Revealing the heterogeneity of treatment resistance in less-defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy.

Precision medicine in less-defined subtype diffuse large B-cell lymphoma (DLBCL) remains a challenge due to the heterogeneous nature of the disease. Programmed cell death (PCD) pathways are crucial in the advancement of lymphoma and serve as significant prognostic markers for individuals afflicted with lymphoid cancers. To identify robust prognostic biomarkers that can guide personalized management for less-defined subtype DLBCL patients, we integrated multi-omics data derived from 339 standard R-CHOP-treated patients diagnosed with less-defined subtype DLBCL from three independent cohorts.

Carbon-mediated modulation pathways of phytotoxicity in chicken manure composting.

Compost phytotoxicity affects the safety of organic fertilizers returned to the field, thus hindering the breeding cycle, so it is essential to reduce the compost phytotoxicity. The phytotoxicity of compost was estimated utilizing the germination index (GI) and the aqueous substances (organics and ions) present in compost correlated closely with GI. This study assessed the effect of carbon additives from different plant sources (mushroom substrates (MS), cornstalks (CS) and garden substrates (GS)) on maturity parameters (temperature, pH, EC, C/N), content of aqueous carbon and nitrogen matters, salt ions, heavy metal ions, and microbiome of piles when composting with chicken manure and especially focused on their effect on GI.

Unveiling the Enhancement of Electrocatalytic Oxygen Evolution Activity in Ru-FeO/CoS Heterojunction Catalysts.

The development of highly efficient electrocatalysts for the sluggish anodic oxygen evolution reaction (OER) is crucial to meet the practical demand for water splitting. In this study, an effective approach is proposed that simultaneously enhances interfacial interaction and catalytic activity by modifying FeO/CoS heterojunction using Ru doping strategy to construct an efficient electrocatalytic oxygen evolution catalyst. The unique morphology of Ru doped FeO (Ru-FeO) nanoring decorated by CoS nanoparticles ensures a large active surface area and a high number of active sites.

Effects of thermophilic bacteria inoculation on maturity, gaseous emission and bacterial community succession in hyperthermophilic composting.

Hyperthermophilic composting, characterized by temperatures equal to or exceeding 75 °C, offers superior compost maturity and performance. Inoculation with thermophilic bacteria presents a viable approach to achieving hyperthermophilic composting. This study investigates the effects of inoculating thermophilic bacteria, isolated at different temperatures (50 °C, 60 °C, and 70 °C) into compost on maturity, gaseous emissions, and microbial community dynamics during co-composting.

Determining the extraction conditions and phytotoxicity threshold for compost maturity evaluation using the seed germination index method.

The phytotoxicity of the compost aqueous extracts determines the maturity. To improve the accuracy of compost maturity evaluation using the seed germination index (GI) method, different extraction methods (different moisture content and extraction ratio) were designed to obtain samples with various phytotoxic level. This study analyzed the effects of different extraction condition of compost samples on GI, and established the relationship between phytotoxicity and GI.

Dynamics of antibiotic resistance genes and bacterial community during pig manure, kitchen waste, and sewage sludge composting.

Organic solid wastes (OSWs) are important reservoirs for antibiotic resistance genes (ARGs). Aerobic composting transforms OSWs into fertilizers. In this study, we investigated ARGs dynamics and their driving mechanisms in three OSW composts: pig manure (PM), kitchen waste (KC), and sewage sludge (SG).

Relating bacterial dynamics and functions to greenhouse gas and odor emissions during facultative heap composting of four kinds of livestock manure.

Although facultative heap composting is widely used in small and medium-sized livestock farms in China, there are few studies on greenhouse gas (GHG) and odor emissions from this composting system. This study focused on GHG and odor emissions from facultative heap composting of four types of livestock manure and revealed the relationship between the gaseous emissions and microbial communities. Results showed that pig, sheep, and cow manure reached high compost maturity (germination index (GI) > 70%), whereas chicken manure had higher phytotoxicity (GI = 0.

Effects of cornstalk and sawdust coverings on greenhouse gas emissions during sheep manure storage.

Manure covered by organic materials during the storage has shown that it can effectively reduce emissions of greenhouse gases, but few studies have focused on the bacterial communities in manure or the coverage and mechanism responsible for reducing gas emissions. Therefore, this study investigated the impacts and mechanisms of cornstalk and sawdust coverings on greenhouse gas emissions during sheep manure storage. Sheep manure covered by organic material reduced nitrous oxide (NO) emissions (42.

Identification and Validation of Ferroptosis-Related LncRNAs Signature as a Novel Prognostic Model for Chronic Lymphocytic Leukemia.

Background: Chronic lymphocytic leukemia (CLL) is a subtype of B-cell malignancy with high heterogeneity. Ferroptosis is a novel cell death induced by iron and lipid peroxidation and exhibits prognostic value in many cancers. Emerging studies on long non-coding RNAs (lncRNAs) and ferroptosis reveal the unique value in tumorigenesis.

Prognostic value and therapeutic targeting of XPO1 in chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) is a subtype of B-cell malignancy with high heterogeneity. XPO1 is highly expressed in many hematological malignancies, which predicts poor prognosis. In the study, we aimed to explore the prognostic role of XPO1 and the therapeutic effect of Selinexor, a selective inhibitor of nuclear export, which targets XPO1.

Multi-omics analysis provides insight into the phytotoxicity of chicken manure and cornstalk on seed germination.

To minimize environmental risks and the phytotoxic influence of organic materials on crop growth, it is necessary to test their phytotoxicity and maturity when they were used in farmland. However, the stress response of seed germination to chicken manure and cornstalks is not clear. This study used multi-omics analysis to investigate the inhibition mechanism of seed germination by chicken manure and cornstalk.

Phytotoxicity of farm livestock manures in facultative heap composting using the seed germination index as indicator.

Static facultative heap composting of animal manure is widely used in China, but there is almost no systematic research on the phytotoxicity of the produced compost. Here, we evaluated the phytotoxic variation in compost produced by facultative heap composting of four types of animal manure (chicken manure, pig manure, sheep manure, and cattle manure) using different plant seeds (cucumber, radish, Chinese cabbage, and oilseed rape) to determine germination index (GI). The key factors that affected GI values were identified, including the dynamics of the phytotoxicity and microbial community during heap composting.

Identifying a novel ferroptosis-related prognostic score for predicting prognosis in chronic lymphocytic leukemia.

Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Although the treatment landscape for CLL is rapidly evolving, there are still some patients who develop drug resistance or disease refractory. Ferroptosis is a type of lipid peroxidation-induced cell death and has been suggested to have prognostic value in several cancers.

Effects of phosphate-containing additives and zeolite on maturity and heavy metal passivation during pig manure composting.

This study investigated the effects of the combination of phosphogypsum with calcium oxide (PPG + CaO), superphosphate with calcium oxide (SSP + CaO) and zeolite (Zeolite) on composting maturity and heavy metal passivation in pig manure composting. The results showed that all treatments reached the maturity requirements and the phosphorus-containing additive treatments had higher final germination indices (GIs). Compared with CK, additive treatments enhanced the compost maturity by promoting volatile fatty acids (VFAs) decomposition (26.

Composting temperature directly affects the removal of antibiotic resistance genes and mobile genetic elements in livestock manure.

The high antibiotic resistance gene (ARGs) contents in livestock manure pose a potential risk to environment and human health. The heap composting with an ambient temperature and thermophilic composting are two methods for converting livestock manure into fertilizer. This study investigated the variations in ARGs and mobile genetic elements (MGEs) and revealed potential mechanisms for ARGs removal using the two composting methods.

Superphosphate, biochar, and a microbial inoculum regulate phytotoxicity and humification during chicken manure composting.

The germination index (GI) is the best index for evaluating compost phytotoxicity and maturity. In order to improve GI and reduce phytotoxicity of chicken manure compost, superphosphate, biochar, and a microbial inoculum were added in this study. Maturity indices (pH, electrical conductivity, and GI), water-soluble ion, organic matter, humic acid, humic precursor contents, and the bacteria community were analyzed during the experiment.

Impact of biochar, calcium magnesium phosphate fertilizer and spent mushroom substrate on humification and heavy metal passivation during composting.

The effects of exogenous additives (biochar, calcium magnesium phosphate fertilizer, and spent mushroom substrate) on humification process and heavy metal passivation during pig manure composting were investigated. The aerobic composting trial were carried out in 60 L reactors for 49 d. The calcium magnesium phosphate fertilizer, biochar, and spent mushroom substrate amendment treatments all accelerated the organic matter degradation and increased the temperature, decreased the volatile fatty acid content by 45%-49.

Selection of sensitive seeds for evaluation of compost maturity with the seed germination index.

The seed germination index (GI) is a widely used indicator of compost maturity and is a required index in many national standards. However, seeds of different species vary markedly in sensitivity to the biological toxicity of compost. Therefore, suitable seed selection is essential for evaluation of compost maturity with the GI.

Key factors affecting seed germination in phytotoxicity tests during sheep manure composting with carbon additives.

The germination index (GI) was widely applied to evaluate the phytotoxicity of compost. This study investigated the key phytotoxicity factors affecting seed germination in compost by using aqueous extracts in seed germination tests. The relationship between water-soluble substances in compost and seed germination, and their association with the microbial community were identified.

Iron-catalyzed cascade reaction of C(sp)-Se bond cross-coupling/C-N bond formation.

An iron-catalyzed cascade reaction of C(sp3)-Se bond cross-coupling/C-N bond formation was developed. Various 5,13a-dihydro-6H,8H-benzo[5,6][1,3]selenazino[2,3-a]isoquinolin-8-one derivatives were synthesized under mild conditions starting from 1,2,3,4-tetrahydroisoquinolines and 2-hydroselenobenzoic acids. This protocol provides an economical approach for C(sp3)-Se bond formation.

Rectum Protection by Rectal Gel Injection in Cervical Cancer Brachytherapy: A Dosimetric Study Deformable Surface Dose Accumulation and Machine-Learning-Based Discriminative Modeling.

Purpose: This retrospective study aimed to evaluate the dosimetric effects of a rectal insertion of on rectal protection using deformable dose accumulation and machine learning-based discriminative modelling.

Materials And Methods: Sixty-two patients with cervical cancer enrolled in a clinical trial, who received a injection of 20 g into their rectum for rectal protection high-dose rate brachytherapy (HDR-BT, 6 Gy/f), were studied. The cumulative equivalent 2-Gy fractional rectal surface dose was deformably summed using an in-house-developed topography-preserved point-matching deformable image registration method.

Circulating low CD4/CD8 ratio is associated with poor prognosis in Waldenstrom macroglobulinemia patients.

Waldenstrom macroglobulinemia (WM) is a rare type of non-Hodgkin lymphoma with great heterogeneity, and the data of peripheral blood T-lymphocyte subsets in WM are limited. This study aimed to investigate the clinical correlation and distribution of circulating T-lymphocyte subsets in newly diagnosed WM patients. We retrospectively searched medical records for 86 newly diagnosed WM patients.

Enrichment of antibiotic resistance genes after sheep manure aerobic heap composting.

In this study, physio-chemical properties, 45 antibiotics, 6 heavy metals, 42 antibiotic resistance genes (ARGs), 3 mobile genetic elements, and the bacterial community structure were investigated to analyze the fate of ARGs during sheep manure aerobic heap composting. Results showed that sheep manure heap composting could produce mature compost. The degradation processes reduced the total antibiotics content by 85%.