Analysis of Mutations in Dihydropteroate Synthase and Dihydropteroate Reductase Genes Among Non-HIV Patients in China.

Purpose: pneumonia (PJP) shows a high fatality rate in non-HIV patients. However, there are limited data on drug resistance-related gene mutations in these patients. This study aimed to describe the prevalence of mutations in the dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) genes of in non-HIV patients in China, providing a reference for drug usage.

[Effects of Chromium Pollution on Soil Bacterial Community Structure and Assembly Processes].

With the rapid development of industry, chromium (Cr) has become one of the main soil heavy metal pollutants in China, seriously affecting the soil ecological environment and health of residents. In this study, contaminated soil samples were taken around the tannery sludge yard area in Heibei Province. The Illumina MiSeq high-throughput sequencing technology was employed to analyze the structure and assembly processes of soil bacterial communities at different pollution levels.

[Clinical features of imported schistosomiasis mansoni in Beijing City：a report of 6 cases].

Objective: To analyze the clinical features of 6 patients with imported schistosomiasis mansoni, including the epidemic history, clinical manifestations, laboratory tests and therapeutic effect, so as to provide references for improving the levels of diagnosis and treatment of physicians.

Methods: The clinical data of 6 patients with imported schistosomiasis mansoni from January 2009 to July 2016 were collected and analyzed.

Results: All the 6 imported patients with schistosomiasis mansoni had a clear history of cercarial infested water exposure.

[An epidemiologic study on Pneumocystis pneumonia in non-HIV infected patients in China].

Objective: To analyze the epidemiologic features of Pneumocystis pneumonia (PCP) among non-HIV infected patients in China.

Methods: Sputum or bronchoalveolar lavage fluid (BALF) specimens obtained from 851 pneumonia patients without HIV infection from Jan. 2006 to Oct.

Screening Pneumocystis carinii pneumonia in non-HIV-infected immunocompromised patients using polymerase chain reaction.

We evaluated the clinical value of polymerase chain reaction (PCR) for screening Pneumocystis carinii pneumonia (PCP) in non-HIV-infected immunocompromised patients. We retrospectively analyzed PCR and Grocott's methenamine silver (GMS) staining on 1044 clinical specimens obtained from 756 patients. Positive rates of PCR and GMS staining in sputum specimens were 21.

[Continuous axenic cultivation of Pneumocystis carinii isolated from the bronchoalveolar lavage fluid of infected rat].

Objective: To establish axenic cultivation of Pneumocystis carinii (P.c).

Methods: The organisms of P.