Publications by authors named "Yijia Chi"
Article Synopsis
- Genome editing has proven effective in creating isogenic disease models but faces challenges with mature liver cells, prompting a study on improving gene delivery and editing efficiency.
- The research achieved up to 80% editing success in mouse liver cells and explored human-derived hepatocytes for modeling liver cancer.
- Findings revealed specific mutations in genes like PI3KCA that significantly disrupt liver cell functions and contribute to cancer, underscoring their importance in liver tumor development.
High incidence, severe consequences, unclear mechanism, and poor treatment effect happened in Parkinson's disease-related dysphagia. Repetitive transcranial magnetic stimulation is an effective treatment for dysphagia in Parkinson's disease. However, the therapeutic effect and underlying mechanism of repetitive transcranial magnetic stimulation for dysphagia in Parkinson's disease are still unknown.
View Article and Find Full Text PDFAging is an inevitable natural process with time-dependent dysfunction and the occurrence of various diseases, which impose heavy burdens on individuals, families, and society. It has been reported that NLRP3 inflammasome-induced pyroptosis contributes significantly to age-related diseases and aging, while TXNIP is suggested to be involved in regulating pyroptosis mediated by NLRP3. However, the mechanism between TXNIP and NLRP3 inflammasome is still unclear.
View Article and Find Full Text PDFPrecise dissection of DNA-protein interactions is essential for elucidating the recognition basis, dynamics and gene regulation mechanism. However, global profiling of weak and dynamic DNA-protein interactions remains a long-standing challenge. Here, we establish the light-induced lysine (K) enabled crosslinking (LIKE-XL) strategy for spatiotemporal and global profiling of DNA-protein interactions.
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