Construction of ceRNA regulatory networks for osteoporosis.

Osteoporosis increases the risk of fracture. Improving the diagnosis and treatment of osteoporosis has clinical applications. The differentially expressed genes (DEcircRs, DEmRs, DEmiRs) of osteoporotic patients and controls were analyzed using the GEO database, and enrichment analysis of DEmRs was performed.

Dose-Effectiveness Relationships Determining the Efficacy of Ibandronate for Management of Osteoporosis: A Meta-Analysis.

The purpose of this study was to perform a meta-analysis on the efficacy of ibandronate by evaluating the effect sizes of different dosing regimens.Major electronic databases were searched from 1985 to February 2015. A random effects meta-analysis was performed in STATA.

Factors influencing the tensile strength of repaired Achilles tendon: a biomechanical experiment study.

Background: Operative treatment has been advocated as the method of choice to repair Achilles tendon rupture as surgery results in reduced re-rupture rate and faster rehabilitation. Many surgical techniques have been introduced allowing for postoperative early motion of the ankle joint. However, it is currently very difficult for surgeons to determine the optimal treatment conditions for ruptured Achilles tendon with an increasing number of end-to-end suture methods, suture materials, and epitenon suture techniques.

Location of the Hill-Sachs lesion in shoulders with recurrent anterior dislocation.

Introduction: Computed tomography images of 35 shoulders of 34 patients with recurrent anterior dislocation and 13 shoulders of 13 healthy normal volunteers were used to determine the location of the Hill-Sachs lesion in reference to the location of the bare area using computed tomography.

Method: We measured the location, and size of the Hill-Sachs lesion and the bare area, and described them on a clock face on the humeral head.

Results: The Hill-Sachs lesion was observed in slices between 0-3 and 22-24 mm distal from the top of the humeral head.

Effect of an anterior glenoid defect on anterior shoulder stability: a cadaveric study.

Background: There have been few biomechanical studies to clarify which size of a glenoid defect is critical. However, those studies have assumed that the defect occurred anteroinferiorly. Recent studies have reported that the defect is located anteriorly rather than anteroinferiorly.

Glenohumeral joint motion after medial shift of the attachment site of the supraspinatus tendon: a cadaveric study.

During a rotator cuff repair, it is ideal to reattach the torn edge of the cuff tendon back to the greater tuberosity. However, with massive tears where the torn edges are too retracted to be reattached to the greater tuberosity, they may have to be reattached somewhere more medial. It is clinically important to know how far medially one can shift the reattachment site without sacrificing function of the shoulder.

Effect of rotator interval closure on glenohumeral stability and motion: a cadaveric study.

The effect of rotator interval closure, which is performed as an adjunct to arthroscopic stabilization of the shoulder, has not been clarified. Fourteen fresh-frozen cadaveric shoulders were used. The position of the humeral head was measured using an electromagnetic tracking device with the capsule intact, sectioned, and imbricated between the superior glenohumeral ligament and the subscapularis tendon (SGHL/SSC closure) or between the superior and middle glenohumeral ligaments (SGHL/MGHL closure).

Expression of growth factors in the early phase of supraspinatus tendon healing in rabbits.

Growth factors are known to appear during wound healing. We hypothesized that growth factors would also appear during the healing process of a rotator cuff tear. We determined the expression of various growth factors during healing of acute rotator cuff tears in the rabbit.

The effect of the inferior capsular shift on shoulder intra-articular pressure: a cadaveric study.

Background: The inferior capsular shift procedure is commonly performed for multidirectional instability of the shoulder with excellent clinical results.

Hypothesis: The mechanism of this procedure is to increase shoulder stability by changing the responsiveness of intra-articular pressure to downward loading.

Study Design: Controlled laboratory study.

Anterior dislocation after total knee arthroplasty: a case report.

We report a case of anterior dislocation of an 11-year-old total knee arthroplasty in a 52-year-old woman with severe rheumatoid arthritis and osteoporosis. It was noteworthy that the mechanism of dislocation was unique in that massive wear of ultra-high-molecular-weight polyethylene, avulsion injuries of the medial collateral ligament and patellar tendon, and a stress fracture of the fibula secondary to the increased posterior tilt angle eventually caused anterior dislocation of the left knee without obvious trauma or infection.

Attachment types of the long head of the biceps tendon to the glenoid labrum and their relationships with the glenohumeral ligaments.

Purpose: To clarify the attachment types of the long head of the biceps tendon to the glenoid labrum and their relationships with the glenoid attachment of the glenohumeral ligaments. TYPES OF STUDY: Anatomic study in cadavers.

Methods: Using 101 cadaver shoulders, the glenoid attachment types of the biceps tendon and the location of the glenoid origin of the glenohumeral ligaments were assessed macroscopically and then histologically on the sagittal section.

Cross-sectional area of the tendon and the muscle of the biceps brachii in shoulders with rotator cuff tears: a study of 14 cadaveric shoulders.

Background: The intraarticular portion of the long head of the biceps tendon is often widened in shoulders with cuff tears. It is unclear whether this is a local phenomen or is caused by muscle hypertrophy.

Methods: We investigated morphological changes of the biceps brachii in 14 embalmed shoulders: 7 with intact rotator cuff and 7 with rotator cuff tears.

Apoptosis in the supraspinatus tendon with stage II subacromial impingement.

The purpose of this study was to investigate the histopathology, including apoptosis, in the supraspinatus tendon with stage II subacromial impingement. Samples from the critical zone of the supraspinatus tendon were obtained from 5 patients with subacromial impingement syndrome and 10 autopsy cases without shoulder diseases as controls. Three-micrometer-thick sections were cut and stained with hematoxylin-eosin (H-E) for routine histologic examination.

Contact area, contact pressure, and pressure patterns of the tendon-bone interface after rotator cuff repair.

Background: The contact pressure and contact area at the tendon-bone interface after the most commonly used rotator cuff repair methods have not been investigated.

Hypothesis: There are no significant differences among the transosseous, the single-row suture anchor, and the double-row suture anchor techniques in terms of contact pressure, contact area, and pressure patterns at the tendon-bone interface.

Study Design: Controlled laboratory study.

Location of the glenoid defect in shoulders with recurrent anterior dislocation.

Background: In patients with recurrent anterior dislocations of the shoulder, it is well known that the glenoid rim is often deficient (8%-95%). However, little is known regarding the precise location of the bony defect of the glenoid.

Hypothesis: The bony defect is anterior rather than anteroinferior to the glenoid.

Quantitative assessment of thinning of the subscapularis tendon in recurrent anterior dislocation of the shoulder by use of magnetic resonance imaging.

It is known that thinning and lengthening of the subscapularis tendon occur in shoulders with recurrent anterior dislocation. However, no studies have been performed to quantify the morphologic changes of the subscapularis tendon under such conditions. We retrospectively measured the thickness and cross-sectional area of the subscapularis tendon by use of magnetic resonance imaging in 22 shoulders in 11 patients with unilateral recurrent anterior dislocation of the shoulder.

Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases.

Objective: To clarify the clinical and magnetic resonance (MR) imaging features of a rare condition of metastasis of carcinoma to skeletal muscle.

Method: Clinicopathological findings for 12 patients (10 male, two female, age range 48-89 years, mean age 68 years) with skeletal muscle metastases of carcinomas were reviewed retrospectively.

Results: In nine of the 12 patients the skeletal muscle metastasis was presented as "painful mass".

Unusual variant of liposarcoma with multiple punctate calcifications.

We report a case of liposarcoma in a 17-year-old boy in which both the radiographs and histology demonstrated multiple punctate calcifications. In addition, this unusual variant consisting of myxoid, round cell and well-differentiated liposarcoma behaved aggressively resulting in the death of the patient.