Synchronized time lens based temporal magnifier assisted by the phase lock loop.

We propose a synchronized time lens based temporal magnifier for the characterization of an ultrafast pulse, which is assisted by the phase lock loop (PLL) to actively lock the repetition rates of the pump laser and signal laser. A feedback control system combining a proportional-integral (PI) circuit and a piezoelectric transducer (PZT) inside the signal laser cavity is used to synchronize the repetition rates between the pump and signal lights. Benefitting from the PLL technique, the temporal position of the signal pulse remains as the numerical aperture of the time lens system, and therefore it has a high short-time stability for pulse measurement.

Highly coherent, flat, and broadband time-stretched swept source based on extra-cavity spectral shaping assisted by a booster semiconductor optical amplifier.

We demonstrate a flat broadband time-stretched swept source based on extra-cavity spectral shaping. By adjusting the polarization-dependent gain profile and driving current of the booster optical amplifier (BOA), extra-cavity spectral shaping is optimized to generate output with a 1-dB bandwidth of ∼100 nm, 3-dB bandwidth of ∼140 nm and output power of ∼21.4 mW.

Fourier Domain Mode Locked Laser and Its Applications.

The sweep rate of conventional short-cavity lasers with an intracavity-swept filter is limited by the buildup time of laser signals from spontaneous emissions. The Fourier domain mode-locked (FDML) laser was proposed to overcome the limitations of buildup time by inserting a long fiber delay in the cavity to store the whole swept signal and has attracted much interest in both theoretical and experimental studies. In this review, the theoretical models to understand the dynamics of the FDML laser and the experimental techniques to realize high speed, wide sweep range, long coherence length, high output power and highly stable swept signals in FDML lasers will be discussed.

Zero-Dimensional MXene-Based Optical Devices for Ultrafast and Ultranarrow Photonics Applications.

In recent years, MXene has become a hotspot because of its good conductivity, strong broadband absorption, and tunable band gap. In this contribution, 0D MXene TiCT quantum dots are synthesized by a liquid exfoliation method and a wideband nonlinear optical response from 800 to 1550 nm is studied, which have a larger nonlinear absorption coefficient of -(11.24 ± 0.

NRAGE suppresses metastasis of melanoma and pancreatic cancer in vitro and in vivo.

We previously reported that human NRAGE could significantly alter the cellular skeleton and inhibit cell-cell adhesion, suggesting that human NRGAE play a potential role in cellular motility. Here, we report overexpression of human NRAGE in PANC-1 and B16-Bl6 cells could significantly suppress the metastasis of these cells in vitro and in vivo. Consistently, PANC-1 with stable silencing of NRAGE by RNA interference, exhibits a more metastatic phenotype than the native cell.

[Construction of recombinant adenovirus vector of hNRAGE gene and its effect on cell cycle of 293 cells].

Aim: To construct the recombinant adenovirus vector of hNRAGE gene and study its effect on the cell cycle of 293 cells.

Methods: hNRAGE gene was amplified by PCR and subcloned into the shuttle vector pAdTrack-CMV to construct a shuttle plasmid pAdTrack-CMV/hNRAGE. After sequencing, it was linearized with Pme I and cotransformed into E.

Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion.

Human NRAGE, a neurotrophin receptor p75 interaction MAGE homologue, confers NGF-dependent apoptosis of neuronal cells by inducing caspase activation through the JNK-c-jun-dependent pathway and arrests cell growth through the p53-dependent pathway. Our findings showed that human NRAGE could significantly alter the cell skeleton and inhibit homotypic cell-cell adhesion in U2OS cells. With further experiments, we revealed that human NRAGE disrupts colocalization of the E-cadherin/beta-catenin complex and translocates beta-catenin from the cell membrane into the cytoplasm and nucleus.