Models of sepsis-induced acute kidney injury.

Sepsis-induced acute kidney injury (S-AKI) is one of the most serious life-threatening complications of sepsis. The pathogenesis of S-AKI is complex and there is no effective specific treatment. Therefore, it is crucial to choose suitable preclinical models that are highly similar to human S-AKI to study the pathogenesis and drug treatment.

Clinical efficacy, pharmacodynamic components, and molecular mechanisms of antiviral granules in the treatment of influenza: A systematic review.

Ethnopharmacological Relevance: The Antiviral Granules (AG) are derived from the classical famous prescription, which is composed of 9 traditional Chinese medicines, namely Radix Isatidis (called Banlangen, BLG in Chinese), Forsythiae Fructus (called Lianqiao, LQ in Chinese), Gypsum fibrosum, Anemarrhenae Rhizoma (called Zhimu, ZM in Chinese), Phragmitis Rhizoma (called Lugen, LG in Chinese), Rehmanniae Radix (called Dihuang, DH in Chinese), Pogostemonis Herba (called Guanghuoxiang, GHX in Chinese), Acori Tatarinowii Rhizoma (called Shichangpu, SCP in Chinese), and Curcumae Radix (called Yujin, YJ in Chinese), and has shown an excellent therapeutic effect in clinical treatment of influenza. However, there are few studies on the anti-influenza mechanism of AG, and the mechanism of action is still unclear.

Aim Of The Study: The purpose is to provide the latest information about the clinical efficacy, pharmacodynamic composition and mechanism of AG based on scientific literature, so as to enhance the utilization of AG in the treatment of influenza and related diseases, and promote the development and innovation of novel anti-influenza drugs targeting the influenza virus.

Biological Application of Porous Aromatic Frameworks: State of the Art and Opportunities.

Porous aromatic frameworks (PAFs) were first reported in 2009 and have quickly attracted much attention because of their exceptionally ultrahigh specific surface area (5800 m·g). Uniquely, PAFs are constructed from carbon-carbon-bond-linked aromatic-based building units, which render PAFs extremely stable in various environments. At present, PAFs have been applied in many fields, such as adsorption, catalysis, ion exchange, electrochemistry, and so on.

China's plastic import ban increases prospects of environmental impact mitigation of plastic waste trade flow worldwide.

Since the late 1990s, the trend of plastic waste shipment from developed to developing countries has been increasing. In 2017, China announced an unprecedented ban on its import of most plastic waste, resulting in a sharp decline in global plastic waste trade flow and changes in the treatment structure of countries, whose impacts on global environmental sustainability are enormous but yet unexamined. Here, through the life cycle assessment (LCA) method, we quantified the environmental impacts of changes in the flow patterns and treatment methods of 6 types of plastic waste in 18 countries subsequent to the ban.

Water-energy-nutrient nexus: Multi-sectoral metabolism analysis and technical path optimization for eco-towns.

The multi-sectoral metabolisms of substance and energy in rural areas are complex, whose optimization is the key to realize resource recycling and energy cascade utilization. Through Substance Flow Analysis (SFA), we establish a Multi-sectoral Metabolism Analysis Model specific to rural areas (MMAM-rural), and investigated the multi-sectoral metabolisms of Liujiadian Town in Beijing city. We simulate the water, energy and nutrients (carbon, nitrogen and phosphorus) metabolisms of a total of five sectors (water, waste management, livestock husbandry, forestry, and residential sectors), and identify the key metabolic flows significant for improving regional metabolism performance of Liujiadian Town.

Facile Secondary Deposition for Improving Quantum Dot Loading in Fabricating Quantum Dot Solar Cells.

Sufficient loading of presynthesized quantum dots (QDs) on mesoporous TiO electrodes is the prerequisite for the fabrication of high-performance QD-sensitized solar cells (QDSCs). Here, we provide a general approach for increasing QD loading on mesoporous TiO films by surface engineering. It was found that the zeta potential of presensitized TiO can be effectively adjusted by surfactant treatment, on the basis of which additional QDs are successfully introduced onto photoanodes during secondary deposition.

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.