Quantitatively Visualizing Airborne Disease Transmission Risks of Different Exhalation Activities through CO Imaging.

Aerosol transmission has played a leading role in COVID-19 pandemic. However, there is still a poor understanding about how it is transmitted. This work was designed to study the exhaled breath flow dynamics and transmission risks under different exhaling modes.

Discovery and development of tumor glycolysis rate-limiting enzyme inhibitors.

Tumor cells mainly provide necessary energy and substances for rapid cell growth through aerobic perglycolysis rather than oxidative phosphorylation. This phenomenon is called the "Warburg effect". The mechanism of glycolysis in tumor cells is more complicated, which is caused by the comprehensive regulation of multiple factors.

Design, synthesis, and biological evaluation of 3',4',5'-trimethoxy evodiamine derivatives as potential antitumor agents.

A series of compounds bearing 3',4',5'-trimethoxy module into the core structure of evodiamine were designed and synthesized. The synthesized compounds were screened in vitro for their antitumor potential. MTT results showed that compounds 14a-14c and 14i-14j had significant effects, with compound 14h being the most prominent, with an IC value of 3.

Degradation of sulfamethazine by biochar-supported bimetallic oxide/persulfate system in natural water: Performance and reaction mechanism.

The rapid development of aquaculture results in the increased concentrations and kinds of antibiotics in water environment, and the sharply growing antibiotic contamination has caused increasing concerns. Herein, an innovative sulfamethazine (SMT) removal approach was developed by activation of persulfate (PS) using biochar-based materials prepared by co-precipitation and pyrolysis: Fe-Mg oxide/biochar (FeMgO/BC). Experiments on the activation of PS by FeMgO/BC under different factors were carried out.

Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.

5,6,7-Trimethoxy flavonoid salicylate derivatives were designed by the joining of three important pharmacophores (TMP, flavonoid, and SA) according to the combination principle. A series of novel trimethoxy flavonoid salicylate derivatives were synthesized and their in vitro anti-tumor activities were evaluated. Among these derivatives, compound 7f exhibited excellent antiproliferative activity against HGC-27 cells and MGC-803 cells with IC values of 10.