found to be more common than physical health problems in cancer caregivers in palliative care units. This is a quasi-experimental study planned to determine the effect of the meditation based mandala programme on distress, anxiety and depression in caregivers of cancer patients in a palliative care unit. Planned as a single-group pre-test/post-test design, with a total of 11 caregivers.

Surgical outcomes of intraabdominal versus vaginal approach for uterine manipulation during total laparoscopic hysterectomy.

Uterine manipulation is essential for moving the uterus and proper anatomical dissection without complications during total laparoscopic hysterectomy (TLH). Although many different uterine manipulators (UM) have been designed in the last few decades, there is still no "optimal UM" that is universally safe, efficient, and cost-effective. This study aimed to compare myoma screw (MS) and UM with regard to surgical outcomes and cost-effectiveness in patients who underwent TLH.

Analysis of YouTube Videos Regarding Breastfeeding During the Coronavirus Disease (COVID-19) Pandemic.

Introduction: During the coronavirus disease (COVID-19) pandemic, which has significantly impacted public health, it is crucial to raise awareness and access to accurate information about breastfeeding for healthy growth and development. This descriptive study aimed to evaluate the content, reliability, and quality of YouTube videos on COVID-19 and breastfeeding.

Methods: The YouTube platform was searched for the English keywords "COVID-19" and "breastfeeding" in March 2021.

The effect of brace on apical vertebral derotation in adolescent idiopathic scoliosis.

Purpose: The current study aims to evaluate the effect of Boston brace treatment on apical vertebral derotation in adolescent idiopathic scoliosis (AIS) patients receiving conservative treatment.

Methods: The study included 51 AIS patients, consisting of 8 males and 43 females, with Cobb angles between 25° and 45° and Risser's findings ranging from 0 to 4. The mean age of the participants was 12.

Compromised T-cell immunity in patients with spinal cord injury and its relationship with injury characteristics.

Objectives: The aim of this study was to investigate and cellular immune responses in patients with chronic (spinal cord injury; SCI), determine the effects of autonomic dysfunction on cellular immune response, and determine the effect of completeness of the injury at different levels on cellular immune response.

Patients And Methods: Forty-nine patients (42 males, 7 females; mean age: 35.5±13.

Anna Karenina principle in personalized treatment of bladder cancer according to oncogram: which drug for which patient?

To evaluate the efficacy of chemotherapy, immunotherapy and targeted agents with the oncogram method in patients with bladder cancer and determine the most appropriate personalized treatment agent using immune markers. Bladder cancer tissues were obtained from each patient. After cultivation, cell cultures were divided into 12 groups for each patient and 11 drugs were administered.

Effect of number of supports and build angle on the fabrication and internal fit accuracy of additively manufactured definitive resin-ceramic hybrid crowns.

Objectives: To evaluate the effect of number of supports and build angle on the fabrication and internal fit accuracy (trueness and precision) of additively manufactured resin-ceramic hybrid crowns.

Methods: A mandibular first molar crown was designed and nested on the build platform of a printer either with a 30° angle between the occlusal surface and the build platform (BLS (less support) and BMS (more support)) or its occlusal surface parallel to the build platform (VLS (less support) and VMS (more support)) to fabricate additively manufactured resin-ceramic hybrid crowns (n = 14). After fabrication, supports were removed by a blinded operator and all crowns were digitized with an intraoral scanner.

Bond strength of additively manufactured composite resins to dentin and titanium when bonded with dual-polymerizing resin cements.

Statement Of Problem: Additively manufactured composite resins for definitive restorations have been recently introduced. The bond strength between these composite resins and different substrates has not been extensively studied.

Purpose: The purpose of this in vitro study was to measure the shear bond strength (SBS) between additively manufactured composite resins and dentin and titanium substrates and compare those with the SBS between subtractively manufactured polymer-infiltrated ceramic and the same substrates (dentin and titanium), when different dual-polymerizing resin cements were used.

Benchmarking microbial DNA enrichment protocols from human intestinal biopsies.

Shotgun metagenomic sequencing is a powerful tool for studying bacterial communities in their natural habitats or sites of infection, without the need for cultivation. However, low microbial signals in metagenomic sequencing can be overwhelmed by host DNA contamination, resulting in decreased sensitivity for microbial read detection. Several commercial kits and other methods have been developed to enrich bacterial sequences; however, these assays have not been tested extensively for human intestinal tissues yet.

The predictive usefulness of the novel "combined hemoglobin-to-platelet ratio and maximum mouth opening index" on prevalence of radiation induced trismus in patients with nasopharyngeal cancer.

Objectives: To explore how well a unique combination of hemoglobin-to-platelet ratio (HPR) and pretreatment maximum mouth opening (MMO) predicts the prevalence of radiation-induced trismus (RIT).

Patients And Methods: HPR and MMO cutoff values (0.54 and 40.

PRELIMINARY FINDINGS OF TLR2 AND TLR4 EXPRESSION IN PRETERM NEONATES WITH NECROTIZING ENTEROCOLITIS.

Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in preterm infants. Despite significant advances made in the prevention and treatment of disease so far, there has not been much change in the rate of mortality and morbidity associated with NEC. Although the factors affecting the development of necrotizing enterocolitis are not yet known precisely, prematurity is thought to be the most important risk factor for the development of NEC.

The results of the modified St Jude Total Therapy XV Protocol in the treatment of low- and middle-income children with acute lymphoblastic leukemia.

The St Jude Total Therapy Study XV was the first clinical trial to prospectively use minimal residual disease levels during and after remission induction therapy to guide risk-directed treatment. We used the Total Therapy XV protocol with minimal modification in treating 115 newly diagnosed pediatric acute lymphoblastic leukemia patients from low- and middle-income groups from January 2011 to December 2017. The mean age at diagnosis was 5.