Mechanical Properties of Internally Hierarchical Multiphase Lattices Inspired by Precipitation Strengthening Mechanisms.

In metal metallurgy, precipitation strengthening is widely used to increase material strength by utilizing the impediment effect of the second-phase particles on dislocation movements. Inspired by this mechanism, in this paper, novel multiphase heterogeneous lattice materials are developed with enhanced mechanical properties utilizing a similar hindering effect of second-phase lattice cells on the shear band propagation. For this purpose, biphase and triphase lattice samples are fabricated using high-speed multi jet fusion (MJF) and digital light processing (DLP) additive manufacturing techniques, and a parametric study is carried out to investigate their mechanical properties.

A Telomerase-Activated Magnetic Resonance Imaging Probe for Consecutively Monitoring Tumor Growth Kinetics and Screening Inhibitors.

Telomerase has long been considered as a biomarker for cancer diagnosis and a therapeutic target for drug discovery. Detecting telomerase activity could provide more direct information of tumor progression and response to drug treatment, which, however, is hampered by the lack of an effective probe that can generate an output signal without a tissue penetration depth limit. In this study, using the principle of distance-dependent magnetic resonance tuning, we constructed a telomerase-activated magnetic resonance imaging probe (TAMP) by connecting superparamagnetic ferroferric oxide nanoparticles (SPFONs) and paramagnetic Gd-DOTA (Gd(III) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) complexes via telomerase-responsive DNA motifs.

Improving the ecological environmental performance to achieve carbon neutrality: The application of DPSIR-Improved matter-element extension cloud model.

Ecological environmental issues are global focus problems. Achieving carbon neutrality is a fundamental measure to protect the ecological environment. Government environmental governance plays a key role in the process of moving towards a carbon neutral vision since the externality of the environment.

Bioorthogonal catalytic patch.

Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial chemistry complementary to enzymatic reactions, enabling the selective labelling of biomolecules or in situ synthesis of bioactive agents via non-natural processes. However, the effective deployment of bioorthogonal catalysis in vivo remains challenging, mired by the safety concerns of metal toxicity or complicated procedures to administer catalysts. Here, we describe a bioorthogonal catalytic device comprising a microneedle array patch integrated with Pd nanoparticles deposited on TiO nanosheets.

The physical properties of poly(l-lactide) and functionalized eggshell powder composites.

Aiming at improved crystallization performance and simultaneously enhanced solid-state properties of poly(l-lactide) such as mechanical properties and enzymatic hydrolysis. A novel functionalized eggshell powder decorated with calcium phenylphosphonic acid (NES) was synthesized via the chemical reaction between phenylphosphonic acid and calcium ion on the surface of eggshell powder to form effective nucleating surface for poly(l-lactide). The resultant NES was incorporated into PLLA matrix to form fully biodegradable composites by melt blending, which exhibited superior crystallization, mechanical properties, and enzymatic hydrolysis.