Publications by authors named "Yijia Shen"
MiR-30d Participates in Vincristine-Induced Neuropathic Pain by Down-Regulating GAD67.
Neurochem Res
February 2022
Article Synopsis
- Vincristine, a common chemotherapy drug, can cause chemotherapy-induced peripheral neuropathy (CIPN), leading to significant pain and economic burden for patients.
- The study found that GAD67, an enzyme critical for GABA synthesis (an inhibitory neurotransmitter), is down-regulated in vincristine-induced neuropathy, while its mRNA levels remain unchanged.
- Researchers identified miR-30d as a microRNA that may be responsible for this down-regulation, and blocking miR-30d improved GAD67 levels and reduced pain symptoms in affected models, providing new insights into the mechanisms behind CIPN and potential pain management strategies.
Article Synopsis
- Paclitaxel, a common chemotherapy drug, can lead to chemotherapy-induced peripheral neuropathy (CIPN), causing pain symptoms like hyperalgesia and allodynia, but the underlying mechanisms are not well understood.
- Research highlights that matrix metalloproteinase-2 (MMP-2) is upregulated in paclitaxel-induced neuropathic pain and that reducing MMP-2 through siRNA can lessen pain sensitivity.
- The study finds that the upregulation of MMP-2 is linked to decreased DNA methylation of its promoter, influenced by the SUMOylation of the DNA methyltransferase DNMT3b, suggesting that targeting these molecular pathways may provide new treatment strategies for
Article Synopsis
- S-metolachlor (S-ME) is a chiral herbicide that, despite only minor effects on wheat's growth and health indicators like chlorophyll and SOD activity, impacts the diversity and structure of its surrounding microbial communities.
- The application of S-ME at 10 mg/kg led to decreased diversity and disrupted the balance of beneficial bacteria essential for the plant's nitrogen fixation, which may ultimately affect wheat growth and yield.
- This study highlights the need to consider the ecological consequences of herbicide use, particularly on phyllosphere microorganisms.
Storing and exhibiting cultural heritages are the basic social functions of museum. Since it is impossible to store or display objects without using containers, cases, or holders, the equipment quality is of great importance. Evaluating the suitability of the equipment should not only learn the mechanical behavior but also focus on the materials because some of them (such as woods) may do harm to the objects due to contaminants released.
View Article and Find Full Text PDFUltraselective Pebax Membranes Enabled by Templated Microphase Separation.
ACS Appl Mater Interfaces
June 2018
Block copolymer materials have been considered as promising candidates to fabricate gas separation membranes. This microphase separation affects the polymer chain packing density and molecular separation efficiency. Here, we demonstrate a method to template microphase separation within a thin composite Pebax membrane, through the controllable self-assembly of one-dimensional halloysite nanotubes (HNTs) within the thin film via the solution-casting technique.
View Article and Find Full Text PDFChronic postsurgical pain (CPSP) often occurs after surgery and has a strong impact on patients' daily lives. However, the underlying mechanism of CPSP remains unknown. Here, we used a skin/muscle incision and retraction (SMIR) model to investigate the role of CX3CL1 in SMIR-induced pain and its underlying mechanism.
View Article and Find Full Text PDFMoS2 Nanosheets Functionalized Composite Mixed Matrix Membrane for Enhanced CO2 Capture via Surface Drop-Coating Method.
ACS Appl Mater Interfaces
September 2016
Molybdenum disulfide (MoS2) is a graphene-like two-dimensional inorganic material, which has been used for the first time as an inorganic nanofiller to prepare a composite mixed matrix membrane to separate CO2 and N2. Polysulfone (PSf) was used as a support substrate and poly(dimethylsiloxane) (PDMS) was used as the gutter layer. The selective layer was prepared by mixing a CO2-philic copolymer Pebax 1657 with MoS2 nanosheets to enhance CO2 permeance.
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