The bsh1 gene of Lactobacillus plantarum AR113 ameliorates liver injury in colitis mice.

The Western diet (WD) leads to hepatic lipid metabolism disorders. Previous studies have shown that the bile salt hydrolase 1 (bsh1) gene of Lactobacillus plantarum AR113 attenuates colitis under WD. In this study, we preliminarily explored how AR113 attenuates the hepatic inflammatory response in colitis mice on the WD.

ABCF1-K430-Lactylation promotes HCC malignant progression via transcriptional activation of HIF1 signaling pathway.

Lysine lactylation plays critical roles in various diseases, including cancer. Our previous study showed that lactylation of non-histone ABCF1 may be involved in hepatocellular carcinoma (HCC) progression. In this study, we evaluated the prognostic value of ABCF1-K430la in HCC using immunohistochemical staining and performed amino acid point mutations, multi-omics crossover, and biochemical experiments to investigate its biological role and underlying mechanism.

Phytochemistry, quality control and biosynthesis in ginseng research from 2021 to 2023: A state-of-the-art review concerning advances and challenges.

L. (Araliaceae) has a long history of medicinal and edible use due to its significant tonifying effects, and ginseng research has been a hot topic in natural products research and food science. In continuation of our recent ginseng review, we highlighted the advances in ginseng research from 2021 to 2023 with 157 citations, which exhibited the increasingly systematic, collaborative, and intelligent characteristics.

Mixed Carboxylate Ligands Bridging Tetra-Pr-Encapsulated Antimonotungstate: Syntheses, Structure, and Catalytic Activity for Imidazoles Synthesis.

Multinuclear Pr-containing antimonotungstate [Pr(HO)WO(mal)(OAc)(αSbWO)] (, mal = malate anion, OAc = acetate anion), bridged by organic carboxylic acid, was synthesized through a one-pot assembly reaction and structurally characterized. is composed of four [αSbWO] fragments fused together by an organic-inorganic hybrid central [Pr(HO)WO(mal)(OAc)] cluster core through 24 μ-O atoms. Notably, the central cluster comprises unprecedented decanuclear Pr(HO)WO jointly decorated by two types of carboxylic acid ligands.

Float solenoid balun for MRI.

Baluns are crucial in MRI RF coils, essential for minimizing common-mode currents, maintaining signal-to-noise ratio, and ensuring patient safety. This paper introduces the innovative float solenoid balun, based on the renowned solenoid cable trap, and conducts a comparative analysis with the widely used float bazooka balun. Leveraging robust inductive coupling between the cable shield and float resonator, the float solenoid balun offers compact dimensions and post-installation adjustability.

Dual-tuned floating solenoid balun for multi-nuclear MRI and MRS.

Common-mode currents can degrade the RF coil performance and introduce potential safety hazards in MRI. Baluns are the standard method to suppress these undesired common-mode currents. Specifically, floating baluns are preferred in many applications because they are removable, allow post-installation adjustment and avoid direct soldering on the cable.

Frequency-independent dual-tuned cable traps for multi-nuclear MRI and MRS.

Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) of non-proton nuclei (X-nuclei) typically require additional proton imaging for anatomical reference and B shimming. Therefore, two RF systems exist, necessitating cable traps to block the unwanted common-mode current at both Larmor frequencies of H and X-nuclei. This study introduces a frequency-independent dual-tuned cable trap that combines a standard solenoid cable trap with a float solenoid trap to independently tune high and low frequencies without compromising performance.

Evaluation of Functional Components of AR495 on Ovariectomy-Induced Osteoporosis in Mice And RAW264.7 Cells.

Osteoporosis is a disease characterized by abnormal bone metabolism, where bone resorption outpaces bone formation. In this study, we investigated the key functional components of AR495 in mitigating ovariectomy (OVX)-induced osteoporosis in mice. The results indicated that both Lactobacillus plantarum AR495 and its fermentation broth significantly reduced urinary calcium and deoxypyridinoline (DPD) levels in the mice.

Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice.

Age-related cardiovascular diseases continue to be important issues that contribute to the societal burden. Unveiling the molecular mechanisms underlying age-related cardiovascular diseases provides novel opportunities to delay aging and facilitate early disease diagnosis and treatment. This study utilized knockout mice lacking melatonin receptors type 1A (MT1) and 1B (MT2).

Revealing Interactions of Gut Microbiota and Metabolite in Confined Environments Using High-Throughput Sequencing and Metabolomic Analysis.

A confined environment is a special kind of extreme working environment, and prolonged exposure to it tends to increase psychological stress and trigger rhythmic disorders, emotional abnormalities and other phenomena, thus seriously affecting work efficiency. However, the mechanisms through which confined environments affect human health remain unclear. Therefore, this study simulates a strictly controlled confined environment and employs integrative multi-omics techniques to analyze the alterations in gut microbiota and metabolites of workers under such conditions.

Reproducible and highly miniaturized bazooka RF Balun using a printed capacitor.

Purpose: There is currently a strong trend in developing RF coils that are high-density, lightweight, and highly flexible. In addition to the resonator structure of the RF coil itself, the balun or cable trap circuit serves as another essential element in the functionality and sensitivity of RF coils. This study explores the development and application of reproducible highly miniaturized baluns in RF coil design.

Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18.

Background: Myocardial hypertrophy is a chronic cardiac condition that often occurs from long-term pressure or volumetric load on the heart. Propranolol hydrochloride has been employed in research on hypertension, pheochromocytoma, myocardial infarction, arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. Current treatments for this condition have side effects, such as arrhythmias and myocardial cell death, thus necessitating safer and more effective alternatives.

Enhanced resistance of Lactiplantibacillus plantarum by expression of albumin.

Background: Human serum albumin (HSA) is the most abundant protein in plasma, playing crucial roles in regulating osmotic pressure and maintaining protein homeostasis. It is widely applied in the clinical treatment of various diseases. HSA can be purified from plasma or produced using recombinant DNA technology.

A Cross Talking between the Gut Microbiota and Metabolites of Participants in a Confined Environment.

Certain workplaces, like deep-sea voyages, subject workers to chronic psychological stress and circadian rhythm disorders due to confined environments and frequent shifts. In this study, participants lived in a strictly controlled confined environment, and we analyzed the effects of a confined environment on gut microbiota and metabolites. The results showed that living in confined environments can significantly alter both the gut microbiota and the gut metabolome, particularly affecting lipid metabolism pathways like glycerophospholipid metabolism.

Who holds the social power? The development of children's social power perceptions in China.

This study examined the development of social power perceptions among Chinese children aged 3-5 years (N = 105). After watching videos about various social power cues, such as resource possession, resource control, goal achievement, permission, giving orders, setting norms and popularity, the children were asked to identify the powerful agents (whom do you believe is the more powerful person?) in the videos and provide explanations (why do you think he (she) is a powerful person?). Three-year-olds can recognize powerful agents who can grant 'permission' to other agents.

Detunable wireless Litzcage coil for human head MRI at 1.5 T.

Inductively coupled radiofrequency (RF) coils are an inexpensive and simple method to realize wireless RF coils in magnetic resonance imaging (MRI), which can significantly ease the MRI scan setup and improve patient comfort because they do not require bulky components such as cables, baluns, preamplifiers, and connectors. However, volume-type wireless coils are typically operated in transmit/receive mode because detuning such coils is much more challenging due to their complex structure and multiple resonant modes. Meanwhile, adding too many detuning circuits to a wireless coil would decrease the coil's quality factor, impair the signal-to-noise ratio, and increase the cost.

Metabolites, flavor profiles and ripening characteristics of Monascus-ripened cheese enhanced by Ligilactobacillus salivarius AR809 as adjunct culture.

Adjunct cultures strongly determined the distinguishing sensorial and nutritional characteristics of cheeses. Metabolites, flavor profiles and ripening characteristics of Monascus-ripened cheese enhanced by the co-fermentation of Ligilactobacillus salivarius AR809 were investigated. The AR809 significantly increased the contents of soluble nitrogen, small peptides (<1200 Da), free amino acids, and casein degradation degree in the resulting cheese.

Effects of different lactic acid bacteria on the characteristic flavor profiles of Chinese rice wine.

Background: It has been well accepted that lactic acid bacteria (LAB) are the main bacterial genera present during the brewing of Chinese rice wine (CRW). LAB plays a decisive role in the flavor quality of CRW; however, its application in CRW has previously been overlooked. Therefore, effects of different LAB as co-fermenter on the flavor characteristics of CRW were investigated.

Establishment of CRISPR-Cas9 system in Bifidobacteria animalis AR668.

Bifidobacteria are representative intestinal probiotics that have extremely high application value in the food and medical fields. However, the lack of molecular biology tools limits the research on functional genes and mechanisms of bifidobacteria. The application of an accurate and efficient CRISPR system to genome engineering can fill the gap in efficient genetic tools for bifidobacteria.

1 Gene of AR113 Plays an Important Role in Ameliorating Western Diet-Aggravated Colitis.

Western diet is thought to increase susceptibility to inflammatory bowel disease (IBD), and probiotics are a potential therapeutic agent for IBD. This study revealed the effects of AR113 and AR113Δ1 on a dextran sulfate sodium (DSS)-induced colitis mouse model under the Western diet (WD). After four weeks of WD and low-sugar and low-fat diet (LD) intervention, induction with 3% DSS, and intragastric administration of probiotics, we found that AR113 could regulate blood glucose and lipid levels and have a certain protective effect on hepatocytes.

Joint Correlation and Attention Based Feature Fusion Network for Accurate Visual Tracking.

Correlation operation and attention mechanism are two popular feature fusion approaches which play an important role in visual object tracking. However, the correlation-based tracking networks are sensitive to location information but loss some context semantics, while the attention-based tracking networks can make full use of rich semantic information but ignore the position distribution of the tracked object. Therefore, in this paper, we propose a novel tracking framework based on joint correlation and attention networks, termed as JCAT, which can effectively combine the advantages of these two complementary feature fusion approaches.

Flavor compounds with high odor activity values (OAV > 1) dominate the aroma of aged Chinese rice wine (Huangjiu) by molecular association.

Aging is an essential operation to perfect the flavor quality of Hungjiu. In this study, formation mechanism of flavor compounds responsible for the characteristic flavor of aged Huangjiu was investigated. The contents of umami and bitter free amino acids (FAA) increased with the storage period prolonged, while that of sweet FAA showed downward trend.

Enhancement of triterpene production via in situ extractive fermentation of Sanghuangporus vaninii YC-1.

There have been many studies on the activities and polysaccharide production of Sanghuangporus vaninii. However, few studies have looked at triterpene production from S. vaninii using liquid-state fermentation.

Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota.

The probiotic has been widely used in colitis treatment; however, the beneficial effects of other yeast species are rarely studied. with great stress tolerance and potential in colitis treatment was investigated in this study. Among 16 yeast strains, BR14, BR54, and BR174 strains showed good stress-resistant capacity, anti-inflammatory activity, and little toxicity to macrophages.