Protective Role of Cepharanthine Against Equid Herpesvirus Type 8 Through AMPK and Nrf2/HO-1 Pathway Activation.

Equid herpesvirus type 8 (EqHV-8) is known to cause respiratory disease and miscarriage in horses and donkeys, which is a major problem for the equine farming industry. However, there are currently limited vaccines or drugs available to effectively treat EqHV-8 infection. Therefore, it is crucial to develop new antiviral approaches to prevent potential pandemics caused by EqHV-8.

Understanding genetic architecture of breast cancer: how can proteome-wide association studies contribute?

Proteome-wide association studies (PWAS) address gaps in post-transcriptional modifications that previous genome- and transcriptome-wide association studies could not capture. Zhao and colleagues conducted the first breast tissue-based PWAS and identified proteins associated with breast cancer risk, providing insights into the role of protein expression in breast cancer development.

Challenges and Recommendations for Improving Cancer Research and Practice in Nigeria: .

Background: Cancers, with increasing incidence and mortality rates, constitute a leading public health problem in Nigeria. As the burden of cancer in Nigeria increases, research and quality service delivery remain critical strategies for improved cancer control across the continuum of care. This study contextualizes the challenges and gaps in oncology research and practice in Nigeria, and presents recommendations to address the gaps.

Relationship between Thinking Dispositions, Working Memory, and Critical Thinking Ability in Adolescents: A Longitudinal Cross-Lagged Analysis.

Previous studies have demonstrated that thinking dispositions and working memory are closely related to students' critical thinking ability. However, little is known about whether bidirectionality between thinking dispositions, working memory, and critical thinking ability exists in adolescence. This study, therefore, explored this aspect across two time points.

Geographic and Physician-Level Variation in the Use of Hypofractionated Radiation Therapy for Breast Cancer in the U.S.: A Cross-Classified Multilevel Analysis.

Purpose: We aimed to assess geographic and physician-level variation for hypofractionated whole-breast irradiation (HF-WBI) use for early-stage breast cancer patients in the United States. We further evaluated the association between HF-WBI use and demographic factors after accounting for these variations.

Methods And Materials: We performed a retrospective study of early-stage breast cancer patients using private employer-sponsored insurance claims from 2008 to 2017.

Enhancing antibody detection sensitivity in lateral flow immunoassays using endospores of Bacillus subtilis as signal amplifiers.

Antibody detection is the critical first step for tracking the spread of many diseases including COVID-19. Lateral flow immunoassay (LFIA) is the most commonly used method for rapid antibody detection because it is easy-to-use and inexpensive. However, LFIA has limited sensitivity when gold nanoparticles (AuNPs) are used as the signals.

Investigation on the Surface Integrity of 40Cr Steel Machined by Rotary Ultrasonic Flank Milling.

Rotary Ultrasonic Machining (RUM) stands as a crucial method for machining hard and brittle materials. However, for machining hard-to-machine metal, it continues to face many challenges due to the complex vibration of the milling tool. Flank milling is an efficient method for machining complex parts, such as blisks and impellers, which have been widely used in aerospace field.

Self-templated flower-like NiCoZn-carbonate hydroxide hollow nanospheres for asymmetric supercapacitors with high performance.

With the increasing demand for energy resources, it is crucial to explore electrode materials with high specific capacitance and cycling stability for supercapacitors. Herein, flower-like NiCoZn-carbonate hydroxide (NiCoZn-CH) hollow nanospheres are prepared using self-templated NiCoZn-glycerate solid nanospheres through the Kirkendall effect in a solvothermal reaction. Benefiting from a flower-like morphology, NiCoZn-CH not only provides large contact areas on the electrolyte-electrode and an abundant number of active sites but also shortens the ion transportation pathway.

An endolysin gene from Liberibacter asiaticus confers dual resistance to huanglongbing and citrus canker.

The most damaging citrus diseases are Huanglongbing (HLB) and citrus canker, which are caused by Liberibacter asiaticus (Las) and pv. (), respectively. Endolysins from bacteriophages are a possible option for disease resistance in plant breeding.

Towards understanding the cutting temperature in ultrasonic vibration-assisted drilling based on the dynamic contact characteristics between the cutting edge and workpiece.

Compared with conventional drilling (CD), ultrasonic vibration-assisted drilling(UVAD) is experimentally proven a promising method to reduce the cutting temperature. But sometimes cutting temperature also becomes higher in UVAD than in CD. To further make clear the cutting temperature mechanisms in UVAD, this study aims to study the effect of tool's ultrasonic vibration on the cutting heat generation and heat dissipation at a relatively micro level.

Construction of hierarchical MOF-derived CoS microsheet arrays@NiMoS nanoflakes on Ni foam as a high-performance supercapacitor electrode.

The reasonable design of electrode material composition and structure is an effective way to solve the low energy density of supercapacitors. In this paper, hierarchical MOF-derived CoS microsheet arrays@NiMoS nanoflakes on Ni foam (CoS@NiMoS/NF) was prepared by the co-precipitation, electrodeposition and sulfurization process. MOF-derived CoS microsheet arrays on NF are used as ideal backbones to provide fast transport channels, and NiMoS nanoflakes with a network-like distribution on the CoS microsheet arrays can improve the accessible active sites and promote the penetration and transfer of electrolyte ions.

Prevalence and diversity of mycoviruses occurring in Chinese Lentinula edodes germplasm resource.

Incidence and banding patterns of virus-like dsRNA elements in 215 Chinese genetically diverse Lentinula edodes strains collected from wide geographic distribution (or producing areas) were first investigated, and 17 viruses were identified including eight novel viruses. The results revealed a 63.3% incidence of dsRNA elements in the cultivated strains and a 67.

Comparative Study of Graft Healing in 2 Years after "Tension Suspension" Remnant-Preserving and Non-Remnant-Preserving Anatomical Reconstruction for Sherman Type II Anterior Cruciate Ligament Injury.

Purpose: To evaluate the degree of graft healing after "tension suspension" reconstruction of "Sherman II" anterior cruciate ligament injuries versus non-remnant preserving anatomical reconstruction and to compare the clinical outcomes of the two procedures.

Method: The clinical data of 64 patients were retrospectively included. There were 31 cases in the "tension suspension" remnant-preserving reconstruction group and 33 cases in the non-remnant-preserving anatomical reconstruction group.

STRA6 regulates tumor immune microenvironment and is a prognostic marker in BRAF-mutant papillary thyroid carcinoma.

Background: BRAF mutation is one of the most common genetic alterations contributing to the initiation and progression of papillary thyroid carcinoma (PTC). However, the prognostic value of BRAF mutation for PTC is limited. Novel markers are needed to identify BRAF-mutant patients with poor prognosis.

STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.

Background: Metastasis has emerged to be an important cause for poor prognosis of thyroid carcinoma (TC) and its molecular mechanisms are not fully understood. STRA6 is a multifunctional membrane protein widely expressed in embryonic and adult tissues. The function and mechanism of STRA6 in TC remain elusive.

Effects of remnant preservation in anterior cruciate ligament reconstruction: A systematic review and meta-analysis.

Background: Compared with standard anterior cruciate ligament (ACL) reconstruction, it is controversial whether anterior cruciate ligament reconstruction (ACLR) with remnant preservation can lead to better clinical outcomes. We conducted a systematic study and meta-analysis to assess the differences in clinical efficacy between the two.

Method: We searched for clinical randomized controlled studies and cohort studies included in the Cochrane library, PubMed, and Embase from March 2012 to March 2022 in English.

A Study on the Impact of Wushu Sports Health on College Students' Mental Health.

At the current university stage, university students are subjected to a variety of pressures such as role change adaptation pressure, study and life pressure, emotional pressure, economic pressure, employment pressure, and interpersonal pressure, which seriously affect their physical and mental health. Students with poor psychological tolerance may develop psychological disorders and, in serious cases, may even lead to mental illness. The results of the study indicated that 17%-20.

Institutional Trust as a Protective Factor during the COVID-19 Pandemic in China.

Previous research has demonstrated that institutional trust protects subjective well-being during pandemics. However, the potential mediation mechanisms underlying this linkage remain unclear. This study constructs a mediating model to investigate the effect of institutional trust on subjective well-being and the mediating roles of belief in a just world and fear of COVID-19 in the Chinese context.

Macrophage activation by exopolysaccharides from Streptococcus thermophilus fermented milk through TLRs-mediated NF-κB and MAPK pathways.

Lactic acid bacteria-derived exopolysaccharides are known for stimulating immune responses. In our previous study, a novel exopolysaccharide (EPS-3A) from skimmed milk fermented by the strain Streptococcus thermophilus (ZJUIDS-2-01) was extracted and structurally characterized. The present study aimed to investigate the effects of EPS-3A on macrophage activation and identify the underlying mechanism.

Effects of reducing nitrogen application and adding straw on NO emission and soil nitrogen leaching of tomato in greenhouse.

Excessive input of nitrogen(N) fertilizer and improper selection of fertilizer types in the greenhouse vegetable production process will lead to a large amount of N loss. In order to relieve the environmental pollution caused by N loss, a planting experiment was carried out in a solar greenhouse in Shouguang, Shandong, China, to investigate the effects of N-reducing fertilizer and straw application on greenhouse vegetable yield and soil N loss, and to explore the fate of N after fertilizer application using the N isotope tracing technique. The experiment was planted for two seasons from July 2017 to June 2018 with four treatments: control (CK), conventional fertilizer (CN), reduced N topdressing (SN), and reduced N topdressing + straw (SNS).

Curing two predominant viruses occurring in Lentinula edodes by chemotherapy and mycelial fragmentation methods.

Previous research has established that Lentinula edodes mycovirus HKB (LeV-HKB) and L. edodes partitivirus 1(LePV1) are major mycoviruses identified in L.edodes germplasm.

Palladium-catalyzed and alcohol-enabled transformation to synthesize benzocyclic ketones.

Catalytic carbonyl formation ranks as one of the most important synthetic methodologies. Herein, a highly effective palladium-catalyzed and alcohol-promoted transformation of nitriles to synthesize benzocyclic ketones is described. It provides a straightforward access to potentially valuable indanone compounds in high yields in the presence of alcohol.

The complete mitochondrial genome of (Anura: Ranidae) and its phylogenetic analysis.

We reported the complete mitochondrial genome (mitogenome) of broad-folded frog (). This mitogenome is 17,007 bp in size and consists of 13 protein-coding genes, 22 transfer RNAs, two ribosomal RNAs, and one non-coding sequence (D-loop). The total composition was 58.