Publications by authors named "Yilin Guan"
Dry eye disease (DED), a multifactorial ocular surface disease, is estimated to affect up to 34% of individuals over 50 years old. Although numerous animal models, including rodents and rabbits, have been developed to mimic the pathophysiologic mechanisms involved in dry eye, there is a lack of non-human primate (NHP) models, critical for translational drug studies. Here, we developed a novel desiccating stress-induced dry eye disease model using Rhesus macaque monkeys.
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- * The study found that MSCs express high levels of CD80, which plays a crucial role in increasing the expression of FoxP3 in Tregs, necessary for their function, in a contact-dependent way.
- * When CD80 was silenced in MSCs, their ability to promote Treg activity and corneal transplant survival was significantly reduced, indicating the importance of CD80 in this process.
Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis.
Cancer Manag Res
June 2020
Background: Glioma is a common malignant tumor worldwide. Sevoflurane (Sev) has been reported to inhibit the metastasis of glioma cells, but the underlying molecular mechanism needs further exploration.
Methods: Cell Counting Kit-8 (CCK8) assay was used to check cell viability.