IL-4-induced decrease in both the number and CTLA-4 expression of T impairs suppression of Th2 type inflammation in severe atopic dermatitis.

Background: T plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of T suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive.

Objective: This study aims to investigate the molecular mechanism underlying quantitative and functional changes of T in AD.