Publications by authors named "Yiliu Yang"
Purpose: To assess the quantitative differences in vessel density and retinal thickness of X-linked retinoschisis (XLRS) patients and RS1 mutation carriers, and the correlation with best-corrected visual acuity (BCVA) with swept source optical coherence tomography (SS-OCT) and OCT angiography (OCTA).
Methods: We analyzed the correlation between the BCVA of XLRS patients and the SS-OCT and OCTA findings including the detailed structural characteristics of XLRS patients.
Results: Besides the schitic changes in various retinal layers, the structural disturbance of outer retina was universally found.
Blocking Th2 Signaling Pathway Alleviates the Clinical Symptoms and Inflammation in Allergic Conjunctivitis.
Invest Ophthalmol Vis Sci
July 2023
Purpose: To explore the role of Th2 signaling pathway in allergic conjunctivitis (AC).
Methods: Serum Th2 cytokines IL-4 or IL-13 of patients with AC were detected using the Meso scale discovery assay to verify the correlation of Th2 immunity and AC pathogenesis. Wistar Han rats were intraperitoneally and subcutaneously injected with ovalbumin (OVA) to establish an experimental AC model and the Th2 signaling pathway was blocked by an investigational neutralizing antibody (CM310).
Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration.
Signal Transduct Target Ther
February 2023
Article Synopsis
- The prime editor (PE) enables precise genome editing without the need for double strand breaks or extra donor templates, allowing correction of various disease-causing mutations.
- In this study, researchers optimized PE using a dual-AAV split-intein system for higher editing efficiency, particularly focusing on the placement of components in the genetic sequence.
- When tested in rd12 mice with a retinal disease, the optimized PE successfully corrected mutations with 16% efficiency, restored important gene expression, and improved both retinal and visual function without causing off-target effects.
A Rare Case of Orbitocranial Penetrating Injury with Intracranial Wooden Foreign Body Residue.
Medicina (Kaunas)
December 2022
Orbitocranial penetrating injuries (OPIs) caused by wooden foreign bodies (WFBs) are very rare and life threatening. Their diagnosis and treatment could be challenging for an ophthalmologist, requiring us to remain alert for possible intracranial extension. We present a case of a 52-year-old man with a residual wooden foreign body in the left frontal lobe.
View Article and Find Full Text PDFIncontinentia pigmenti (IP) is a rare X-linked neuroectodermal dysplasia affecting multiple organs. One of its most significant ophthalmic manifestations is retinal neovascularization due to retinal ischemia, which has been traditionally treated with laser photocoagulation or cryotherapy. The application of anti-vascular endothelial growth factor (VEGF) has been reported for the treatment of retinopathy of IP with beneficial results.
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