Muscle Fiber-Inspired High-Performance Strain Sensors for Motion Recognition and Control.

The rapid development of wearable technology, flexible electronics, and human-machine interaction has brought about revolutionary changes to the fields of motion analysis and physiological monitoring. Sensors for detecting human motion and physiological signals have become a hot topic of current research. Inspired by the muscle fiber structure, this paper proposed a highly stable strain sensor that was composed of stretchable Spandex fibers (SPF), multiwalled carbon nanotubes (MWCNTs), and silicone rubber (Ecoflex).

Fishing net-inspired PVA-chitosan-CNT hydrogels with high stretchability, sensitivity, and environmentally stability for textile strain sensors.

Soft electronic products are being extensively investigated in diverse applications including sensors and devices, due to their superior softness, responsiveness, and biocompatibility. One-dimensional (1-D) fiber electronic devices are recognized for their lightweight, wearable, and stretchable qualities, thus emerging as critical constituents for seamless integration with the human body and attire, exhibiting great potential in wearable applications. However, wearable conductive hydrogel fibers usually face challenges in combining stretchability and excellent stability, notably in high-temperature environment.

CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.

Investigating the principles of fish fat deposition and conducting related research are current focal points in fish nutrition. This study explores the endocrine regulation of LEAP2 and GHSR1a in zebrafish by constructing mutantmodels andexamining the effects of the endocrine factors LEAP2 and its receptor GHSR1a on zebrafish growth, feeding, and liver fat deposition. Compared to the wild type (WT), the mutation of LEAP2 results in increased feeding and decreased swimming in zebrafish.

Flexible Grid Graphene Electrothermal Films for Real-Time Monitoring Applications.

Flexible electrothermal films are crucial for protecting equipment and systems in cold weather, such as ice blockages in natural gas pipelines and icing on aircraft wings. Therefore, a flexible electric heater is one of the essential devices in industrial operations. One of the main challenges is to develop flexible electrothermal films with low operating voltage, high steady-state temperature, and good mechanical stability.

Validation of the Chinese version of the Rosenberg Self-Esteem Scale: evidence from a three-wave longitudinal study.

Background: The 10-item Rosenberg Self-Esteem Scale (RSES) is a widely used tool for individuals to self-report their self-esteem; however, the factorial structures of translated versions of the RSES vary across different languages. This study aimed to validate the Chinese version of the RSES in the Chinese mainland using a longitudinal design.

Methods: A group of healthcare university students completed the RSES across three waves: baseline, 1-week follow-up, and 15-week follow-up.

DAHNGC: A Graph Convolution Model for Drug-Disease Association Prediction by Using Heterogeneous Network.

In the field of drug development and repositioning, the prediction of drug-disease associations is a critical task. A recently proposed method for predicting drug-disease associations based on graph convolution relies heavily on the features of adjacent nodes within the homogeneous network for characterizing information. However, this method lacks node attribute information from heterogeneous networks, which could hardly provide valuable insights for predicting drug-disease associations.

Assessment of the relative benefits of monotherapy and combination therapy approaches to the treatment of hospital-acquired Stenotrophomonas maltophilia pneumonia: a multicenter, observational, real-world study.

Purpose: Stenotrophomonas maltophilia is a Gram-negative pathogen that most commonly causes hospital-acquired infections that can be extremely challenging to treat, contributing to underrecognized mortality throughout the world. The relative benefits of monotherapy as compared to combination therapy in patients diagnosed with S. maltophilia pneumonia, however, have yet to be established.

Depression and Anxiety Mediate the Association between Sleep Quality and Self-Rated Health in Healthcare Students.

Objectives: This study aimed to investigate factors associated with sleep quality in healthcare students and to determine whether depressive and anxiety symptoms may explain some of the associations between sleep quality and self-rated health.

Study Design: This is a cross-sectional study at wave one.

Methods: A total of 637 healthcare students were recruited via a stratified random sampling method in Hangzhou, China.

The Chinese Version of the Perceived Stress Questionnaire-13: Psychometric Properties and Measurement Invariance for Medical Students.

Purpose: Stress may relate to an increased risk of psychological and physical disorders. Thus, a brief and efficient measurement instrument for researchers to measure stress is essentially needed.

Participants And Methods: To assess measurement properties of the validated Chinese version of the Perceived Stress Questionnaire-13 (PSQ-C-13), we conducted a two-wave longitudinal study from September to December, 2021 with a convenient sample of medical students.

MnO/MnO-CuMnO spinel as an efficient Fenton-like catalyst activating persulfate for the degradation of bisphenol A: Superoxide radicals dominate the reaction.

In this work, a MnO/MnO-CuMnO spinel was fabricated and utilised as a catalyst to activate peroxydisulfate (PDS) leading to degradation of bisphenol A (BPA). The results showed that the system exhibited an excellent turnover frequency (TOF) of 2.7 × 10 s and high stability.

Interfacial Intermixing and Its Impact on the Energy Band Structure in Interband Cascade Infrared Photodetectors.

Multiple-stage interband cascade infrared photodetector (ICIP) is a new class of semiconductor infrared photodetector that exhibits improved device performance in terms of responsivity and detectivity. The design of the device structure and the electronic structure on superlattices and quantum wells assume abrupt interfaces. However, the emergence of possible interface segregation and atom exchange can only be determined experimentally, impacting the device performance.

A psychometric investigation of the Chinese version of the Internal, Personal and Situational Attributions Questionnaire (C-IPSAQ).

The IPSAQ is a self-administered instrument designed to evaluate individuals' attributional style (AS). The purpose of this study is to examine the psychometric properties of the Chinese version of the Internal, Personal and Situational Attributions Questionnaire (C-IPSAQ). We also investigate if patients with depression and patients with delusions exhibit attributional biases.

[Effective connectivity within the default mode network modulated by methylphenidate using dynamic causal modeling on resting-state functional magnetic resonance imaging].

The effective connectivity of default mode network (DMN) and its change after taking methylphenidate (MPH) were investigated in this study based on resting-state functional magnetic resonance imaging. Dynamic causal modeling (DCM) was applied to compare the effective connectivity between the conditions of taking MPH and placebo for 18 healthy male volunteers. Started with the network structural basis provided by a recent literature, endogenous low frequency fluctuation signals (0.

Spontaneous Activity Associated with Delusions of Schizophrenia in the Left Medial Superior Frontal Gyrus: A Resting-State fMRI Study.

Delusions of schizophrenia have been found to be associated with alterations of some brain regions in structure and task-induced activation. However, the relationship between spontaneously occurring symptoms and spontaneous brain activity remains unclear. In the current study, 14 schizophrenic patients with delusions and 14 healthy controls underwent a resting-state functional magnetic resonance imaging (RS-fMRI) scan.

Intrinsic brain activity as a diagnostic biomarker in children with benign epilepsy with centrotemporal spikes.

Benign epilepsy with centrotemporal spikes (BECTS) is often associated with neural circuit dysfunction, particularly during the transient active state characterized by interictal epileptiform discharges (IEDs). Little is known, however, about the functional neural circuit abnormalities in BECTS without IEDs, or if such abnormalities could be used to differentiate BECTS patients without IEDs from healthy controls (HCs) for early diagnosis. To this end, we conducted resting-state functional magnetic resonance imaging (RS-fMRI) and simultaneous Electroencephalogram (EEG) in children with BECTS (n = 43) and age-matched HC (n = 28).

TGF-β isoforms induce EMT independent migration of ovarian cancer cells.

Background: Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cadherin, claudin-3 and claudin-4, commonly decreased in human adenocarcinomas are actually up regulated during ovarian carcinogenesis. In human ovarian cancer TGF-β1 may either suppress or promote tumor progression, but whether other TGF-β isoforms (TGF-β2 and TGF-β3) exert similar effects is not known.

Soluble E-cadherin in systemic lupus erythematosus.

Objective: E-cadherin is a potent adherens junction molecule implicated in tissue morphogenesis, epithelial functioning, and immune regulation. Serum levels of soluble E-cadherin (sE-cadherin), an end product of proteolytic cleavage of E-cadherin, is increased in patients with cancer, infections, and inflammation-related diseases. The aim of our study was to measure serum levels of sE-cadherin in systemic lupus erythematosus (SLE) and to determine associations between serum levels of sE-cadherin and markers of inflammation and organ damage in female patients with SLE.

Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study.

Methylphenidate (MPH) is one of the most commonly used stimulants for the treatment of attention deficit hyperactivity disorder (ADHD). Although several studies have evaluated the effects of MPH on human brain activation during specific cognitive tasks using functional magnetic resonance imaging (fMRI), few studies have focused on spontaneous brain activity. In the current study, we investigated the effect of MPH on the intra-regional synchronization of spontaneous brain activity during the resting state in 18 normal adult males.

Phenotypic plasticity of the ovarian surface epithelium: TGF-beta 1 induction of epithelial to mesenchymal transition (EMT) in vitro.

Ovarian surface epithelium (OSE) is the most conceivable cell origin of epithelial ovarian carcinomas. Unlike many other epithelial tumors, the precancerous lesion acquires expression of epithelial markers, e.g.

Staphylokinase reduces plasmin formation by endogenous plasminogen activators.

Hyperfibrinolysis is a consequence of imbalance between fibrinolytic activators and their inhibitors. Increased levels of circulating plasminogen (Plg) activators such as tissue- or urokinase-type plasminogen activators (tPA or uPA respectively) are the most common causes of hyperfibrinolysis, occasionally causing major hemorrhages. We found that staphylokinase (SAK), a well-known Plg activator of bacterial origin, inhibits Plg activation mediated by endogenous tPA and uPA.

Tight junction formation in epithelial ovarian adenocarcinoma.

Background: Epithelial cells are characterised by their ability to form polarised cell sheets with barriers between two tissue compartments. Epithelial tightness and apical/basolateral orientation are maintained through adherens and tight junctions (TJs). Alterations in junction formation and function could promote tumorigenesis via increased access to growth factors and cytokines.