Serum CD44 levels in early pregnancy and its genetic variants for increased risk of gestational diabetes mellitus in Chinese pregnant women.

This study aimed to explore associations of serum cluster of differentiation 44 (CD44) levels and its genetic variants in early pregnancy with gestational diabetes mellitus (GDM). We conducted a 1:1 case-control study (n = 414) nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in Tianjin, China. Blood samples were collected at the first antenatal care visit (at a median of 10 gestational week).

Interactive effects of gestational diabetes and high pre-pregnancy body mass index on adverse growth patterns of offspring.

Aims: To examine the independent and interactive effects of maternal gestational diabetes mellitus (GDM) and high pre-pregnancy body mass index (BMI) on the risk of offspring adverse growth patterns.

Materials And Methods: One thousand six hundred and eighty one mother-child pairs were followed for 8 years in Tianjin, China. Group-based trajectory modelling was used to identify offspring growth patterns.

Early prenatal exposure to air pollutants and congenital heart disease: a nested case-control study.

Background: Congenital heart disease (CHD) is one of the most common congenital malformations in humans. Inconsistent results emerged in the existed studies on associations between air pollution and congenital heart disease. The purpose of this study was to evaluate the association of gestational exposure to air pollutants with congenital heart disease, and to explore the critical exposure windows for congenital heart disease.

Maternal insulin resistance and maternal β-cell function during pregnancy for offspring overweight before 2 years of age among women with gestational diabetes.

Objective: To explore associations of maternal insulin resistance and β-cell dysfunction with offspring overweight before 24 months of age among children of Chinese women with gestational diabetes mellitus (GDM).

Methods: Offspring of women with GDM (n = 901) who were enrolled in a lifestyle trial during pregnancy were followed up to 24 months of age in Tianjin, China. Restricted cubic spline analysis was performed to examine full-range associations of maternal homeostatic model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-%β) with childhood overweight.

The association between breastfeeding and childhood obesity/underweight: a population-based birth cohort study with repeated measured data.

Background: The impact of breastfeeding on childhood obesity has long been under debate, with most research showing significant association, and others showing weak or no association between breastfeeding and childhood obesity. What's more, almost all of the previous studies focused on the association between breastfeeding and childhood obesity, and no studies have assessed the association between breastfeeding and childhood underweight. This study aimed to examine the association between breastfeeding and childhood obesity as well as childhood underweight from 1 to 6 years old.

Abnormal glucose in pre-school children and the association with obesity/physical activity: A large population-based study.

Aim: The rise of diabetes mellitus (DM) and impaired fasting glucose (IFG) in children has become a worldwide challenge, but population-based survey targeted on pre-school children is lacking. The aim of the study was to determine the prevalence of DM and IFG in pre-school children and their association with obesity and susceptible behaviours.

Methods: A population-based survey was conducted and 21,571 Chinese children aged 5-6 years were recruited from 66 kindergartens in Tianjin, China during the year of 2016-2018.

Childhood Hyperlipidemia and its Association with Early Growth Among Full-Term-Born Children at 5 to 6 Years of Age in China.

Objective: This study's aim was to assess the prevalence of hyperlipidemia and its association with birth weight and BMI at 2 years of age and 5 to 6 years of age in full-term-born children.

Methods: A population-based, large-scale survey of hyperlipidemia was conducted. Information on 12,701 children aged 5 to 6 years was retrospectively collected from electronic health care records.

Breastfeeding and childhood obesity: A 12-country study.

This study aimed to examine the association between breastfeeding and childhood obesity. A multinational cross-sectional study of 4,740 children aged 9-11 years was conducted from 12 countries. Infant breastfeeding was recalled by parents or legal guardians.

Joint associations between weekday and weekend physical activity or sedentary time and childhood obesity.

Objective: To evaluate the single and joint associations of objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary time on week and weekend days with obesity in children from 12 countries across all inhabited continents.

Methods: A multinational, 12-country cross-sectional study of 5779 children aged 9-11 years was conducted. Time spent in MVPA and sedentary behaviors was assessed by waist-worn accelerometry.

Association of early pregnancy body mass index and children's birth weight with risk of being overweight in childhood.

Objectives: To examine the potential effects of mothers' early pregnancy body mass index (BMI) and children's birth weight on childhood overweight/obesity at 1-6 years of age.

Methods: We performed a cohort study in Tianjin, China, using the health care records from the Tianjin maternal and child health care system with 36 719 mother-child pairs from early pregnancy to children at 6 years of age. Logistic regression analyses were used to assess the single and joint associations of maternal early pregnancy BMI and children's birth weight with the risks of children being overweight at 1-6 years of age in multivariable-adjusted models.

Joint association of birth weight and physical activity/sedentary behavior with obesity in children ages 9-11 years from 12 countries.

Objective: To examine the joint association of birth weight and physical activity/sedentary time with childhood obesity in 12 countries.

Methods: A cross-sectional study of 5,088 children aged 9 to 11 years was conducted. Birth weight was recalled by parents or guardians.

Maternal gestational diabetes and childhood obesity at age 9-11: results of a multinational study.

Aims/hypothesis: The aim of this study was to examine the association between maternal gestational diabetes mellitus (GDM) and childhood obesity at age 9-11 years in 12 countries around the world.

Methods: A multinational cross-sectional study of 4740 children aged 9-11 years was conducted. Maternal GDM was diagnosed according to the ADA or WHO criteria.

Fasting and 2-hour plasma glucose, and HbA1c in pregnancy and the postpartum risk of diabetes among Chinese women with gestational diabetes.

Aims: Very few studies have assessed the association of fasting and 2h glucose, and HbA1c during pregnancy with postpartum diabetes risk among women with prior gestational diabetes mellitus (GDM). We assessed the association of fasting glucose, 2h glucose and HbA1c at 26-30 gestational weeks with postpartum diabetes risk among women with prior GDM.

Methods: A cohort study in 1263 GDM women at 1-5 years after delivery was performed.

[Blood-lipid levels of 20 041 kindergarten children aged 3 to 6 in Tianjin].

Objective: To understand the level of blood-lipid and prevalence of dyslipidemia of children aged 3 to 6 in Tianjin, so as to provide evidence for large-scale blood screening strategy and to develop intervention of dyslipidemia and cardiovascular in children.

Methods: 20,041 children aged 3 to 6 from 48 kindergartens were involved in this study, in Tianjin. Peripheral blood was collected from right leech-finger of these children, after fatless breakfast.

[Prevalence and associated factors of school physical violence behaviors among middle school students in Beijing].

Objective: To described the prevalence of school physical violence behaviors and to explore its associated factors among middle school students in Beijing.

Methods: In 2009, a randomly selected cross-sectional survey was conducted among 5718 students in grades 7 to 12 in Beijing. A self-report anonymous questionnaire involving physical violence at school and socio-demographic variables, such as sex, grades, family economic status and family structure, peer relationships, and communication with their parents etc.

[The prevalence of bullying behaviors among urban middle school students in 18 provinces, China].

Objective: To find out the prevalence of bullying behaviors among urban middle school students in China.

Methods: An anonymous questionnaire survey was conducted among middle school students selected by multiply stage cluster random sampling in 18 provinces in China. 187 328 self-administration questionnaires were finished by students from grade 7 to 12 in urban middle school (male, 86,472; female, 91,106), in which 177,578 were valid.