RNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution.

Bacteria often evolve antibiotic resistance through mutagenesis. However, the processes causing the mutagenesis have not been fully resolved. Here, we find that a broad range of ribosome-targeting antibiotics cause mutations through an underexplored pathway.

Strong Anharmonicity at the Origin of Anomalous Thermal Conductivity in Double Perovskite Cs NaYbCl.

Anomalous thermal transport of Cs NaYbCl double-halide perovskite above room temperature is reported and rationalized. Calculations of phonon dispersion relations and scattering rates up to the fourth order in lattice anharmonicity have been conducted to determine their effective dependence on temperature. These findings show that specific phonon group velocities and lifetimes increase if the temperature is raised above 500 K.

Identification of RNA-binding protein YBX3 as an oncogene in clear cell renal cell carcinoma.

Y box binding protein 3 (YBX3) is an indispensable factor for protein synthesis, cellular growth, and proliferation, and is intricately involved in the progression of diverse tumor types. The objective of the current study was to investigate the role of YBX3 in the prognosis, immune infiltration, and progression of clear cell renal clear cell carcinoma (ccRCC). The expression level of YBX3 in ccRCC tissues was compared using The Cancer Genome Atlas (TCGA) and analyzed using the Wilcoxon rank sum test.

An Efficient Method for Monitoring Birds Based on Object Detection and Multi-Object Tracking Networks.

To protect birds, it is crucial to identify their species and determine their population across different regions. However, currently, bird monitoring methods mainly rely on manual techniques, such as point counts conducted by researchers and ornithologists in the field. This method can sometimes be inefficient, prone to errors, and have limitations, which may not always be conducive to bird conservation efforts.

Spatial transcriptome uncovers rich coordination of metabolism in E. coli K12 biofilm.

Microbial communities often display region-specific properties, which give rise to complex interactions and emergent behaviors that are critical to the homeostasis and stress response of the communities. However, systems-level understanding of these properties still remains elusive. In this study, we established RAINBOW-seq and profiled the transcriptome of Escherichia coli biofilm communities with high spatial resolution and high gene coverage.

The Total Ionizing Dose Effects on Perovskite CsPbBr Semiconductor Detector.

Perovskite CsPbBr semiconductors exhibit unusually high defect tolerance leading to outstanding and unique optoelectronic properties, demonstrating strong potential for γ-radiation and X-ray detection at room temperature. However, the total dose effects of the perovskite CsPbBr must be considered when working in a long-term radiation environment. In this work, the Schottky type of perovskite CsPbBr detector was fabricated.

Profiling of bacterial transcriptome from ultra-low input with MiniBac-seq.

There is a lack of appropriate methods for preparing bacterial RNA-seq library with ultra-low amount of RNA. To address this issue, we developed miniBac-seq, a strand-specific method for high-quality library construction from sub-nanogram of total RNA, which is 100-fold lower than the current benchmark kit and dramatically reduces preparation cost ($28 + $15 × samples). We further demonstrated the high sensitivity of miniBac-seq via detecting more than 500 genes from amount of total RNA equivalent to that of a single bacterial cell.

Perovskite CsPbBr Single Crystal Detector for High Flux X-Ray Photon Counting.

X-ray photon-counting detectors capable of resolving the energies of single X-ray photons are critical in medical imaging, and a high count rate is essential for photon-counting detectors. Here, we report the performance of the perovskite CsPbBr3 single-crystal semiconductor detector for X-ray photon counting. The CsPbBr3 detector noise floor, energy response linearity, energy resolution, count rate, and polarization were evaluated.

TMSB10 Promotes Progression of Clear Cell Renal Cell Carcinoma via JUN Transcription Regulation.

Objective: Thymosin b10 (TMSB10), a member of the thymosin family, is mainly located in cells and participates in the assembly and occurrence of cytoskeleton. We aimed to investigate the regulatory mechanism of TMSB10 in ccRCC.

Methods: In this study, Xiantao Academic Tools were taken to perform the pan-cancer expression and immune infiltration analysis of TMSB10.

miR-142-5p promotes cervical cancer progression by targeting LMX1A through Wnt/β-catenin pathway.

Background: Previous work has shown that miR-142-5p in cervical cancer tissues increased significantly compared with adjacent normal tissues. However, the function and the mechanism of miR-142-5p in cervical cancer have not been reported.

Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to determine the gene expression levels.

Demonstration of Energy-Resolved γ-Ray Detection at Room Temperature by the CsPbCl Perovskite Semiconductor.

The detection of γ-rays at room temperature with high-energy resolution using semiconductors is one of the most challenging applications. The presence of even the smallest amount of defects is sufficient to kill the signal generated from γ-rays which makes the availability of semiconductors detectors a rarity. Lead halide perovskite semiconductors exhibit unusually high defect tolerance leading to outstanding and unique optoelectronic properties and are poised to strongly impact applications in photoelectric conversion/detection.

Triple-Cation and Mixed-Halide Perovskite Single Crystal for High-Performance X-ray Imaging.

Low ionic migration is required for a semiconductor material to realize stable high-performance X-ray detection. In this work, successful controlled incorporation of not only methylammonium (MA ) and cesium (Cs ) cations, but also bromine (Br ) anions into the FAPbI lattice to grow inch-sized stable perovskite single crystal (FAMACs SC) is reported. The smaller cations and anions, comparing to the original FA and I help release lattice stress so that the FAMACs SC shows lower ion migration, enhanced hardness, lower trap density, longer carrier lifetime and diffusion length, higher charge mobility and thermal stability, and better uniformity.

Enhanced Photocurrent of All-Inorganic Two-Dimensional Perovskite CsPbICl via Pressure-Regulated Excitonic Features.

Pressure processing is efficient to regulate the structural and physical properties of two-dimensional (2D) halide perovskites which have been emerging for advanced photovoltaic and light-emitting applications. Increasing numbers of studies have reported pressure-induced and/or enhanced emission properties in the 2D halide perovskites. However, no research has focused on their photoresponse properties under pressure tuning.

Skp2 regulates DNA damage repair and apoptosis via interaction with Ku70.

Purpose: Skp2, an oncoprotein, regulates tumor proliferation, invasion and metastasis. Ku70 is a critical component of the non-homologous end-joining (NHEJ) process. Both Skp2 and Ku70 are positively associated in multiple cancers.

Evaluation of New Monoclonal Anti-MyoD1 (MX049) for the Diagnosis of Rhabdomyosarcoma: Comparison with 5.8A, EP212, Anti-Desmin, Anti-Myogenin, and Fluorescence Hybridization.

Rhabdomyosarcoma (RMS) is a primitive embryonal mesenchymal neoplasm demonstrating skeletal muscle differentiation. Diagnosis of RMS remains difficult due to the diversity of clinical features, pathological forms, and lesion's locations. Immunohistochemistry and Fluorescence in Situ Hybridization are common methods used to aid RMS diagnosis.

Publisher Correction: Nucleation-controlled growth of superior lead-free perovskite CsBiI single-crystals for high-performance X-ray detection.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Nucleation-controlled growth of superior lead-free perovskite CsBiI single-crystals for high-performance X-ray detection.

The organic-inorganic hybrid lead halide perovskites have emerged as a series of star materials for solar cells, lasers and detectors. However, the issues raised by the toxic lead element and marginal stability due to the volatile organic components have severely limited their potential applications. In this work, we develop a nucleation-controlled solution method to grow large size high-quality CsBiI perovskite single crystals (PSCs).

Organic Cation Alloying on Intralayer A and Interlayer A' sites in 2D Hybrid Dion-Jacobson Lead Bromide Perovskites (A')(A)PbBr.

Hybrid layered halide perovskites have achieved impressive performance in optoelectronics. New structural types in the two-dimensional (2D) halide system such as the Dion-Jacobson phases have attracted wide research attention due to the short interlayer distance and unique layer orientation that facilitate better charge-transport and higher stability in optoelectronic devices. Here, we report the first solid solution series incorporating both A and A' cations in the 2D Dion-Jacobson family, with the general formula (A')(A)PbBr ((A' = 3-(aminomethyl)piperidinium (3AMP) and 4-(aminomethyl)piperidinium) (4AMP); A = methylammonium (MA) and formamidinium (FA)).

Thermoplastic Membranes Incorporating Semiconductive Metal-Organic Frameworks: An Advance on Flexible X-ray Detectors.

Semiconductive metal-organic frameworks (MOFs) have emerged in applications such as chemical sensors, electrocatalysts, energy storage materials, and electronic devices. However, examples of semiconductive MOFs within flexible electronics have not been reported. We present flexible X-ray detectors prepared by thermoplastic dispersal of a semiconductive MOF (SCU-13) through a commercially available polymer, poly(vinylidene fluoride).

Publisher Correction: Direct thermal neutron detection by the 2D semiconductor LiInPSe.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Direct thermal neutron detection by the 2D semiconductor LiInPSe.

Highly efficient neutron detectors are critical in many sectors, including national security, medicine, crystallography and astronomy. The main neutron detection technologies currently used involve He-gas-filled proportional counters and light scintillators for thermalized neutrons. Semiconductors could provide the next generation of neutron detectors because their advantages could make them competitive with or superior to existing detectors.

Coherent charge-phonon correlations and exciton dynamics in orthorhombic CHNHPbI measured by ultrafast multi-THz spectroscopy.

We use time-resolved multi-terahertz spectroscopy for the range 4-40 meV to probe coherent and incoherent ultrafast charge carrier and exciton dynamics in the low temperature orthorhombic phase of the hybrid metal halide perovskite CHNHPbI. Time- and energy-resolved terahertz reflectivity maps reveal strongly damped but coherent oscillations in the 2-4 THz reststrahlen band, indicating charge coupling to a distribution of low energy phonon modes centered at 0.9 THz (3.