Publications by authors named "Yikui Liu"
Intracerebral hemorrhage (ICH) is a severe subtype of stroke linked to high morbidity and mortality rates. However, the underlying mechanisms of neuronal injury post-ICH remain poorly understood. In this study, we investigated sphingolipid metabolism alterations in neurons using lipidomics and explored the regulatory mechanisms involved.
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- Recent studies show that oxidative stress from intracerebral hemorrhage (ICH) damages neurons and disrupts cell functions, but the mechanisms for maintaining neuronal stability are not fully understood.
- Research using metabolomics, RNA sequencing, and CUT&Tag-seq explored how the PERK/ATF4 pathway related to endoplasmic reticulum stress interacts with mitochondrial one-carbon metabolism in neurons.
- The results indicate that the interaction between GRP78, PERK, ATF4, and mitochondrial one-carbon metabolism is crucial for neuron stability post-ICH, suggesting potential new treatments by modifying these pathways or providing additional NADPH.
A New Classification of Anterior Choroidal Artery Aneurysms and Its Clinical Application.
Front Aging Neurosci
March 2021
The aim of this study was to compare the different subtypes of anterior choroidal artery (AChoA) aneurysm based on a new classification and to analyze the risk factors according to individual endovascular treatment (EVT). In the new classification, AChoA aneurysms are classified into independent type (I type) and dependent type (II type) based on the relationship between the AChoA and the aneurysm. II type aneurysms have three subtypes, IIa (neck), IIb (body), and IIc (direct).
View Article and Find Full Text PDFLong term follow-up and outcomes in adult patients with thalamic gliomas.
Clin Neurol Neurosurg
August 2020
Objectives: To investigate the optimal treatment and prognosis of thalamic glioma in adult patients.
Patients And Methods: We retrospectively analyzed the adult patients with thalamic glioma admitted to our hospital from May 2005 to September 2016. Patients were divided into two groups according to their treatment: surgery-based combined treatment and intensity modulated radiation therapy (IMRT)-based treatment.
Background: Meningioma, a neoplasm of the meninges, is usually a benign localized tumor. Extraneural metastasis is an extremely rare complication of meningiomas, and only a few cases have been reported to date. The present study reports a case of scalp metastasis of an atypical meningioma and discusses the types of atypical meningiomas and their management options.
View Article and Find Full Text PDFObjective: This study aimed to investigate the selection, safety, and prognosis of medial (transcorpus callosal) and lateral (translateral brain gyrus) approaches for adult thalamic glioma resection.
Methods: The medical records of adult patients with thalamic glioma between March 2006 and March 2016 in Huashan Hospital were reviewed. The probabilistic map of the gliomas was shown in Montreal Neurological Institute (MNI) space, and a paralleling midline was delineated to decide the approach.
Objective: Thalamic glioma is a type of midline glioma with poor outcomes. In the present study, we investigated the clinical and molecular features of thalamic gliomas in Chinese patients.
Methods: The data from 26 patients with thalamic glioma who had undergone surgery at Shanghai Huashan Hospital from January 2011 to August 2015 were retrospectively analyzed.