Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 10 genome copies per ml plasma, SIV) but not in macaques with low viral loads (< 10, SIV). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIV macaques.
View Article and Find Full Text PDFThe persistence of cells latently infected with HIV-1, named the latent reservoir, is the major barrier to HIV-1 eradication, and the formation and maintenance of the latent reservoir might be exacerbated by activation of the immunoinhibitory pathway and dysfunction of CD8 T cells during HIV-1 infection. Our previous findings demonstrated that prophylactic vaccination combined with PD-1 blockade generated distinct immune response profiles and conferred effective control of highly pathogenic SIV infection in rhesus macaques. However, to our surprise, herein we found that a therapeutic vaccination in combination with PD-1 blockade resulted in activation of the viral reservoir, faster viral rebound after treatment interruption, accelerated AIDS progression, and, ultimately, death in chronically SIV-infected macaques after antiretroviral therapy (ART) interruption.
View Article and Find Full Text PDFWater and energy consumptions in the residential sector are highly correlated. A better understanding of the correlation would help save both water and energy, for example, through technological innovations, management and policies. Recently, there is an increasing need for a higher spatiotemporal resolution in the analysis and modelling of water-energy demand, as the results would be more useful for policy analysis and infrastructure planning in both water and energy systems.
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