SHEP1 alleviates cardiac ischemia reperfusion injury via targeting G3BP1 to regulate macrophage infiltration and inflammation.

The macrophage-associated inflammation response plays an important role in myocardial ischemia-reperfusion injury (MIRI). SHEP1(SH2 domain-containing Eph receptor-binding protein 1) has been implicated in adhesion and migration of inflammatory cells. However, the role and molecular mechanism of SHEP1 regulating macrophage remains unclear during MIRI.

Direct articulatory observation reveals phoneme recognition performance characteristics of a self-supervised speech model.

Variability in speech pronunciation is widely observed across different linguistic backgrounds, which impacts modern automatic speech recognition performance. Here, we evaluate the performance of a self-supervised speech model in phoneme recognition using direct articulatory evidence. Findings indicate significant differences in phoneme recognition, especially in front vowels, between American English and Indian English speakers.

Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.

Ethnopharmacological Relevance: Leech, as a traditional Chinese medicine for the treatment of blood circulation and blood stasis, was also widely used to cure pulmonary fibrosis in China. In clinical practice, some traditional Chinese medicine preparation such as Shui Zhi Xuan Bi Hua Xian Tang and Shui Zhi Tong Luo Capsule composed of leech, could improve the clinical symptoms and pulmonary function in patients with idiopathic pulmonary fibrosis (IPF). However, the material basis of the leech in the treatment of IPF were not yet clear.

Transcriptome analysis of sugarcane reveals rapid defense response of SES208 to Xanthomonas albilineans in early infection.

Background: Diseases are the major factor affecting the quality and yield of sugarcane during its growth and development. However, our knowledge about the factors regulating disease responses remain limited. The present study focuses on identifying genes regulating transcriptional mechanisms responsible for resistance to leaf scald caused by Xanthomonas albilineans in S.

Variation in compensatory strategies as a function of target constriction degree in post-glossectomy speech.

Individuals who have undergone treatment for oral cancer oftentimes exhibit compensatory behavior in consonant production. This pilot study investigates whether compensatory mechanisms utilized in the production of speech sounds with a given target constriction location vary systematically depending on target manner of articulation. The data reveal that compensatory strategies used to produce target alveolar segments vary systematically as a function of target manner of articulation in subtle yet meaningful ways.

Characteristics of articulatory gestures in stuttered speech: A case study using real-time magnetic resonance imaging.

Introduction: Most of the previous articulatory studies of stuttering have focussed on the fluent speech of people who stutter. However, to better understand what causes the actual moments of stuttering, it is necessary to probe articulatory behaviors during stuttered speech. We examined the supralaryngeal articulatory characteristics of stuttered speech using real-time structural magnetic resonance imaging (RT-MRI).

Transcriptome analyses shed light on floral organ morphogenesis and bract color formation in Bougainvillea.

Background: Bougainvillea is a popular ornamental plant with brilliant color and long flowering periods. It is widely distributed in the tropics and subtropics. The primary ornamental part of the plant is its colorful and unusual bracts, rich in the stable pigment betalain.

Expression profiling of the Dof gene family under abiotic stresses in spinach.

DNA-binding with one finger (Dof) are plant-specific transcription factors involved in numerous pathways of plant development, such as abiotic stresses responses. Although genome-wide analysis of Dof genes has been performed in many species, but these genes in spinach have not been analyzed yet. We performed a genome-wide analysis and characterization of Dof gene family in spinach (Spinacia oleracea L.

sp. nov., isolated from Antarctic tundra soil, and emended descriptions of , , and .

A rod-shaped, yellow-pigmented, Gram-stain-negative, non-motile and aerobic bacterium, designated 7-3A, was isolated from soil from King George Island, maritime Antarctica, and subjected to a polyphasic taxonomic study. Growth occurred at 4-37 °C (optimum, 20°C) and at pH 5.0-9.

Short-Chained Platinum Complex Catalyzed Hydrosilylation under Thermomorphic Conditions: Heterogeneous Phase Separation at Ice Temperature.

Homogeneous catalysts PtCl[5,5'-bis-(-ClCF(CF)CHOCH)-2,2'-bpy] () and PtCl[5,5'-bis-(-HCF(CF)CHOCH)-2,2'-bpy] (), which contained short fluorous chains, were synthesized and used in catalysis of hydrosilylation of alkynes. In these reactions the thermomorphic mode was effectively used to recover these catalysts from the reaction mixture up to eight cycles by taking advantage of heterogeneous phase separation at ice temperature. This kind of catalysis had previously been observed in fluorous catalysts of platinum containing about 50% F-content, but in this work the percentage of F-content is decreased to only about 30%, by which we termed them as "very light fluorous".

SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose-derived mesenchymal stem cells via metabolic switching.

Background: Mesenchymal stem cells (MSCs) have therapeutic potential for multiple ischemic diseases. However, in vitro expansion of MSCs before clinical application leads to metabolic reprogramming from glycolysis to oxidative phosphorylation, drastically impairing their proliferative and therapeutic capacities. This study aimed to define the regulatory effects of Sirtuin 5 (SIRT5) on the proliferative and therapeutic functions of adipose-derived MSCs (ADMSCs) during in vitro expansion.

Dietary Cholesterol Exacerbates Statin-Induced Hepatic Toxicity in Syrian Golden Hamsters and in Patients in an Observational Cohort Study.

Purpose: Statins are inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, which is involved in cholesterol synthesis. The major side effects of statins include muscle- and liver-related toxicity. Muscle toxicity is highly associated with polymorphisms in cytochrome P450 proteins (CYPs), as predicted by pharmacogenomics.

Effects of Anions and pH on the Stability of ZnO Nanorods for Photoelectrochemical Water Splitting.

This work demonstrates the improved stability of zinc oxide nanorods (ZnO NRs) for the photoanode of solar water splitting under voltage biases by the addition of borate or carbonate ions in the aqueous electrolyte with suitable pH ranges. The ZnO NRs prepared by the hydrothermal method are highly active and stable at pH 10.5 in both borate and carbonate buffer solutions, where a photocurrent higher than 99% of the initial value has been preserved after 1 h polarization at 1.