Cost-effectiveness analysis of immune checkpoint inhibitors as first-line therapy in advanced biliary tract cancer.

To assess the cost-effectiveness of immune checkpoint inhibitors as first-line treatments for advanced biliary tract cancer (BTC). This pharmacoeconomic evaluation employed the fractional polynomial network meta-analysis and partitioned survival model. Costs and utilities were collected from the literature and databases.

Effects of natural products on angiogenesis in melanoma.

Melanoma is the most aggressive form of skin cancer and originates from genetic mutations in melanocytes. The disease is multifactorial, but its main cause is overexposure to UV radiation. Currently, available chemotherapy expresses little to no results, which may justify the extensive use of natural products to treat this cancer.

improves energy metabolism in obese hyperglycemic mice.

(CT) improves energy metabolism. However, the role of CT in alleviating obesity-induced hyperglycemia by targeting the liver remains unknown. Therefore, this article aims to explore the mechanism by which CT improves energy metabolism and resists hyperglycemia.

Serotype, antibiotic susceptibility and whole-genome characterization of in all age groups living in Southwest China during 2018-2022.

Background: is a common pathogen that colonizes the human upper respiratory tract, causing high morbidity and mortality worldwide. This study aimed to investigate the prevalence status of isolated from patients of all ages in Southwest China, including serotype, antibiotic susceptibility and other molecular characteristics, to provide a basis for clinical antibiotic usage and vaccine development.

Methods: This study was conducted from January 2018 to March 2022 at West China Hospital, West China Second University Hospital, First People's Hospital of Longquanyi District (West China Longquan Hospital), Meishan Women and Children's Hospital (Alliance Hospital of West China Second University Hospital) and Chengdu Jinjiang Hospital for Women and Children Health.

Study on remediation of cadmium contaminated paddy field by ramie (Boehmeria nivea L.) floating island and its supporting technology.

Ramie (Boehmeria nivea L.) is an ideal crop for cadmium (Cd) pollution remediation due to its advantages of both remediating and utilizing, however, it is mainly carried out in dry land, whose restoration effect is relatively slow. Previously, we found that the ramie plants cultivated by hydroponics has several tens of times higher Cd absorption capacity than that planted in soil.

The food safety assessment of all-female common carp (Cyprinus carpio) (cyp17a1+/-;XX genotype) generated using genome editing technology.

There are several technical challenges and public issues concerning genome editing applications before they become viable in commercial aquaculture. Recently, we developed a novel strategy to generate all-female (AF) common carp, which exhibited a growth advantage over the control carp, using genetic editing through single gene-targeting manipulation. Here, we found that the body weight of the AF common carp was higher by 22.

Effects of Hemolysis on Routine Coagulation Tests when Tested on an Optical Coagulation Analyzer.

Background: The Clinical and Laboratory Standards Institute recommends rejecting hemolyzed samples for coagulation tests. Sysmex CS5100 analyzer using an optical method is commonly used in laboratories. The influence of hemolysis on coagulation test has rarely been studied when tested on Sysmex CS5100.

Menthol: An underestimated anticancer agent.

Menthol, a widely used natural, active compound, has recently been shown to have anticancer activity. Moreover, it has been found to have a promising future in the treatment of various solid tumors. Therefore, using literature from PubMed, EMBASE, Web of Science, Ovid, ScienceDirect, and China National Knowledge Infrastructure databases, the present study reviewed the anticancer activity of menthol and the underlying mechanism.

[Rapid flavonoid-focused sub-chemome characterization of Draconis Sanguis using UPLC-Q-TOF-MS in combination with molecular weight imprinting and mass defect filtering].

Draconis Sanguis is a precious Chinese medicinal material for activating blood and resolving stasis, and its effective components are flavonoids. However, the structural diversity of flavonoids in Draconis Sanguis brings great challenges to the in-depth chara-cterization of its chemical composition profiles. To clarify the substance basis of Draconis Sanguis, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) was used in this study to acquire MS data of Draconis Sanguis.

Effects of slanted bilateral lateral recession conventional bilateral lateral recession on convergence insufficiency intermittent exotropia: a prospective study.

Aim: To observe the surgical effects of slanted bilateral lateral recession (S-BLR) versus conventional bilateral lateral recession (C-BLR) in convergence insufficiency intermittent exotropia (CI-IXT).

Methods: Using a randomized, double-blind, prospective design, 22 patients with CI-IXT who were admitted to Renmin Hospital of Wuhan University from July 2019 to December 2020 were included. Patients were randomly divided into either S-BLR or C-BLR group for their subsequent strabismus surgery.

Automatic emotion regulation prompts response inhibition to angry faces in sub-clinical depression: An ERP study.

The neurocognitive mechanism by which automatic emotion regulation (AER) affects emotion processing remains understudied in the context of psychopathology, such as depression. Participants with sub-clinical depression and healthy controls were randomly assigned to an emotion regulation priming group or a neutral priming group. All participants completed an emotional Go/No-go task by judging the gender of angry or happy faces.

Clinical efficacy of botulinum toxin type A on acute acquired comitant esotropia.

Aim: To investigate the effects of micro-injection of botulinum toxin A (BTXA) on acute acquired comitant esotropia (AACE).

Methods: A total of 33 AACE patients who underwent BTXA micro-injection at Renmin Hospital of Wuhan University from September 1, 2019 to July 1, 2021 were retrospective analyzed. Esotropia, eye alignment, stereopsis, and complications were examined at baseline (except complications), 1wk, 1, 3, and 6mo after injection.

VO-assisted multifunctional metamaterial for polarization conversion and asymmetric transmission.

A VO-assisted temperature-controlled multifunctional metamaterial polarization converter with large asymmetric transmission (AT) is proposed by introducing a gold-VO grating. The converter can be switched between reflection mode and transmission mode by controlling the phase transition. When VO is in the metallic state, the converter works in reflection mode, converting the incident forward/backward linearly/circularly polarized waves into the cross-polarized waves, and the broadband polarization conversion rates (PCRs) can reach 90% with relative bandwidth of up to 91.

The potential application of natural products in cutaneous wound healing: A review of preclinical evidence.

Under normal circumstances, wound healing can be summarized as three processes. These include inflammation, proliferation, and remodeling. The vast majority of wounds heal rapidly; however, a large percentage of nonhealing wounds have still not been studied significantly.

The Effect of Different Treatment Methods on Acute Acquired Concomitant Esotropia.

Objective: The application of botulinum toxin type A (BTXA) in the treatment of paralytic strabismus has been recognized, but there are few studies on the treatment of acute acquired comitant esotropia (AACE). This study was aimed to investigate the clinical characteristics of AACE and compare the therapeutic effects of BTXA and traditional surgery.

Methods: 78 patients with AACE in Renmin Hospital of Wuhan University between March 2019 and March 2021 were reviewed.

[Isomeric discrimination of kaempferol versus luteolin by online energy-resolved mass spectrometry].

Isomers are widely distributed in Chinese herbal medicines,and can be discriminated by energy-resolved mass spectrometry( ER-MS). However,ER-MS was performed through direct injection of reference compounds with syringe pump,which encountered a significant technical barrier for high-throughput and automated measurements. Herein,online ER-MS was conducted using LC-MS platform,and a pair of isomers,kaempferol vs luteolin,were employed as a case study to illustrate and assess the utility of online ER-MS for isomeric discrimination.

Clinical characteristics and aetiology of acute acquired comitant esotropia.

Clinical Relevance: Acute acquired comitant esotropia (AACE) is characterised by the acute onset of diplopia which affects work and life.

Background: To describe the clinical characteristics and discuss the aetiology of acute acquired comitant esotropia.

Methods: The medical records of 51 patients with AACE were retrospectively analysed, and their age, occupation, daily average time spent on near work, angle of deviation, refractive error and aetiology were analysed.

The Effects of Subliminal Goal Priming on Emotional Response Inhibition in Cases of Major Depression.

Previous studies have provided evidence that automatic emotion regulation (AER), which is primed by control goals, can change emotion trajectory unconsciously. However, the cognitive mechanism and associated changes in depression remain unclear. The current study aimed to examine whether subliminal goal priming could change the emotional response inhibition among patients with major depressive disorder (MDD) and their healthy controls.

Long-Distance Continuous-Variable Quantum Key Distribution over 202.81 km of Fiber.

Quantum key distribution provides secure keys resistant to code-breaking quantum computers. The continuous-variable version of quantum key distribution offers the advantages of higher secret key rates in metropolitan areas, as well as the use of standard telecom components that can operate at room temperature. However, the transmission distance of these systems (compared with discrete-variable systems) are currently limited and considered unsuitable for long-distance distribution.

A modified turbulence model for simulating airflow aircraft cabin environment with mixed convection.

Unlabelled: The forced convection (air supply jet) and the natural convection (thermal plume of passenger) co-exist in an aircraft cabin simultaneously. Due to the notable difference of the Reynolds numbers for the two convection processes, the traditional RANS method can hardly simulate the forced/natural convection flows accurately at the same time. In addition, the large geometric ratio between the main air supply inlet and the whole cabin leads to difficulties in grid generation for the cabin space.

Visualizing the prediction of laser cleaning: a dynamic preview method with a multi-scale conditional generative adversarial network.

By producing high power per unit area and obtaining immediate feedback, lasers offer the potential for high-precision surface processing. However, due to having many complex and nonlinear physiochemical processes, unfitted values of parameters can easily result in undesired cleaning results: the substrate is either damaged or not cleaned. Thus, an accurate, flexible, and automatic image preview method is highly demanded in the cleaning practice.

Fluorescence Quenching of a Conjugated Polymer by Synergistic Amine-Carboxylic Acid and π-π Interactions for Selective Detection of Aromatic Amines in Aqueous Solution.

Fluorescence sensing of amine in aqueous solution is challenging. The various basicity and chemical structures of amines may lead to poor selectivity in aqueous solution, and selective fluorescence detection of primary aromatic amine is rarely reported. This paper presents design and synthesis of a fluorescent conjugated polymer for rapid and selective sensing of aromatic amines in aqueous solution.

A novel synonymous SNP in PITX3 is associated with Parkinson's disease in Chinese population.

Background And Purpose: Paired-like homeodomain transcription factor 3 (PITX3) is an important transcription factor for differentiation and survival of dopaminergic neurons. Recent reports have shown a strong association of polymorphisms in the PITX3 gene with Parkinson's disease (PD). Our study was designed to verify whether three previous PITX3 SNPs (rs2281983, rs4919621 and rs3758549) were associated with PD in the Chinese population.

Decentralized Bayesian search using approximate dynamic programming methods.

We consider decentralized Bayesian search problems that involve a team of multiple autonomous agents searching for targets on a network of search points operating under the following constraints: 1) interagent communication is limited; 2) the agents do not have the opportunity to agree in advance on how to resolve equivalent but incompatible strategies; and 3) each agent lacks the ability to control or predict with certainty the actions of the other agents. We formulate the multiagent search-path-planning problem as a decentralized optimal control problem and introduce approximate dynamic heuristics that can be implemented in a decentralized fashion. After establishing some analytical properties of the heuristics, we present computational results for a search problem involving two agents on a 5 x 5 grid.