Conductive hyaluronic acid/phytanic acid hydrogel to deliver recombinant human amelogenin for diabetic wound repair.

Diabetic wounds present a considerable challenge in modern medicine due to their prolonged healing process, driven by sustained inflammation and impaired vascular regeneration. This study introduces a novel hydrogel network through osmosis, utilizing hyaluronic acid (HA) and phytic acid (PA) for their anti-inflammatory and antioxidant properties, respectively. By incorporating recombinant Human Amelogenin (rhAM), known for its angiogenic potential, we aimed to develop the HA-PA-rhAM hydrogel to enhance wound healing in diabetic rats.

The levels of serum lipoprotein(a) on clinical outcomes in Chinese hospitalized patients with cardiovascular diseases.

Objective: Serum lipoprotein(a) [Lp(a)] is a risk factor of cardiovascular diseases. However, the relationship between the serum Lp(a) and clinical outcomes has been seldom studied in Chinese hospitalized patients with cardiovascular diseases.

Methods: We retrospectively collected the clinical data of hospitalized patients with cardiovascular diseases in the Cardiovascular Department of Dongguan People's Hospital from 2016 to 2021 through the electronic case system.