Loss of in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome.

Ataxia-telangiectasia mutated () is a key DNA damage signaling kinase that is mutated in humans with ataxia-telangiectasia (A-T) syndrome. This syndrome is characterized by neurodegeneration, immune abnormality, cancer predisposition, and premature aging. To better understand the function of in vivo, we engineered a viable zebrafish model with a mutated gene.