Fluorescence imaging opens a new window for the diagnosis of early-stage Alzheimer's disease.

As the global population ages, the incidence and prevalence of Alzheimer's disease (AD) continues to rise, posing a serious threat to human health. Butyrylcholinesterase (BChE), which is overexpressed in the brains of patients with AD, is a potential drug target and biomarker. However, the molecular mechanism underlying BChE's role in the AD process remains unclear.

Analyzing the differences and correlations between key metabolites and dominant microorganisms in different regions of Daqu based on off-target metabolomics and high-throughput sequencing.

Daqu is usually produced in an open environment, which makes its quality unstable. The microbial community of Daqu largely determines its quality. Therefore, in order to improve the fermentation characteristics of Daqu, samples were collected from Jinsha County (MT1), Xishui County (MT2), and Maotai Town (MT3) in Guizhou Province to explore the microbial diversity of Daqu and its impact on Daqu's metabolites.

Study on the Fermented Grain Characteristics and Volatile Flavor Substances during the Tuqu Fermentation of Hunan Light-Flavor Baijiu.

The present study employed Hunan local Tuqu for fermentation and investigated the physicochemical properties, microbial community composition, and volatile flavor compounds of the fermented grains, as well as the correlation between the physicochemical indicators and the microbial community. The findings reveal that the activities of α-amylase and glucoamylase were highest during the initial stages of the fermentation process. The acid protease activity increased to 30.

DPPX antibody-mediated autoimmune encephalitis：the first case with breast cancer and review of the literature.

Dipeptidyl-peptidase-like protein 6 (DPPX) antibody-mediated encephalitis is a rare type of autoimmune encephalitis (AE), which mainly manifests as diarrhea accompanied by weight loss, cognitive decline, epileptic seizures, and even psychiatric symptoms. Remarkably, it is also reported to be associated with tumors, predominantly B-cell lymphoma. Overall, the AE remains uncharacterized clinically and its long-term prognosis remains elusive.

The association between serum heat shock protein 72 and intestinal permeability with intestinal microbiota and clinical severity in patients with cerebral infarction.

Objectives: We aimed to compare serum heat shock protein 72 (HSP72) and intestinal permeability in patients with cerebral infarction (CI) and healthy individuals to reveal their correlations and link to gut microbiota alterations and clinical severity of CI.

Methods And Results: Stool samples of 50 patients with CI and 46 healthy volunteers were analyzed through 16S rRNA gene sequencing to characterize intestinal flora profiles. Serum HSP72 and zonulin were assayed using enzyme-linked immunoassay (ELISA).

Research advances in cGAS-stimulator of interferon genes pathway and central nervous system diseases: Focus on new therapeutic approaches.

Cyclic GMP-AMP synthase (cGAS), a crucial innate immune sensor, recognizes cytosolic DNA and induces stimulator of interferon genes (STING) to produce type I interferon and other proinflammatory cytokines, thereby mediating innate immune signaling. The cGAS-STING pathway is involved in the regulation of infectious diseases, anti-tumor immunity, and autoimmune diseases; in addition, it plays a key role in the development of central nervous system (CNS) diseases. Therapeutics targeting the modulation of cGAS-STING have promising clinical applications.

Calculation of aberration fields for freeform imaging systems using field-dependent footprints on local tangent planes.

Aberration theory is a fundamental understanding of the optical aberrations and remains the best way to guide optical system design. The nodal aberration theory, which can be used to describe the aberration fields of freeform imaging systems, is limited by the small field of view (FOV) of the imaging system. In this paper, we propose a method to predict the induced aberration of Fringe Zernike terms with field-dependent footprints.

Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.

Plant diseases caused by bacteria have become one of the serious problems that threaten human food security, which led to the remarkable reduction of agricultural yields and economic loss. Nitroreductase (NTR), as an important biomarker, is highly expressed in bacteria, and the level of NTR is closely related to the progression of pathogen infection. Therefore, the design of small-molecule fluorescent sensors targeting NTR is of great significance for the detection and diagnosis of plant pathogenic bacteria.

In vivo fluorescent screening for HPPD-targeted herbicide discovery.

Background: 4-Hydroxyphenylpyruvate dioxygenase (HPPD), playing a critical role in vitamin E and plastoquinone biosynthesis in plants, has been recognized as one of the most important targets for herbicide discovery for over 30 years. Structure-based rational design of HPPD inhibitors has received more and more research interest. However, a critical challenge in the discovery of new HPPD inhibitors is the common inconsistency between molecular-level HPPD-based bioevaluation and the weed control efficiency in fields, due to the unpredictable biological processes of absorption, distribution, metabolism, and excretion.

High-performance imaging with an advanced non-imaging lens based on full-path optical diffraction calculation in two-dimensional space.

High-performance image-forming systems often require high system complexity due to the overdetermined nature of optical aberration correction. What we present here is a novel computational imaging modality which can achieve high-performance imaging using a simple non-image-forming optical system. The presented optical system contains an aspherical non-imaging lens which is designed with the optimal transfer of light radiation between an object and a detector.

A General Grid-Less Design Method for Location and Pressure Sensors with High Precision.

Bionic electronic skin can accurately sense and locate surface pressure, which is widely demanded in many fields. Traditional electronic skin design usually relies on grid-architecture sensor arrays, requiring complex grid and interconnection arrangements as well as high cost. Grid-less planar sensors can solve the problem by using electrodes only at the edges, but they usually require the use of mapping software such as electrical impedance tomography to achieve high precision.

Microbial Diversity and Physicochemical Characteristics of the Maotai-Flavored Liquor Fermentation Process.

The grains fermented in Maotai-flavored liquor can be classified into two groups: high-temperature fermented grains generated by stacking and grains fermented in pits. The Maotai-flavor making process enriches a special microbiota from the fermented grains, which makes related studies more difficult. The use of modern molecular techniques to detect and analyze diversity and changes in total bacterial (16S rRNA sequencing) and fungal (internal transcribed spacer (ITS) sequencing) counts have helped to overcome the shortcomings of traditional technological research.

Efficient green light-excited switches based on dithienylethenes with BF-doped π-conjugated systems.

A series of dithienylethenes 1a-1d with BF-doped π-conjugation have been successfully developed. Upon alternating irradiation with green light and red/NIR light, they show efficient photochromism and fluorescence switching behaviors in toluene and PMMA film. Moreover, the fluorescence of 1a can be switched effectively in living cells.

Blue-/NIR Light-Excited Fluorescence Switch Based on a Carbazole-Dithienylethene-BFbdk Triad.

The development of novel solid-state fluorescence switches, particularly triggered by visible light, is of increasing interest for the potential application in optical data storage and super-resolution fluorescence microscopies. In this study, two carbazole-dithienylethene-BFbdk triads and , suspending carbazole and BFbdk moieties on both sides of dithienylethene unit, have been developed. They exhibit blue-/NIR light-controlled photochromism with solvent-dependent characteristics.