Towards Semantically-Consistent Deformable 2D-3D Registration for 3D Craniofacial Structure Estimation from A Single-View Lateral Cephalometric Radiograph.

The deep neural networks combined with the statistical shape model have enabled efficient deformable 2D-3D registration and recovery of 3D anatomical structures from a single radiograph. However, the recovered volumetric image tends to lack the volumetric fidelity of fine-grained anatomical structures and explicit consideration of cross-dimensional semantic correspondence. In this paper, we introduce a simple but effective solution for semantically-consistent deformable 2D-3D registration and detailed volumetric image recovery by inferring a voxel-wise registration field between the cone-beam computed tomography and a single lateral cephalometric radiograph (LC).

CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma.

Hepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages.

Integrative Evaluation of the Clinical Significance Underlying Protein Arginine Methyltransferases in Hepatocellular Carcinoma.

HCC is a major contributor to cancer-related mortality worldwide. Curative treatments are available for a minority of patients diagnosed at early stages; however, only a few multikinase inhibitors are available and are marginally effective in advanced cases, highlighting the need for novel therapeutic targets. One potential target is the protein arginine methyltransferase, which catalyzes various forms of arginine methylation and is often overexpressed in various cancers.

Reconstruction of the coronoid process with the olecranon tip for chronic elbow dislocation in children: A rare case report and literature review.

The coronoid process of the ulna, as a key part of the elbow joint, plays an important role in maintaining elbow joint stability. Reconstruction of the coronoid process is necessary in both acute and chronic coronoid defects to restore elbow stability and avoid early joint degeneration. The olecranon tip may be a useful autologous osteochondral graft for reconstructing the same shape of the ulna coronoid process.

Entanglement entropy and edge modes in topological string theory. Part I. Generalized entropy for closed strings.

Progress in identifying the bulk microstate interpretation of the Ryu-Takayanagi formula requires understanding how to define entanglement entropy in the bulk closed string theory. Unfortunately, entanglement and Hilbert space factorization remains poorly understood in string theory. As a toy model for AdS/CFT, we study the entanglement entropy of closed strings in the topological A-model in the context of Gopakumar-Vafa duality.

Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair.

Purpose: Insufficient biological activity heavily restricts the application and development of biodegradable bone implants. Functional modification of bone implants is critical to improve osseointegration and bone regeneration.

Methods: In this study, L-lysine functionalized graphene oxide (Lys-g-GO) nanoparticles and polydopamine-assisted gold nanoparticle (AuNPs-PDA) coatings were applied to improve the biological function of PLGA scaffold materials.

First case of forearm crisscross injury in children: A case report.

Background: Forearm crisscross injury is rare in children; there is no relevant literature so far. Surgeons lack experience and knowledge in treating this type of crisscross injury. We report a case of forearm crisscross injury in a child for the first time and analyze its mechanism.

Discovery and function exploration of microRNA-155 as a molecular biomarker for early detection of breast cancer.

Background: MicroRNA-155 (miR-155) may function as a diagnostic biomarker of breast cancer (BC). Nevertheless, the available evidence is controversial. Therefore, we performed this study to summarize the global predicting role of miR-155 for early detection of BC and preliminarily explore the functional roles of miR-155 in BC.

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal miR-25 Regulates the Ubiquitination and Degradation of Runx2 by SMURF1 to Promote Fracture Healing in Mice.

Recent evidence has demonstrated that mesenchymal stem cells (MSCs) can release a large number of functionally specific microRNA (miRNA) microvesicles that play a role in promoting osteogenic differentiation, but the specific mechanism is not yet clear. Under such context, this study aims to elucidate the mechanism of bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exo) promoting fracture healing in mice. We isolated and identified the BMSC-Exo.

Combined navigated drilling and arthroscopy facilitate minimally invasive surgical treatment of ulnar-radial joint dislocation caused by epiphyseal premature closure: A case report.

Rationale: In this paper, the efficacy and safety of using navigated drilling and arthroscopy (NDA) to assist surgery for ulnar-radial joint dislocation caused by epiphyseal premature closure (EPC) are described. Deformity correction surgery was mentioned in the literature, but there were numerous complications, for example, poor correction, infection, neurovascular injury, osteofascial compartment syndrome, failure of internal fixation, and nonunion after osteotomy. In order to minimize surgical complications, we utilized navigated drilling to finish accuracy bone bridge resection and applied arthroscopy to assess wrist lesions.

Technology of percutaneous cannulated screw implantation using screw view model of navigation in Garden type I of femoral neck fracture: A case report.

Rationale: The aim of the present study was to assess the efficacy and safety of percutaneous cannulated screw (PCS) implantation assisted by screw view model of navigation (SVMN) to treat femoral neck fracture (FNF).

Patient Concerns: A 42-year-old male patient suffered from a high falling injury, causing pain, swelling, deformity, and limited mobility on his right hip.

Diagnoses: He was diagnosed with Garden type I of FNF.

Lateral optical force on paired chiral nanoparticles in linearly polarized plane waves.

We demonstrate that a lateral optical force (LOF) can be induced on paired chiral nanoparticles with opposite handedness under the illumination of a linearly polarized plane wave. The LOFs on both chiral particles are equal and thus can move the pair sideways, with the direction depending on the separation between two particles, as well as the handedness of particle chirality. Analytical theory reveals that the LOF comes largely from the optical potential gradient established by the multiple scattering of light between the paired particles with asymmetric chirality.

Unilateral multilevel interlaminar fenestration: a minimally invasive approach for cervical intramedullary lesions.

The traditional approach for cervical intramedullary lesions is laminectomy, but the procedure may result in spinal instability and spinal deformity. Unilateral multilevel interlaminar fenestration (UMIF) is an alternative minimally invasive approach that may have great advantages in preserving spinal stability. However its use in cervical intramedullary lesions is rare, and the indications, safety and limitations of this approach for cervical intramedullary lesions are still under investigation.

Surgery for primary filum terminale ependymomas: outcome and prognostic factors.

Introduction: Primary filum terminale ependymoma (PFTE) is a unique type of ependymomas and locates on extramedullary site. However, the clinical features and prognostic factors of PFTE are still unknown due to its rarity.

Aim: This study aimed to evaluate the clinical features, outcomes, and prognostic factors of PFTE in the largest series of cases.

Biomechanical comparison of laminectomy, hemilaminectomy and a new minimally invasive approach in the surgical treatment of multilevel cervical intradural tumour: a finite element analysis.

Purpose: The objective of this study was to investigate the impact of the less invasive procedures of hemilaminectomy and unilateral multilevel interlaminar fenestration (UMIF) on the cervical spinal biomechanics.

Methods: A validated nonlinear finite element model of the intact cervical spine (C2-C7) was modified to study the biomechanical changes as a result of surgical alteration for treatment of intradural tumours at C3-6 using multilevel laminectomy (ML), multilevel hemilaminectomy (MHL) and UMIF with or without unilateral graded facetectomy.

Results: Under the load-controlled method, the greatest biomechanical changes occurred at the surgical segments.